Lack of association between genetic polymorphisms within KCNQ1 locus and type 2 diabetes in Tunisian Arabs

Turki, Amira; Mtiraoui, Nabil; Al-Busaidi, Amna S; Khirallah, Moncef; Mahjoub, Touhami; Almawi, Wassim Y.

doi:10.1016/j.diabres.2012.10.006

Cited by 20 publications

(12 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This finding is consistent with data from Arab populations and middle-aged Han populations in East China Turki et al, 2012), but contradicts the conclusions drawn by several other studies (Yasuda et al, 2008;Hu et al, 2009;Liu et al, 2009;Qi et al, 2009;Tan et al, 2009;Rees et al, 2011;Saif-Ali et al, 2011).…”

Section: Discussioncontrasting

confidence: 39%

Relationship between the polymorphisms in KCNQ1 and type 2 diabetes in Chinese Kazakh population

Cui¹,

Xy²,

Ly³

et al. 2016

Genet. Mol. Res.

View full text Add to dashboard Cite

ABSTRACT. Recently genome-wide association studies on East Asian populations reported an association between diabetes and several single nucleotide polymorphisms (SNPs) in a 40-kb linkage disequilibrium block in intron 15 of KCNQ1. However, the association between KCNQ1 variants and type 2 diabetes mellitus (T2DM) in Chinese Kazakh populations is unknown. We investigated the relationship between rs2237892 and rs2237895 SNPs in KCNQ1 and susceptibility to and clinical characteristics of T2DM in 100 Chinese Kazakh T2DM subjects and 100 healthy subjects. SNPs were genotyped by polymerase chain reaction-restriction fragment length polymorphism and the main anthropometric and biochemical parameters of individuals were assessed in the genotype groups (rs2237892: CC, CT, or TT, and rs2237895: AA, AC, or CC). Genotype distribution and allele frequencies of these two SNPs were not significantly different between T2DM and control groups (P > 0.05). The frequencies of CT and TT genotypes and T allele for the rs2237892 SNP in females with T2DM were significantly higher than that in the control group (genotype: P = 0.016, allele: P = 0.004). However, there were no significant differences among individuals with different genotypes with respect to the rs2237895 SNP (P > 0.05). The main anthropometric and biochemical parameters did not correlate with the rs2237892 or rs2237895 SNPs in the T2DM group (P > 0.05). Thus, the T allele-containing genotypes of the rs2237892 SNP in KCNQ1 may increase the susceptibility to T2DM in female Chinese Kazakh individuals, whereas the rs2237895 SNP may not be associated with T2DM in the Chinese Kazakh population.

show abstract

Section: Discussioncontrasting

confidence: 39%

Relationship between the polymorphisms in KCNQ1 and type 2 diabetes in Chinese Kazakh population

Cui¹,

Xy²,

Ly³

et al. 2016

Genet. Mol. Res.

View full text Add to dashboard Cite

show abstract

“…Our findings are in line with a study by Bazzi et al (2014) that also reported a lack of association between KCNQ1 SNP rs2237892 in the Saudi population with T2D. Furthermore, a study conducted on North African Arabs also revealed a lack of association between SNPs in KCNQ1 and T2D ( Turki et al , 2012 ). Our data contradict other studies which have suggested that these SNPs are strongly associated with T2D ( Lee et al , 2008 ; Unoki et al , 2008 ; Yasuda et al , 2008 ; Jonsson et al , 2009 ; Hu et al , 2009 ; Liu et al ., 2009 ; Mussig et al , 2009 ; Been et al , 2011 ; Qian et al , 2015 ).…”

Section: Discussionsupporting

confidence: 92%

Type 2 diabetes associated variants of KCNQ1 strongly confer the risk of cardiovascular disease among the Saudi Arabian population

et al. 2017

View full text Add to dashboard Cite

Genome-wide association studies have identified several loci associated with an increased risk for cardiovascular disease (CVD) and type 2 diabetes (T2D). Polymorphisms within the KCNQ1 (potassium voltage-gated channel, KQT-like subfamily, member 1) gene are consistently associated with T2D in a number of populations. The current study was undertaken to evaluate the association of 3 polymorphisms of KCNQ1 (rs2237892, rs151290 and rs2237895) with T2D and/or CVD. Patients diagnosed with either T2D (320 patients), CVD (250 patients) or both (60 patients) and 516 healthy controls were genotyped by TaqMan assay run on a real time PCR thermocycler. A statistically significant association was found for SNPs rs151290 (OR = 1.76; 95%CI = 1.02-3.05; p = 0.0435) and rs2237895 (OR = 2.49; 95%CI = 1.72-3.61; p < 0.0001) with CVD. SNP rs151290 (OR = 7.43; 95%CI = 1.00-55.22; p = 0.0499) showed a strong association in patients with both T2D and CVD. None of the SNPs showed any significant association with T2D. Haploview analysis showed that the ACC (rs151290, rs2237892 and rs2237895) haplotype is the most significant risk allele combination for CVD, while CCA is the most significant risk haplotype for co-morbidity with T2D. KCNQ1 polymorphism at SNPs rs151290 and rs2237895 is strongly associated with CVD in this population, but presented no association with T2D.

show abstract

“…To our knowledge, this is the first study to evaluate the relationship between KCNQ1 gene variation and the risk of developing T2DM in the population of northwestern China. Malays, Asian Indians) and Malaysian Chinese the subjects, Spanish Renastur cohort or Tunisians [22,[26][27][28]. Similarly, rs2283228 variants have also been shown to be associated with T2DM in Europe (Denmark), Singapore (Chinese, Malays, and Asian Indians), Japan, and South Korea, but not associated with T2DM in Singapore (China) and Tunisia Arabs [8,9,22,26].…”

Section: Discussionmentioning

confidence: 96%

Relationship between KCNQ1 gene polymorphisms and type 2 diabetes in the population of northwestern China and a meta-Analysis

Xu¹,

Zhang²,

Song³

et al. 2019

Preprint

View full text Add to dashboard Cite

Aims The purpose of this study was to explore the correlation between Potassium Voltage-Gated Channel Subfamily Q Member 1 (KCNQ1) gene polymorphisms and the risk of type 2 diabetes mellitus (T2DM) and its clinical indicators in the population of northwestern China, and conducted a meta-analysis on two polymorphic loci that have been studied frequently and controversial. Methods A case control study was conducted, involving 508 patients and 503 healthy individuals in the population of northwest China, and evaluated the associations using the χ2 test, Fisher's exact test, T test, and genetic model analyses. Results We discovered that rs2237895 rs2283228, rs163184, and rs163177 were associated with susceptibility to T2DM. Rs231362 rs231356, rs8181588 were related to the risk of T2DM after stratification. The results of meta-analysis also confirmed that rs2237895 and rs2283228 were strongly correlated with T2DM risk, especially in the East Asian population. Conclusions This study provides evidence for the correlation between KCNQ1 gene polymorphisms and T2DM in the population of northwestern China.

show abstract

Lack of association between genetic polymorphisms within KCNQ1 locus and type 2 diabetes in Tunisian Arabs

Cited by 20 publications

References 33 publications

Relationship between the polymorphisms in KCNQ1 and type 2 diabetes in Chinese Kazakh population

Relationship between the polymorphisms in KCNQ1 and type 2 diabetes in Chinese Kazakh population

Type 2 diabetes associated variants of KCNQ1 strongly confer the risk of cardiovascular disease among the Saudi Arabian population

Relationship between KCNQ1 gene polymorphisms and type 2 diabetes in the population of northwestern China and a meta-Analysis

Contact Info

Product

Resources

About