Lack of association between urotensin-II (UTS2) gene polymorphisms (Thr21Met and Ser89Asn) and migraine

Abstract

Migraine is a common neurovascular brain disorder with heterogeneous clinical presentation, including recurrent headache attacks. The pathophysiology of migraine is complex, and a number of genomic regions have been associated with the development of migraine. In this study, we analyzed the allele and genotype frequencies of the urotensin-II gene (UTS2) polymorphisms, Thr21Met and Ser89Asn, among Turkish patients with migraine. A total of 146 patients with migraine (14 with aura [MA group] and 132 without aura [MO group]) were genotyped for Thr21Met and Ser89Asn polymorphisms and compared with 154 age- and sex-matched healthy controls. The UTS2 gene polymorphisms were analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). No significant differences were observed in allele and genotype frequencies for Thr21Met and Ser89Asn polymorphisms between the patients with migraine and control group. Similarly, we did not observe significant differences in allele and genotype frequencies between MA and MO and control group. Moreover, the haplotype analysis showed no association between UTS2 gene haplotypes (MN, MS, TN, and TS) and migraine. In summary, Thr21Met and Ser89Asn polymorphisms of the UTS2 gene are not risk factors for migraine in our sample of Turkish migraine patients.

Genetic overlap between temporomandibular disorders and primary headaches: A systematic review

“…From the included studies, a brief description of the study design and sample is provided, followed by identifying the genes involved in the pathophysiology of either PHD ( Table 3 ) [29] , [30] , [31] , [32] , [33] , [34] , [35] , [36] , [37] , [38] , [39] , [40] , [41] , [42] , [43] , [44] , [45] , [46] , [47] , [48] , [49] , [50] , [51] , [52] , [53] , [54] , [55] , [56] , [57] , [58] , [59] , [60] , [61] , [62] , [63] , [64] , [65] , [66] , [67] , [68] , [69] , [70] , [71] , [72] , [73] , [74] , [75] , [76] , [77] , [78] , [79] , [80] or TMD ( Table 4 ) [81] , [82] , [83] , [84] , [85] , [86] , [87] , [88] , [89] , [90] , [91] , [92] , [93] , [94] ,…”

“… - GABRQ rs3810651 could play a role on the modification of the age of onset of migraine. GABRE GABRQ Ozan, B., et al (2017) [44] Case-control study MO (132); MA (14); & controls (154) UTS2 (Thr21Met, Ser89Asn) - no significant differences were observed for Thr21Met and Ser89Asn SNPs between the diseased patients and control group and between MA and MO and control group; - no association between UTS2 gene haplotypes and migraine. -Thr21Met and Ser89Asn SNPs of the UTS2 gene are not risk factors for migraine in this sample of Turkish migraine patients.…”

Impact of Fibromyalgia Syndrome on the Severity of Migraine Without Aura

“…Migraine leads to loss of financial resources and reduces work capacity and productivity and also indi-viduals' quality of life (8). Despite many efforts, the exact cause of migraine is still unknown, and there is no definitive cure for that; thus, management of this disease is necessary (9,10). According to the literature, many patients with migraine will have other problems that aggravate their tendency to headaches, including anxiety, depression, and other pain syndromes such as fibromyalgia syndrome (FMS).…”

Analysis of the prognosis related genes in HER2+ breast cancer based on weighted gene co-expression network analysis

“…Among its related pathways are RET signaling and signaling by GPCR. [ 4 ] Gene Ontology (GO) annotations related to this gene include signaling receptor binding and hormone activity. [ 5 ] Chen et al [ 6 ] constructed an immunogenetic model of colon cancer using genes such as UTS2 better to predict patient survival at 5 years.…”