Angiotensin Converting Enzyme Insertion/Deletion Gene Polymorphisms in Sudanese Patients with Chronic Lymphocytic Leukaemia

Ibrahim, Ibrahim Khidir

doi:10.4999/uhod.193355

Cited by 3 publications

(1 citation statement)

References 17 publications

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“…ACE2 receptor is expressed on the surface of hematopoietic stem cells within the context of local bone marrow RAS, representing a target for SARS-CoV-2 attack on bone marrow hematopoiesis [31, 32]. Previously, interrelationships between hematopoietic RAS, lymphoid malignancies, and ACE polymorphisms had been demonstrated [33, 34]. The latest hematological research disclosed the importance of ACE-hematopoietic stem cell dynamics during the progression of COVID-19 [2, 31, 35].…”

Section: Discussionmentioning

confidence: 99%

Human Ace D/I Polymorphism Could Affect the Clinicobiological Course of COVID-19

Aladağ

Taş

Ozdemir

et al. 2021

J Renin Angiotensin Aldosterone Syst

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Introduction. The coronavirus disease 2019 (COVID-19), that is caused by severe acute respiratory syndrome corona virus 2 (SARS-CoV-2), has spread rapidly worldwide since December 2019. The SARS-CoV-2 virus has a great affinity for the angiotensin-converting enzyme-2 (ACE-2) receptor, which is an essential element of the renin-angiotensin system (RAS). This study is aimed at assessing the impact of the angiotensin-converting enzyme (ACE) gene insertion (I)/deletion (D) polymorphisms, on the susceptibility and clinical outcomes of the COVID-19 immunoinflammatory syndrome. Patients and Methods. A total of 112 patients diagnosed with COVID-19 between 1 and 15 May 2020 were enrolled in the study. ACE gene allele frequencies were compared to the previously reported Turkish population comprised of 300 people. Results. The most common genotype in the patients and control group was DI with 53% and II with 42%, respectively. The difference in the presence of the D allele between the patient and control groups was statistically significant (67% vs. 42%, respectively, p < 0.0001 ). Severe pneumonia was observed more in patients with DI allele (31%) than DD (8%) and II (0%) ( p = 0.021 ). The mortality rate, time to defervescence, and the hospitalization duration were not different between the genotype groups. Conclusion. Genotype DI of ACE I/D polymorphism is associated with the infectious rate particularly severe pneumonia in this study conducted in the Turkish population. Therefore, ACE D/I polymorphism could affect the clinical course of COVID-19.

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Section: Discussionmentioning

confidence: 99%

Human Ace D/I Polymorphism Could Affect the Clinicobiological Course of COVID-19

Aladağ

Taş

Ozdemir

et al. 2021

J Renin Angiotensin Aldosterone Syst

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Angiotensin-converting Enzyme Insertion/Deletion Polymorphism (rs4646994) and Susceptibility to Acute Lymphoblastic Leukemia: A Case–control Study

Abdulaziz

Ali²

2022

Open Access Maced J Med Sci

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BACKGROUND: Angiotensin-converting enzyme (ACE) stimulates the proliferation of bone marrow hematopoietic progenitors and thought to be involved in pathological neoplastic hematopoiesis and leukemogenesis. AIM: This study aimed to investigate the association between ACE gene I/D polymorphism and the risk of acute lymphoblastic leukemia (ALL). MATERIALS AND METHODS: A total of 96 subjects were recruited for the study, 48 patients with ALL, and 48 apparently healthy volunteers as a control group. Genomic DNA was extracted from peripheral leukocytes and ACE I/D polymorphism was analysed using allele-specific polymerase chain reaction. RESULTS: In both study groups, the ACE D/D polymorphic genotype was the most frequent (52.1% and 54.2%, respectively), followed by the ID genotype (47.9% and 45.8% respectively), while the II genotype was completely absent in both study groups. The distribution of the polymorphic genotypes among the study groups was not significantly different (p = 0. 0.398). The frequency of the D allele was 0.76 in the patients and 0.77 in the control group, while the frequency of I allele was 0.24 in the patients and 0.23 in the control group. No deviation from Hardy–Weinberg equilibrium was observed (χ2 = 4.24, df = 1, p = 0.12). CONCLUSION: ACE I/D polymorphism is not associated with susceptibility to ALL among the Sudanese population.

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Genetic Insights Into Leukemia Susceptibility in the Arab Population: A Scoping Review

Algarni

2024

Cureus

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As per the Global Cancer Observatory, the WHO Eastern Mediterranean region (which includes the Arabic countries) ranks highest for age-standardized mortality rate at 4 per 100,000, thus indicating a probable role of genetic associations. Identifying the genes associated with leukemia in the Arab population is crucial for effective preventive and treatment strategies. This scoping review aimed to determine the nature and extent of research available on the genes associated with the major types of leukemia among the Arab population. As per the scoping review guidelines, a comprehensive search was conducted in PUBMED and Google Scholar for articles published before 01/10/2023 and focused on leukemia-related genes among the Arab population. In total 119 studies, focusing on genes associated with leukemia met the inclusion criteria. On reviewing these studies, 27 genes were found to be associated with ALL, 33 genes with AML, seven genes with CLL, and 14 genes with CML. The majority of these genes were associated with an increased risk for the disease. Notably, the 119 studies covered only nine out of the 22 Arab countries, with 56 studies carried out in Egypt, exhibiting an imbalance in the regional distribution of the research landscape. Thus, indicating the inadequacy of research on leukemia genetics in the Arab region in comparison to the Western studies. This finding highlights the need for extensive research in the Middle Eastern region to gain geographically heterogeneous genetic information about the Arab population. In conclusion, this scoping study highlights the genes associated with the major types of leukemia among the Arab population and also indicates the need for comprehensive and regionally balanced research on leukemia genetics in Middle Eastern countries. Addressing this gap is essential to provide robust genetic data that can be used for targeted interventions to improve leukemia outcomes in the Middle East. Increased research efforts in all Middle Eastern countries will contribute to a greater understanding of genetic predisposition and help develop effective prevention strategies and treatments tailored to this population.

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Angiotensin Converting Enzyme Insertion/Deletion Gene Polymorphisms in Sudanese Patients with Chronic Lymphocytic Leukaemia

Cited by 3 publications

References 17 publications

Human Ace D/I Polymorphism Could Affect the Clinicobiological Course of COVID-19

Human Ace D/I Polymorphism Could Affect the Clinicobiological Course of COVID-19

Angiotensin-converting Enzyme Insertion/Deletion Polymorphism (rs4646994) and Susceptibility to Acute Lymphoblastic Leukemia: A Case–control Study

Genetic Insights Into Leukemia Susceptibility in the Arab Population: A Scoping Review

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