Evaluation of Risk Factors for Nasopharyngeal Carcinoma in a High-risk Area of India, the Northeastern Region

Lourembam, Deepak Singh; Singh, Asem Robinson; Sharma, Takhenchangbam Dhaneshor; Singh, Th Sudheeranjan; Singh, Thiyam Ramsing; Singh, Lisam Shanjukumar

doi:10.7314/apjcp.2015.16.12.4927

Cited by 27 publications

(17 citation statements)

References 49 publications

(55 reference statements)

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“…In this study, Minangkabau ethnicity in both NPC and controls group found only heterozygote mutants (c1c2), and not related to the incidence of NPC. The same was reported by Lourembam et al who conducted a study in India in areas with a high incidence of NPC also found only heterozygote polymorphisms and also did not get a significant relationship with the incidence of NPC [3]. Hildesheim et al, [2].…”

Section: Discussionsupporting

confidence: 58%

“…Various environmental factors have been reported related to the incidence of Nasopharyngeal Carcinoma (NPC), including consumption of salted fish containing nitrosamines [2], [3]. Study on environmental factors as carcinogens has varied reports, but in endemic areas, nitrosamines from salted fish are a factor that is often associated with the incidence of NPC [3]. but clinical study at Dr. RSUP M. Djamil Padang did not get this association [4].…”

Section: Introductionmentioning

confidence: 99%

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Polymorphisms of CYP2E1 rs2031920 is not Associated with Risk of Nasopharyngeal Carcinoma in Minangkabau Ethnic Group

Rahman¹,

Yerizel²,

Khambri³

et al. 2019

Open Access Maced J Med Sci

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BACKGROUND: Various environmental factors have been suspected to be associated with the risk of developing Nasopharyngeal Carcinoma (NPC). Volatile nitrosamines found in salted fish are thought to be carcinogenic substances for NPC. Nitrosamines are activated by the CYP2E1 enzyme. Several studies investigated the relationship between polymorphism in the CYP2E1 gene and susceptibility to NPC, but the results obtained were inconsistent. AIM: This study was conducted to analyse the association of the CYP2E1 rs2031920 polymorphisms with the incidence of NPC in the Minangkabau ethnic group. METHODS: The subjects of this study were newly diagnosed NPC Minangkabau ethnic patients, while the controls were healthy people. A total of 23 cases of NPC and 23 aged (± 3 years) and sex-matched controls participated in the study. The method used to identify these polymorphisms is PCR sequencing. RESULTS: On recent study, we found CYP2E1 rs2031920 gene polymorphism in both the NPC and control groups, in the NPC group there were 8.7% heterozygote mutants while in the control group there were 26.1% heterozygote mutants, and there were no homozygote mutants in the two groups, and statistically none a significant relationship between CYP2E1 gene polymorphism and the incidence of NPC, with p > 0.05. CONCLUSION: Our study reveals that there is no association of CYP2E1 gene polymorphism (rs2031920) with the incidence of nasopharyngeal carcinoma in the Minangkabau ethnic group.

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Section: Discussionsupporting

confidence: 58%

Section: Introductionmentioning

confidence: 99%

Polymorphisms of CYP2E1 rs2031920 is not Associated with Risk of Nasopharyngeal Carcinoma in Minangkabau Ethnic Group

Rahman¹,

Yerizel²,

Khambri³

et al. 2019

Open Access Maced J Med Sci

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“…In the univariate analysis, we considered the impact of several covariates such as age, gender, urbanization level, insurance fee level, HT, COPD, HL, DM, CS, asthma, EBV infection-related diseases, occupational types and alcoholism, which are associated with tumor development [ 26 – 30 ]. In addition, several studies have reported that active smoking and alcohol consumption are associated with increased NPC risk [ 31 , 32 ]. Nevertheless, the major limitations of the NHIRD is attributed to insufficient information on family history and lifestyle activities such as smoking and alcohol consumption.…”

Section: Discussionmentioning

confidence: 99%

Increased risk of incident nasopharyngeal carcinoma with exposure to air pollution

et al. 2018

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BackgroundNasopharyngeal carcinoma (NPC) is a race-specific malignancy. The nasal cavity is the main entry point for air pollutants or poisonous gases into the human body. However, the risk of NPC in populations exposed to air pollution remains unknown.MethodsWe combined data from the Taiwan Air Quality Monitoring Database (TAQMD) and the Longitudinal Health Insurance Database (LHID) to assess the risk of NPC in a population exposed to air pollution.ResultsMultivariate analysis revealed positive trends for the association between the risk of NPC and exposure to air pollution. After adjusting for potential covariates, the risk of developing NPC increased with the increase in nitrogen dioxide (NO2) and fine particulate matter (PM2.5) exposure concentrations from 1.39 to 2.28 and 2.01 to 1.97, respectively, compared to the risks at the lowest concentration levels.ConclusionsWe identified a significant risk of NPC in a population exposed to air pollution. However, this study had several limitations. Moreover, additional experimental and clinical studies on the associations between environmental factors and NPC risk are warranted.

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“…Genetic alteration, virus infection, and exposure to the environmental factors are the major factors of NPC [2]. Although radiotherapy and chemotherapy are very effective for most of NPC, 30-40 % of NPC still progress into the distant metastasis, and the metastasis is the major cause for the NPC-related death [3].…”

Section: Introductionmentioning

confidence: 99%

Pyruvate dehydrogenase B promoted the growth and migration of the nasopharyngeal carcinoma cells

Tang

Luo

et al. 2016

Tumor Biol.

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Metabolism alteration is one of the hallmarks of cancer cells. Although several studies have demonstrated that glycolysis played important roles in the progression of nasopharyngeal carcinoma (NPC), the functions of specific metabolism-associated genes remain largely unknown. In this study, it was found that Pyruvate dehydrogenase B (PDHB), which catalyzed the conversion of pyruvate to Acetyl-CoA, was downregulated in NPC cells. Forced expression of PDHB in NPC cells inhibited cell growth and migration, while knocking down the expression of PDHB promoted the growth, migration, and tumorigenesis of NPC cells. Mechanism study showed that PDHB inhibited ERK signaling and cell growth driven by RasV12. Collectively, our study demonstrated the suppressive roles of PDHB in the progression of NPC, and restoring the function of PDHB might be a promising strategy for NPC therapy.

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Evaluation of Risk Factors for Nasopharyngeal Carcinoma in a High-risk Area of India, the Northeastern Region

Cited by 27 publications

References 49 publications

Polymorphisms of CYP2E1 rs2031920 is not Associated with Risk of Nasopharyngeal Carcinoma in Minangkabau Ethnic Group

Polymorphisms of CYP2E1 rs2031920 is not Associated with Risk of Nasopharyngeal Carcinoma in Minangkabau Ethnic Group

Increased risk of incident nasopharyngeal carcinoma with exposure to air pollution

Pyruvate dehydrogenase B promoted the growth and migration of the nasopharyngeal carcinoma cells

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