Association between the CDH1-472delA and -160C>A polymorphisms and diffuse and intestinal gastric cancer in a Mexican population

Abstract

ABSTRACT. Gastric cancer (GC), the third leading cause of cancerrelated deaths in Mexico and worldwide, can be classified into diffuse (DGC) or intestinal (IGC) types based on its histological characteristics. DGC is characterized by reduced expression of the cell adhesion protein E-cadherin, which is encoded by CDH1. The -472delA (rs5030625) and -160C>A (rs16260) polymorphisms in CDH1 induce a decrease in gene transcription; in fact, these mutated alleles have been associated with GC in some populations, with conflicting results. The aim of this study was to determine the association between the CDH1 -472delA and -160C>A polymorphisms and DGC and IGC in Mexican patients. The study was conducted in 24, 23, 48, and 93 individuals with DGC and IGC, without GC (control), and belonging to the general Mexican population (GMP), respectively. The genotypes were obtained by polymerase chain reaction -restriction fragment length polymorphism and the obtained data analyzed using Arlequin 3.1. The frequencies of the mutated allele (A) of -472delA were 0.326, 0.318, 0.284, and 0.296 in the DGC, IGC, control, and GMP groups, respectively, and those of the -160C>A polymorphism were 0.174, 0.318, 0.313, and 0.280, respectively. The genotype and allele frequencies of the two polymorphisms did not differ significantly (P > 0.05) among DGC, IGC, and control subjects. Therefore, we concluded that the CDH1 -472delA and -160C>A polymorphisms are not associated with DGC or IGC in patients from western Mexico.

CDH1 somatic alterations in Mexican patients with diffuse and mixed sporadic gastric cancer

“…An important aspect to consider is that, with the exception of variant -285C > A (or -160C > A) [21], no other variants have been described for the Mexican population. It would be important to investigate the frequencies of the variants described in this population (Additional file 4).…”

Genetic polymorphisms in CDH1 and Exo1 genes elevate the prostate cancer risk in Bangladeshi population

“…In our study, the normal C and variant A allele frequencies in CDH1 gene were found to be 69.0% and 31.0% in cases. On the other hand, frequency of variant A allele was found to be 16.6% in Han Chinese population for pancreatic cancer, 45 15.9% and 20.0% in Chinese population for gastric and esophageal cancer, 44 17.0% in Mexico for gastric cancer, 42 and 34.2% in India for breast cancer. 67 For Exo1 (K589E) gene, variant A allele frequency in our study group was found to be 35.0%, whereas in other studies carried out in China and Taiwan, the frequencies were 24.3%, 21.0%, 22.8%, and 25.0% for gastric, 36 breast, 37 lung, 38 and cervical cancer, 75 respectively.…”

Characteristics and antioxidant properties of cold pressed high oleic and linoleic oils from Mexican safflower varieties

“…High consumption of SFA and MUFA has been associated with increased risk, whereas PUFA intake reduced (70-80%) that risk of gastric cancer in Mexico (López-Carrillo et al, 1999;Sampieri and Mora, 2014). The main sources of PUFA in the Mexican diet are sunflower and safflower oils; therefore increased use of our high linoleic safflower oil (75-86% PUFA, 10-23 PUFA/SFA ratio) can be effective in greatly reducing the risk of gastric cancer, the third leading cause of cancer related deaths in Mexico (Bustos-Carpinteyro et al, 2016). Furthermore, the antioxidant components of safflower oil, particularly the phenolics may also play an important etiological role in reducing the risk of chronic diseases and attenuating inflammation, the major risk factor for metabolic diseases.…”