Lack of association of ACE gene I/D polymorphism with obstructive sleep apnea syndrome in Turkish patients

Yakut, Tahsin; Karkucak, Mutlu; Ursavaş, Ahmet; Gulten, T; Burgazlioglu, Basak; Görükmez, Orhan; Karadağ, Mehmet

doi:10.4238/vol9-2gmr755

Cited by 20 publications

(14 citation statements)

References 16 publications

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“…Based on our search strategy, the primary screening produced 21 potentially relevant articles, of which 15 met the inclusion criteria as an attempt to evaluate the association between the ACE I/D polymorphism and occurrence of OSAHS (Xiao et al, 1999;Zhang et al, 2000;Barcelo et al, 2001;Ping et al, 2001;Li et al, 2004a,b;Lin et al, 2004;Zhang et al, 2004;Gu et al, 2006;Li et al, 2006;Bostrom et al, 2007;Benjamin et al, 2008;Koyama et al, 2009;Ogus et al, 2010;Yakut et al, 2010). A total of 1361 OSAHS patients and 1373 controls were analyzed.…”

Section: Search Resultsmentioning

confidence: 99%

“…A total of 1361 OSAHS patients and 1373 controls were analyzed. Of these 15 articles, 9 (Xiao et al, 1999;Zhang et al, 2000;Barcelo et al, 2001;Lin et al, 2004;Bostrom et al, 2007;Benjamin et al, 2008;Koyama et al, 2009;Ogus et al, 2010;Yakut et al, 2010) were published in English and 6 in Chinese (Ping et al, 2001;Li et al, 2004a,b;Zhang et al, 2004;Gu et al, 2006;Li et al, 2006). The detailed selection process is presented in Figure 1.…”

Section: Search Resultsmentioning

confidence: 99%

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Meta-analysis demonstrates lack of association between the ACE gene I/D polymorphism and obstructive sleep apnea-hypopnea syndrome occurrence and severity

Feng¹,

Ri²,

Wan³

et al. 2013

Genet. Mol. Res.

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ABSTRACT. Published data on a possible association between the angiotensin-converting enzyme (ACE) gene I/D polymorphism and obstructive sleep apnea-hypopnea syndrome (OSAHS) occurrence and its severity risk are inconclusive. We performed a meta-analysis of case-control studies published in English or Chinese. Thirteen studies, totaling 1361 cases and 1373 controls, were investigated for association of the ACE I/D polymorphism with OSAHS. We also made a study of ACE I/D with OSAHS severity risk, including 879 mild/moderate OSAHS patients and 357 severe OSAHS patients. A random-effects model was used, irrespective of between-study heterogeneity. Study quality was assessed in duplicate. Overall, the ACE I/D polymorphism was not significantly associated with an increase in OSAHS risk [odds ratio (OR) = 1.21; 95% confidence interval (95%CI) = 0.88-1.65; P = 0.24]. In subgroup analysis by ethnicity, comparison of alleles I with D demonstrated a 58% (nonsignificantly) increased risk for OSAHS in Chinese (OR = 1.58; 95%CI = 0.92-2.70; P = 0.09). We also found that there was no significant association between ACE I/D and OSAHS severity risk. No publication biases were observed. This meta-analysis suggests that there is no significantly increased risk for OSAHS occurrence or severity associated with the ACE I/D polymorphism.

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Section: Search Resultsmentioning

confidence: 99%

Section: Search Resultsmentioning

confidence: 99%

Meta-analysis demonstrates lack of association between the ACE gene I/D polymorphism and obstructive sleep apnea-hypopnea syndrome occurrence and severity

Feng¹,

Ri²,

Wan³

et al. 2013

Genet. Mol. Res.

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“…Evidence has shown that genetic determinants of upper-airway muscle activity, craniofacial structure, obesity, fat distribution, and respiratory control may interact and cause OSA (Casale et al, 2009). Most genetic association studies have focused on the TNF-α, ACE I/D, and APOE genes (Cosentino et al, 2008;Popko et al, 2008;Bhushan et al, 2009;Yakut et al, 2010). Bhushan et al (2009) reported that the frequency of the TNF-α (-308A) allele and serum TNF-α levels were significantly higher in obese Asian Indians with OSA.…”

Section: Discussionmentioning

confidence: 99%

Relationship between zinc finger protein 36 (ZFP36) gene polymorphisms and obstructive sleep apnea

Zhang

Abulikemu

et al. 2015

Genet. Mol. Res.

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ABSTRACT. Recent data have indicated that inflammation may have an important correlation with obstructive sleep apnea (OSA). Studies have indicated a relationship between OSA and TNF-α gene polymorphisms. Zinc finger protein 36 (ZFP36) regulates TNF-α mRNAs. However, ZFP36 gene polymorphisms have not been investigated in OSA. Therefore, we conducted the present case-control study to assess whether variances in ZFP36 gene polymorphisms account for differences in TNF-α levels in patients with moderate-tosevere OSA. This case-control study aims to investigate the relationship between genetic variations in the ZFP36 gene and moderate-to-severe OSA. Three common single nucleotide polymorphisms of the ZFP36 gene (rs251864, rs3746083, and rs17879933) were evaluated in a group of patients with moderate-to-severe OSA (N = 408) and in a control Y. Zhang et al. 6734©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (2): 6733-6743 (2015) group (N = 394) by using TaqMan polymerase chain reaction analysis. The moderate-to-severe OSA group and the control group exhibited significant differences in the distributions of rs251864 and rs17879933 genotypes and alleles (P < 0.05). TNF-α levels were significantly different not only among the three rs251864 genotypes but also between the II genotype and the DD + ID genotypes of rs17879933. However, no significant differences in sleep apnea parameters in the three ZFP36 gene polymorphisms were observed. Logistic regression analyses demonstrated that TNF-α and the three ZFP36 gene polymorphisms were not independently associated with OSA. ZFP36 might be involved in TNF-α regulation. However, ZFP36 gene variants were not independent risk factors for moderate-to-severe OSA.

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“…Besides, IRS gene polymorphisms were investigated in glucose metabolism disorders [27,28]. In a study, Bayazit et al [28] suggested that the polymorphism of the IRS-1 gene at codon 972, especially Gly/Arg variant or the presence of the allele for Arg appears to be associated with occurrence of OSAS in male patients, whereas this polymorphism is not related to severity of OSAS.…”

Section: Medicine Science 2013;2(4):830-41 Irs Gene Polymorphism In Omentioning

confidence: 99%

Lack of Association of Insulin Receptor Substrate Gene Polymorphisms with Obstructive Sleep Apnea Syndrome

Saraç¹,

Berdeli²,

Başoğlu³

et al. 2013

Med-Science

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Sleep apnea syndrome is associated with increased prevalence of diabetes and has recently shown to be associated with insulin resistance. The aim of the present study was to investigate the relationships between insulin resistance, insulin receptor substrate-1 (IRS-1), insulin receptor substrate-2 (IRS-2) gene polymorphisms and obstructive sleep apnea syndrome (OSAS). The study population consisted of 56 consecutive patients with OSAS and 26 subjects without OSAS were enrolled in the study. Genotyping of IRS-1 and IRS-2 were amplified by polymerase chain reaction (PCR). Insulin resistance was estimated using the homeostasis model assessment (HOMA

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Lack of association of ACE gene I/D polymorphism with obstructive sleep apnea syndrome in Turkish patients

Cited by 20 publications

References 16 publications

Meta-analysis demonstrates lack of association between the ACE gene I/D polymorphism and obstructive sleep apnea-hypopnea syndrome occurrence and severity

Meta-analysis demonstrates lack of association between the ACE gene I/D polymorphism and obstructive sleep apnea-hypopnea syndrome occurrence and severity

Relationship between zinc finger protein 36 (ZFP36) gene polymorphisms and obstructive sleep apnea

Lack of Association of Insulin Receptor Substrate Gene Polymorphisms with Obstructive Sleep Apnea Syndrome

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