Lack of association between HPV and sperm parameters as a risk factor in infertile men admitted to infertility clinic

Tafvizi, Farzaneh; Fard, Zahra Tahmasebi

doi:10.29252/jmj.13.3.37

Cited by 4 publications

(6 citation statements)

References 11 publications

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“…This difference was statistically significant. It should be noted that, in Tafvizi’s ( 16 ) study, the frequency of HPV was zero in the case and control groups ( Figure 2 ). A funnel plot is used to investigate publication bias to estimate the odds ratio of male infertility due to exposure to CMV, HCMV, and HPV.…”

Section: Resultsmentioning

confidence: 80%

Evaluation of the Presence of Bacterial and Viral Agents in the Semen of Infertile Men: A Systematic and Meta-Analysis Review Study

et al. 2022

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ObjectivesInfections in the male genitourinary system with bacterial and viral agents may play a significant role in male infertility. These agents usually infect the urethra, seminal vesicles, prostate, epididymis, vas deferens, and testes retrograde through the reproductive system. A meta-analysis review study was performed to evaluate the presence of bacterial and viral agents in the semen of infertile men and its correlation with infertility.MethodsRelevant cross-sectional and/or case-control studies were found by an online review of national and international databases (Web of Science, PubMed, Scopus, Science Direct, and Google scholar), and suitable studies were selected. A checklist determined the qualities of all studies. Heterogeneity assay among the primary studies was evaluated by Cochran’s Q test and I2 index (significance level 50%). A statistical analysis was conducted using the Comprehensive Stata ver. 14 package (StataCorp, College Station, TX, United States).ResultsSeventy-two studies were included in this meta-analysis. Publication bias was compared with Egger’s test, and the impact of each research on overall estimate was evaluated by sensitivity analysis. In 56 studies, the rate of bacterial infections in the semen of infertile men was 12% [95% confidence interval (CI): 10–13]. Also, in 26 case-control studies, the association of infertility in men with bacterial infections was evaluated. The results show that the odds ratio of infertility in men exposed to bacterial infections is 3.31 times higher than that in non-infected men (95% CI: 2.60–4.23). Besides, in 9 studies that examined the prevalence of human papillomavirus (HPV), herpes simplex virus 1 (HSV1), herpes simplex virus 2 (HSV2), and herpes simplex virus 1-2 (HSV1-2) in infertile men, the frequency of these viruses was 15% (95% CI: 9–21). In 6 case-control studies, the association between human cytomegalovirus (HCMV), Cytomegalovirus (CMV), and HPV and male infertility was evaluated. The chance of male infertility due to exposure to these viruses was 2.24 times higher than those without exposure to these viruses (CI 95%: 1.9–4.52). The results show that the chance of infertility in men exposed to bacteria was significantly higher than that in the uninfected population.ConclusionThis meta-analysis showed that viral and bacterial infections are a risk factor and could impair male fertility potential. Moreover, our study supports the hypothesis that bacterial and viral infections of the genital tract correlate positively with impairment of sperm quality in the male population.

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Section: Resultsmentioning

confidence: 80%

Evaluation of the Presence of Bacterial and Viral Agents in the Semen of Infertile Men: A Systematic and Meta-Analysis Review Study

et al. 2022

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“…In our study, 64% of the semen samples from infertile men had problems in parameters including sperm count, motility, morphology, and pH, which is almost identical to the rates in previous studies in Iran (11,12). Nevertheless, some researchers believe that infertility is possible even in asymptomatic men, often due to infections that decrease semen quality by affecting sperm motility and morphology (13,14).…”

Section: Discussionmentioning

confidence: 99%

In-vitro Antimicrobial Effect of Silybum marianum Extract on Bacterial Isolates from the Semen of Infertile Men in Iran

2020

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Background: Genital tract infection is one of the main causes of male infertility. The increasing frequency of drug resistance and side effects of antibiotics have urged researchers to seek alternative sources of antimicrobial agents, such as medicinal herbs, for the treatment of antibiotic-resistant infections. Objectives: The present study aimed to determine the frequency of potentially pathogenic microorganisms in the semen of infertile men and investigate the antimicrobial activity of Silybum marianum extract against the isolates. Methods: Semen samples were collected from 96 infertile men who referred to the Pasteur Laboratory in Gorgan, Iran. Semen samples were first analyzed according to the World Health Organization guidelines and then underwent microbiological tests to identify pathogens. Antimicrobial susceptibility to S. marianum extract was evaluated using the disk diffusion (Kirby-Bauer) method. Moreover, the active components of the extract were identified by the gas chromatography-mass spectrometry technique. Results: In the semen analysis, 64% of the samples had problems in the parameters of sperm count, motility, and morphology. In addition, the bacterial contamination was observed in 36% of semen samples. The most and the least common isolates were Staphylococcus aureus (45%) and Klebsiella pneumoniae (11%) and Staphylococcus epidermidis (11%), respectively. In Gram-positive isolates, S. aureus was mostly resistant to azithromycin (57%). In Gram-negative isolates, Escherichia coli was mostly resistant to gentamicin (37%). The inhibitory activity of S. marianum flower extract was significantly higher than that of S. marianum leaf extract (P < 0.01). Silybin (2.64%) and silychristin (3.07%) were the most abundant constituents of S. marianum flower extract. Conclusions: Bacterial infections play an important role in male infertility and S. marianum extract after purification can be potentially used for the treatment of antibiotic-resistant genital tract infections.

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“…These ndings may be due to alterations in semen composition, such as pH, viscosity of the semen, leukocyte count, presence of anti-sperm antibodies, or increased DNA fragmentation [22,23]. However, several studies identi ed no association between altered sperm parameters and HPV infection in infertile men [24,25]. In this regard, few studies have been conducted in Iran, which have shown inconsistent results [25,26].…”

Section: Introductionmentioning

confidence: 99%

“…However, several studies identi ed no association between altered sperm parameters and HPV infection in infertile men [24,25]. In this regard, few studies have been conducted in Iran, which have shown inconsistent results [25,26]. Since the prevalence of HPV infection and its different genotypes depends on the geographical region [27], it appears necessary to investigate the possible relationship between this infection and semen quality in the population from different geographical areas such as Iran.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Human Papillomavirus in Iranian infertile men and its association with semen quality

Niakan

Faghihloo

Mofarahe

et al. 2023

Preprint

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Background: The present article aims to elucidate the prevalence of Human Papillomavirus (HPV) infection and possible association between HPV infection and semen parameters in infertile Iranian men. Materials and methods: This cross-sectional study included semen samples from 140 male partners in couples seeking fertility evaluation. Standard semen analysis was performed. In addition, sperm DNA fragmentation index (DFI), sperm chromatin maturation, presence of anti-sperm antibodies, leukocyte count, and Fructose and Zinc concentration were also assessed. Nested PCR and INNO-LiPA assay were used to identify HPV-DNA sequences in semen samples and determine HPV genotype, respectively. Results: HPV DNA was detected in 18/140 (12.85%) of the semen samples (10% high-risk (HR), 2.14% low-risk (LR) genotypes, and one sample was excluded). Our findings revealed that HPV18 was the most prevalent type (8.57%). According to our result, the presence of HPV DNA in the semen samples was associated with a higher white blood cell count (leukocytospermia) (P=0.02). We also observed that LR HPV-positive semen samples were associated with higher DFI values (P = 0.01). Conclusion: This study showed that the presence of HPV in semen samples was associated with leukocytospermia. We also observed that the presence of low-risk genotypes in semen samples was associated with higher sperm DFI values. These results point to the importance of careful screening for the presence of HPV in semen samples from infertile men. It should also be noted that more studies are required to have a more comprehensive view of the relationship between HPV infection and semen quality.

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Lack of association between HPV and sperm parameters as a risk factor in infertile men admitted to infertility clinic

Cited by 4 publications

References 11 publications

Evaluation of the Presence of Bacterial and Viral Agents in the Semen of Infertile Men: A Systematic and Meta-Analysis Review Study

Evaluation of the Presence of Bacterial and Viral Agents in the Semen of Infertile Men: A Systematic and Meta-Analysis Review Study

In-vitro Antimicrobial Effect of Silybum marianum Extract on Bacterial Isolates from the Semen of Infertile Men in Iran

Prevalence of Human Papillomavirus in Iranian infertile men and its association with semen quality

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