Lack of association between the CDH1 polymorphism and gastric cancer susceptibility: a meta-analysis

Abstract

E-Cadherin (CDH1) plays a key role in cell adhesion, which is vital to the normal development and maintenance of cells. Down regulation of CDH1, may lead to dysfunction of the cell-cell adhesion system, resulting in increased susceptibility to tumor development and subsequent tumor cell invasion and metastasis. The CDH1 C-160A polymorphism could decrease its transcription efficiency and may increase susceptibility to cancer development, but its relevance to gastric cancer is generally disputed. Consequently, we performed a meta-analysis of published case-control studies, including 4218 gastric cancer cases and 5461 controls. Overall, no significant association was observed between the CDH1 C-160A polymorphism and risk of gastric cancer in all genetic models. In the stratified analysis by total sample size, a significant association was observed in the small sample size subgroup (total sample size < 300), but the results should be interpreted with caution. In conclusion, this meta-analysis failed to confirm the association between the CDH1 C-160A polymorphism and risk of gastric cancer. Large-scale and well-designed studies are needed to confirm our findings.

Association between the CDH1-472delA and -160C>A polymorphisms and diffuse and intestinal gastric cancer in a Mexican population

“…This has also been observed in several other populations, as reported in previous meta-analyses (Chen et al, 2011, Cui et al, 2011Wang et al, 2011;Li et al, 2012;Deng et al, 2014;Jiang et al, 2015) including several studies and a large number of samples. However, the mutated genotype A/A of the -160C>A SNP was associated with increased DGC risk in a Mexican population (N = 39 diffuse GC) (20.5%, OR = 6.5, 95%CI = 2.1-19.6) (Medina-Franco et al, 2007).…”

“…The haplotypes at these polymorphic sites have been analyzed previously in two Chinese studies (Zhang et al, 2008a;Jiang et al, 2015). We performed an analysis with these data (exclusively for the -472delA and -160C>A polymorphic sites), which revealed no significant differences between our results and those reported in the two Chinese populations, suggesting that the -472delA and -160C>A polymorphisms are not related to risk or protection for gastric cancer in both Chinese and Mexican populations.…”

Association of Interleukin-10 -1082 a/G (Rs1800896) Polymorphism With Susceptibility to Gastric Cancer: Meta-Analysis of 6,101 Cases and 8,557 Controls

“…In the recent years, many exciting discoveries regarding the genomics of gastric cancer have been made, but it remains a major health problem as a result of the population growth, ageing, high mortality and poor prognosis for this disease (1)(2)(3) . The incidence of gastric cancer varies considerably according to age, gender, socioeconomic conditions and ethnicity, and despite some of the highest risk populations are in Asian countries such as Japan, Korea and China, other Asian countries present relatively low rates (4)(5)(6) .…”

“…To date, the etiology of gastric cancer is still not fully understood (7) . It is well known that environmental factors such as dietary habits, Helicobacter pylori (H. pylori) infection, tobacco smoking, and alcohol consumption are more important than genetics in the development and progression of gastric cancer (1)(2)(3)8) . However, only 1%-5% of individuals with the bacteria actually develop gastric cancer and the pathogenesis is dependent on bacterial strain virulence, host genetic susceptibility and environmental factors (9) .…”

Genetic Variations and Gastric Cancer

“…Recently, a considerable number of studies have been conducted to investigate the associations between the CDH1 C-160A polymorphism and susceptibility for GC [16,17,18,19]. However, a recent meta-analysis failed to confirm the association between the CDH1 C-160A polymorphism and risk of GC [20]. …”