Sleep and Perivascular Spaces

Dredla, Brynn K.; Del Brutto, Oscar H.; Castillo, Pablo R.

doi:10.1007/s11910-023-01293-z

Cited by 3 publications

(2 citation statements)

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“…BG-PVS enlargement reflects diminished waste clearance and is the result of a pathological cascade involving perivascular inflammation and impaired vasoreactivity. 28 These considerations are in line with the results of a recent study showing that increased volume of the choroid plexus may impair glymphatic clearance and envisage WMH progression. 8 However, the above-mentioned study has potential drawbacks as it was conducted in a small number of individuals and some of them had previous neurological disorders demanding a lumbar puncture.…”

Section: Discussionsupporting

confidence: 81%

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Choroid plexus calcifications are not associated with putative markers of glymphatic dysfunction: A population study in middle-aged and older adults

Castillo,

Patel,

Mera

et al. 2024

Neuroradiol J

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Background and Purpose Recent studies have suggested an association between dysfunction of the choroid plexus and the glymphatic system. However, information is inconclusive. Following a population-based study design, we aimed to assess the association between choroid plexus calcifications (CPCs)—as a surrogate of choroid plexus dysfunction—and severity and progression of putative markers of glymphatic dysfunction, including white matter hyperintensities (WMH) of presumed vascular origin and abnormally enlarged basal ganglia perivascular spaces (BG-PVS). Methods This study recruited community-dwellers aged ≥40 years living in neighboring Ecuadorian villages. Participants who had baseline head CTs and brain MRIs were included in cross-sectional analyses and those who additional had follow-up MRIs (after a mean of 6.4 ± 1.5 years) were included in longitudinal analyses. Logistic and Poisson regression models, adjusted for demographics and cardiovascular risk factors, were fitted to assess associations between CPCs and WMH and enlarged BG-PVS severity and progression. Results A total of 590 individuals were included in the cross-sectional component of the study, and 215 in the longitudinal component. At baseline, 25% of participants had moderate-to-severe WMH and 27% had abnormally enlarged BG-PVS. At follow-up, 36% and 20% of participants had WMH and enlarged BG-PVS progression, respectively. Logistic regression models showed no significant differences between CPCs volumes stratified in quartiles and severity of WMH and enlarged BG-PVS. Poisson regression models showed no association between the exposure and WMH and enlarged BG-PVS progression. Baseline age remained significant in these models. Conclusions Choroid plexus calcifications are not associated with putative markers of glymphatic system dysfunction.

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Section: Discussionsupporting

confidence: 81%

“…BG-PVS enlargement reflects diminished waste clearance and is the result of a pathological cascade involving perivascular inflammation and impaired vasoreactivity. 28…”

Section: Discussionmentioning

confidence: 99%