Lack of Association between Periodic Limb Movements during Sleep and Neuroimaging Signatures of Cerebral Small Vessel Disease in Stroke-Free Community-Dwelling Older Adults. The Atahualpa Project

Periodic Limb Movements Syndrome in Patients With Cerebral Small Vessel Disease: Protocol for a Prospective Observational Study

“…WMH increase and cognitive decline, which are the key features of cSVD progression, will be assessed. In comparison with the researches conducted by Kang et al (51) and Del Brutto et al (105), our study has a longitudinal observational design, which seems to be more appropriate for the purpose of risk factors identification than a cross-sectional design. These researchers came to the opposite conclusions in their studies that seem to support the utility of further investigation of the problem.…”

Sleep and perivascular spaces in the middle‐aged and elderly population

“…Our population‐based findings seem inconsistent with previous clinical studies in patients with sleep or neurological disorders, that predominantly report an association of poor sleep across different characteristics with higher PVS load (Berezuk et al, 2015; Opel et al, 2019; Si et al, 2020; Song et al, 2017; Wang et al, 2020). Noteworthy, two studies from one population‐based cohort also mostly reported null findings (Del Brutto et al, 2019, 2020). A potential difference across study types suggest that an association between sleep and PVS may only exist within the context of clinical disorders.…”

“…Some sleep characteristics, such as a lower sleep efficiency (Berezuk et al, 2015; Del Brutto, Mera, Del Brutto, & Castillo, 2019) have been associated with higher PVS load, but other studies have reported no associations for those same, and other sleep characteristics (Aribisala et al, 2019; Berezuk et al, 2015; Burnett, Witte, & Ahlskog, 2014; Del Brutto, Mera, Del Brutto, & Castillo, 2020; Opel et al, 2019; Ramirez et al, 2021; Si et al, 2020; Song et al, 2017; Wang et al, 2020; Zhang et al, 2021). Studies using population‐based samples, to see if findings generalise outside of a clinical context, are scarce (Aribisala et al, 2019; Del Brutto et al, 2019, 2020). Also, associations may differ due to the use of subjective versus objective measurements (Del Brutto et al, 2019), as subjective measurements also reflect the experience of sleep and are therefore more influenced by other factors than physiological sleep alone.…”

“…We assessed the relation of objectively measured sleep through both actigraphy and polysomnography (PSG) with MRI‐assessed PVS load in four brain regions in a population‐based cohort. We hypothesised that indicators of poor sleep would be related to higher PVS load (Aribisala et al, 2019; Berezuk et al, 2015; Burnett et al, 2014; Del Brutto et al, 2019, 2020; Opel et al, 2019; Si et al, 2020; Song et al, 2017; Zhang et al, 2021).…”

“…Several, mostly clinical, studies have determined whether poor sleep determines higher PVS load on MRI and found mixed results. Some sleep characteristics, such as a lower sleep efficiency (Berezuk et al, 2015;Del Brutto, Mera, Del Brutto, & Castillo, 2019) have been associated with higher PVS load, but other studies have reported no associations for those same, and other sleep characteristics (Aribisala et al, 2019;Berezuk et al, 2015;Burnett, Witte, & Ahlskog, 2014;Del Brutto, Mera, Del Brutto, & Castillo, 2020;Opel et al, 2019;Ramirez et al, 2021;Si et al, 2020;Song et al, 2017;Wang et al, 2020;Zhang et al, 2021).…”