Relationship between KCNQ1 gene polymorphisms and type 2 diabetes in the population of northwestern China and a meta-Analysis

Abstract

Aims The purpose of this study was to explore the correlation between Potassium Voltage-Gated Channel Subfamily Q Member 1 (KCNQ1) gene polymorphisms and the risk of type 2 diabetes mellitus (T2DM) and its clinical indicators in the population of northwestern China, and conducted a meta-analysis on two polymorphic loci that have been studied frequently and controversial. Methods A case control study was conducted, involving 508 patients and 503 healthy individuals in the population of northwest China, and evaluated the associations using the χ2 test, Fisher's exact test, T test, and genetic model analyses. Results We discovered that rs2237895 rs2283228, rs163184, and rs163177 were associated with susceptibility to T2DM. Rs231362 rs231356, rs8181588 were related to the risk of T2DM after stratification. The results of meta-analysis also confirmed that rs2237895 and rs2283228 were strongly correlated with T2DM risk, especially in the East Asian population. Conclusions This study provides evidence for the correlation between KCNQ1 gene polymorphisms and T2DM in the population of northwestern China.