Lack of association between <i>ACE</i> insertion/deletion polymorphism and lung cancer: A meta-analysis

Cheng, Zhenshun; Ma, Ran; Tan, Wanlong; Zhang, Li; Tan, Qian

doi:10.1177/1470320314544163

Cited by 12 publications

(8 citation statements)

References 18 publications

(26 reference statements)

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“…18 A current study by Cheng did not report any association between the ACE gene I/D polymorphism and lung cancer in either genotype or allele distribution. 19 This is the first study demonstrating possible effects of ACE I/D gene polymorphism on the risk of CLL in the Sudanese population, this finding is consistent with that reported by AKALIN I et al [8] which concluded that their study is the first study indicating possible effects of ACE I/D gene polymorphism of the local bone marrow RAS components on leukemic hematopoiesis.…”

Section: Discussionsupporting

confidence: 90%

Angiotensin Converting Enzyme Insertion/Deletion Gene Polymorphisms in Sudanese Patients with Chronic Lymphocytic Leukaemia

Ibrahim¹

2019

UHOD

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The aim of this study was to investigate the association between Angiotensin converting enzyme (ACE) insertion/deletion (I/D) polymorphism and the risk of chronic lymphocytic leukaemia (CLL) in Sudanese patients. We present a case control study that includes 40 Sudanese patients with CLL. Among them, 31 (62%) were male and 19 (38%) were female. In addition, 40 subjects who were healthy, were included as a control group. Among them, 19 (47.5%) male and 21 (52.5%) female). Molecular analysis showed that the most frequent genotype in CLL patients was I/I, followed by genotypes D/I and D/D. In the control group, D/D was the most frequent genotype, followed by I/D. The I/I genotype was absent. Our data suggested that a significant association was found between ACE I/D polymorphism and CLL among Sudanese patients.

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Section: Discussionsupporting

confidence: 90%

Angiotensin Converting Enzyme Insertion/Deletion Gene Polymorphisms in Sudanese Patients with Chronic Lymphocytic Leukaemia

Ibrahim¹

2019

UHOD

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“…However, most studies regarding the I/D polymorphism of the ACE gene that increases the levels of its converting enzyme do not present the expected results. Despite the data indicating that homozygotes for the D allele are approximately twice as likely to develop lung cancer (136), meta-analyses and case-control studies in populations from Europe and Asia have failed to find a significant association between the polymorphic genotypes and lung carcinogenesis (136)(137)(138)(139)(140)(141). However, a subgroup analysis in a case-control study in 2012 revealed a significantly high risk for squamous non-small cell lung carcinoma (NSCLC) in Croatians who carry the DD genotypic variant (137).…”

Section: Lung Cancer and Ace I/d Polymorphismmentioning

confidence: 99%

The Impact ofACEandACE2Gene Polymorphisms in Pulmonary Diseases Including COVID-19

Gintoni

Αδαμοπούλου

Yapijakis

2021

In Vivo

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Chronic and acute respiratory diseases pose a major problem for public health worldwide due to the high morbidity and mortality rates, while treatment options remain mostly symptomatic. The renin-angiotensin system (RAS) plays an important role in lung tissue, regulating pulmonary circulation and blood pressure, but also contributing to normal pulmonary function and development. Angiotensin-converting enzyme (ACE) and its homologous angiotensin-converting enzyme 2 (ACE2) are considered to be amongst the main RAS regulators and are highly expressed in the pulmonary vascular endothelium. This review discusses the impact of ACE and ACE2 functional gene polymorphisms on seven major pulmonary diseases, in terms of predisposition, course, and outcome, revealing their potential utility as both genetic markers and biomarkers. The discussed conditions include chronic obstructive pulmonary disease (COPD), pulmonary hypertension (PH), asthma, acute lung injury (ALI), acute respiratory distress syndrome (ARDS), lung cancer and pulmonary sarcoidosis (PS), as well as SARS-CoV-2 viral infection and COVID-19 disease.Chronic respiratory diseases (CRDs) have been among the leading causes of morbidity and mortality around the globe for the last two decades (1-3). Their constantly increasing rates of occurrence may vary both between the genders, but also between different regions and socio-economic backgrounds (4). Nevertheless, the common denominator includes the deterioration of patients' quality of life that can often lead to several years of disability. The main CRDs are chronic obstructive pulmonary disease (COPD), pulmonary hypertension (PH), asthma and lung cancer, with COPD alone being the third leading cause of death worldwide, as reported in 2010 (1,5,6).On the other hand, acute lung diseases with an infectional etiology, pose a significant threat not only to lung health but also to human life (7). A recent great example is the 2019 outbreak of the novel coronavirus strain SARS-CoV-2 in China, causing the extremely infectious disease COVID-19, that led to a global pandemic and to millions of deaths, mainly due to severe respiratory complications (8, 9). So far, therapeutic approaches are mainly symptomatic, while knowledge on the exact pathogenetic mechanisms for complex lung-diseases remains limited. Consequently, prevention is predominantly based on general lifestyle guidelines, whereas the establishment of a priori personalized preventive measures, according to an individual's genetic predisposition, is still in its infancy (1, 5). Nevertheless, there are important known genetic markers that may be utilized for their predictive value.The renin-angiotensin system (RAS), in addition to its great importance for the overall homeostasis of the body, through the regulation of blood pressure and electrolyte balance, has a strong tissue-specific expression in the respiratory tract and functions both autonomously and 13 This article is freely accessible online.

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“…5,6 The association of ACE gene I/D polymorphism with cancer susceptibility has been widely evaluated; however the results are not often reproducible. 7,8 For instance, a previous study in a European population documented that ACE gene II genotype was significantly associated with a reduced risk of having gastric cancer relative to the DD genotype homozygotes, 9 and contrastingly carriers of II genotype were at an increased risk for gastric cancer in a Japanese population. 10 However, other studies have identified a nearly neutral contribution of ACE gene I/D polymorphism to gastric cancer risk.…”

Section: Introductionmentioning

confidence: 99%

The relationship between angiotensin-converting enzyme gene insertion/deletion polymorphism and digestive cancer risk: Insights from a meta-analysis

Yang

Cai

et al. 2015

J Renin Angiotensin Aldosterone Syst

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Background and objective: The gene encoding angiotensin-converting enzyme (ACE) has been implicated in the development of several malignancies. We aimed to meta-analyze the association of ACE gene insertion/deletion (I/D) polymorphism with digestive cancer risk and seek possible sources of between-study heterogeneity. Methods: Two authors independently assessed eligibility of each retrieved publication and gathered relevant data. Risk estimates were expressed as odds ratio (OR) and 95% confidence interval (CI). Results: Sixteen publications were qualified for analysis, involving 2903 digestive cancer cases and 10,833 controls. Overall analyses failed to show any significance for digestive cancer risk. There was moderate heterogeneity and lower publication bias for overall comparisons. In subgroup analyses, ACE gene II genotype was associated with a 15% reduced risk (OR=0.85, 95% CI: 0.57–1.27, p=0.434) for gastric cancer, but a 16% increased risk (OR=1.16, 95% CI: 0.89–1.52, p=0.273) for colorectal cancer. By source of controls, the I allele appeared to be a protective factor against digestive cancer in population-based studies (OR=0.87, 95% CI: 0.75–1.00, p=0.055) but a risk-conferring factor in hospital-based studies (OR=1.17, 95% CI: 1.01–1.35, p=0.033). Conclusion: Our findings suggested that ACE gene I allele might be a protective factor against gastric cancer, necessitating further confirmation in large, population-based studies.

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Lack of association between ACE insertion/deletion polymorphism and lung cancer: A meta-analysis

Cited by 12 publications

References 18 publications

Angiotensin Converting Enzyme Insertion/Deletion Gene Polymorphisms in Sudanese Patients with Chronic Lymphocytic Leukaemia

Angiotensin Converting Enzyme Insertion/Deletion Gene Polymorphisms in Sudanese Patients with Chronic Lymphocytic Leukaemia

The Impact ofACEandACE2Gene Polymorphisms in Pulmonary Diseases Including COVID-19

The relationship between angiotensin-converting enzyme gene insertion/deletion polymorphism and digestive cancer risk: Insights from a meta-analysis

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