Lack of Association Between the Cholesteryl Ester Transfer Protein Gene—TaqIB Polymorphism and Coronary Restenosis Following Percutaneous Transluminal Coronary Angioplasty and Stenting: A Pilot Study

Kaestner, Sabine; Patsouras, Nikolaos; Spathas, D. H.; Flordellis, Christodoulos S.; Manolis, Antonis S.

doi:10.1177/0003319709348297

Cited by 7 publications

(9 citation statements)

References 35 publications

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“…The allele and genotypic frequencies observed in the present study are comparable with previous findings [32][33][34][35]. Our results are consistent with findings of other studies which have revealed that CETP-(rs708272) polymorphism was not associated with CAD [35][36][37]. In contrast to our results, positive association was reported by Bhanushali and Das [38] Rahimi et al, [39], Kaman et al, [40] and Iwanicka et al, [41].…”

Section: Discussionsupporting

confidence: 92%

Association of ESR1 (rs2234693 and rs9340799), CETP (rs708272), MTHFR (rs1801133 and rs2274976) and MS (rs185087) polymorphisms with Coronary Artery Disease (CAD)

Raina

Sharma

Panjaliya

et al. 2020

BMC Cardiovasc Disord

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Background: Coronary artery disease (CAD) is a complex disease resulting from the cumulative and interactive effects of large number of genes along with environmental exposure. Therefore, the present study was envisaged as an effort to study the association of candidate genes ESR1 (rs2234693 and rs9340799), CETP (rs708272), MTHFR (rs1801133 and rs2274976) and MS (rs185087) polymorphisms with the risk of CAD, targeting the populations of Jammu (JandK). Method: A total of 400 confirmed CAD patients and 400 healthy controls were enrolled for the present study. Genotyping was done by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results: ESR1 gene (rs9340799) polymorphism was found to be associated with CAD in all the genetic models. The haplotype analysis of ESR1 (rs2234693 and rs9340799) gene revealed that C-G haplotype was conferring approximately 5-fold risk and T-A haplotype was adding 1.4-fold risk towards the disease. 'T' allele of MTHFR rs1801133 SNP was observed to be responsible for development of CAD in our study population (p < 0.0001). In case of MTHFR (rs1801133 and rs2274976) gene, the haplotype T-G was observed to confer 4.7-fold risk towards CAD whereas haplotype C-G provided nearly a 1.7 fold protection towards development of CAD. For MS gene, rs185087 was also found to be associated with CAD in a co-dominant (p = 0.003 and p = 0.03), dominant (p = 0.001) and allelic models (p = 0.001). The gene-gene interaction revealed strong epistasis between single nucleotide polymorphisms (SNPs), ESR1 rs9340799 and MTHFR rs2274976. Furthermore, the dendrogram for gene-environment dataset indicated moderately synergistic interaction between CETP rs708272 and physical inactivity. Conclusion: In the study under reference, a significant association of ESR1-XbaI (rs9340799), MTHFR C677T (rs1801133) and MS A2756G (rs185087) gene polymorphisms with the susceptibility of CAD in the population of Jammu region (JandK) has been observed.

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Section: Discussionsupporting

confidence: 92%

Association of ESR1 (rs2234693 and rs9340799), CETP (rs708272), MTHFR (rs1801133 and rs2274976) and MS (rs185087) polymorphisms with Coronary Artery Disease (CAD)

Raina

Sharma

Panjaliya

et al. 2020

BMC Cardiovasc Disord

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“…All the eligible studies were published between 1991 and 2012.There were 20 studies performed in Asian subjects [ 11 , 38 , 47 , 51 , 57 , 58 , 60 , 63 , 65 , 66 ], 26 in Caucasian subjects [ 17 , 20 - 22 , 36 , 37 , 40 - 46 , 49 , 50 , 52 - 56 , 59 , 61 , 62 , 64 , 67 ] and one mixed- population study [ 48 ]. In consideration of the study design, 6 studies were prospective [ 20 , 40 , 43 , 45 , 49 ] and the remaining 41 studies were retrospective [ 11 , 17 , 21 , 22 , 36 - 38 , 41 , 42 , 44 , 46 - 48 , 50 - 67 ]. In addition,11 of the 47 studies were P-B [ 20 - 22 , 36 , 37 , 40 , 43 , 46 , 49 , 54 ] and the remaining studies were H-B [ 11 , 17 , 38 , 39 , 41 , 42 , 44 , 45 , 47 , 48 , 50 -…”

Section: Resultsmentioning

confidence: 99%

“…In consideration of the study design, 6 studies were prospective [ 20 , 40 , 43 , 45 , 49 ] and the remaining 41 studies were retrospective [ 11 , 17 , 21 , 22 , 36 - 38 , 41 , 42 , 44 , 46 - 48 , 50 - 67 ]. In addition,11 of the 47 studies were P-B [ 20 - 22 , 36 , 37 , 40 , 43 , 46 , 49 , 54 ] and the remaining studies were H-B [ 11 , 17 , 38 , 39 , 41 , 42 , 44 , 45 , 47 , 48 , 50 - 53 , 55 - 66 ]. CAD was regarded as the main outcome in most of the studies [ 11 , 17 , 21 , 22 , 36 - 40 , 42 , 44 , 45 , 47 , 49 - 51 , 53 , 55 - 61 , 64 - 66 ], except 8 studies analyzed MI [ 20 , 43 , 46 , 48 , 52 , 54 , 62 , 63 ] and 2 studies analyzed ACS [ …”

Section: Resultsmentioning

confidence: 99%

Association of cholesteryl ester transfer protein (CETP) gene polymorphism, high density lipoprotein cholesterol and risk of coronary artery disease: a meta-analysis using a Mendelian randomization approach

Lou

Qiu

et al. 2014

BMC Med Genet

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BackgroundRecent randomized controlled trials have challenged the concept that increased high density lipoprotein cholesterol (HDL-C) levels are associated with coronary artery disease (CAD) risk reduction. The causal role of HDL-C in the development of atherosclerosis remains unclear. To increase precision and to minimize residual confounding, we exploited the cholesteryl ester transfer protein (CETP)-TaqIB polymorphism as an instrument based on Mendelian randomization.MethodsThe Mendelian randomization analysis was performed by two steps. First, we conducted a meta-analysis of 47 studies, including 23,928 cases and 27,068 controls, to quantify the relationship between the TaqIB polymorphism and the CAD risk. Next, the association between the TaqIB polymorphism and HDL-C was assessed among 5,929 Caucasians. We further employed Mendelian randomization to evaluate the causal effect of HDL-C on CAD based on the findings from the meta-analysis.ResultsThe overall comparison of the B2 allele with the B1 allele yielded a significant risk reduction of CAD (P < 0.0001; OR = 0.88; 95% CI: 0.84–0.92) with substantial between-study heterogeneity (I2 = 55.2%; Pheterogeneity <0.0001). The result was not materially changed after excluding the Hardy-Weinberg Equilibrium (HWE)-violation studies. Compared with B1B1 homozygotes, Caucasian carriers of the B2 allele had a 0.25 mmol/L increase in HDL-C level (95% CI: 0.20–0.31; P <0.0001; I2 = 0; Pheterogeneity =0.87). However, a 1 standard deviation (SD) elevation in HDL-C levels due to the TaqIB polymorphism, was marginal associated with CAD risk (OR =0.79; 95% CI: 0.54–1.03; P =0.08).ConclusionsTaken together, our results lend support to the concept that increased HDL-C cannot be translated into a reduction in CAD risk.Electronic supplementary materialThe online version of this article (doi:10.1186/s12881-014-0118-1) contains supplementary material, which is available to authorized users.

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“…Previous studies indicate that certain genetic polymorphisms are recognized to be associated with the risk of coronary restenosis. [14][15][16][17][18][19] Among these genes, the ACE gene polymorphisms were considered as a risk factor of coronary restenosis in several published papers [20][21][22][23][24][25][26][27][28][29][30][31][32][33][34] ; however, the results of these studies were inconsistent. Rebrova et al 34 found that ACE genetic polymorphism is associated with coronary restenosis risk.…”

Section: Association Of Ace Insertion or Deletion Polymorphisms With mentioning

confidence: 99%

Association of ACE insertion or deletion polymorphisms with the risk of coronary restenosis after percutaneous coronary intervention: A meta-analysis

Miao

Gong

2015

J Renin Angiotensin Aldosterone Syst

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Objective: Previous case-control studies on the relationship between the angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphisms and coronary restenosis did not reach the same conclusion. In the present study, we aimed to further evaluate the relationship between the ACE gene I/D polymorphisms and coronary restenosis, after percutaneous coronary intervention (PCI). Methods: By searching PubMed, EMBase, the Chinese Biomedical Literature Database and Wanfang database, we selected 16 case-control studies related to ACE gene I/D polymorphism and coronary restenosis after PCI. To test for heterogeneity in each study, we utilized the Q-test and I2 test. To merge the odds ratio (OR) and 95% CI, we utilized the random effects model during the analyses. Results: The present study included 4693 subjects: 1241 patients with coronary restenosis and 3452 without coronary restenosis. By meta-analysis, we found there was significant association of ACE gene I/D polymorphism with coronary restenosis (D allele versus I allele: OR = 1.92; 95% CI (1.40–2.43); p < 0.001). A subgroup analysis, by stratification according to ethnicity, also showed that this association was found not only in the Caucasian population ((D allele versus I allele: OR = 1.94; 95% CI (1.38–2.80); p < 0.001)), but also in the Asian population ((D allele versus I allele: OR = 1.83; 95% CI (1.05–3.20); p = 0.03)). After stratification according to age, we found that the D allele carriers have a higher risk for development of coronary restenosis in subjects < 60 years old (OR = 2.13; 95% CI: 1.40–3.24; p = 0.0004); while in the subjects ⩾ 60 years old, the association was present with bordering significance (OR = 1.48; 95%CI: 0.98–2.25; p = 0.06). Conclusions: The present study suggested that the ACE gene I/D polymorphism was associated with coronary restenosis, regardless of age and ethnicity.

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Lack of Association Between the Cholesteryl Ester Transfer Protein Gene—TaqIB Polymorphism and Coronary Restenosis Following Percutaneous Transluminal Coronary Angioplasty and Stenting: A Pilot Study

Cited by 7 publications

References 35 publications

Association of ESR1 (rs2234693 and rs9340799), CETP (rs708272), MTHFR (rs1801133 and rs2274976) and MS (rs185087) polymorphisms with Coronary Artery Disease (CAD)

Association of ESR1 (rs2234693 and rs9340799), CETP (rs708272), MTHFR (rs1801133 and rs2274976) and MS (rs185087) polymorphisms with Coronary Artery Disease (CAD)

Association of cholesteryl ester transfer protein (CETP) gene polymorphism, high density lipoprotein cholesterol and risk of coronary artery disease: a meta-analysis using a Mendelian randomization approach

Association of ACE insertion or deletion polymorphisms with the risk of coronary restenosis after percutaneous coronary intervention: A meta-analysis

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