Lack of Association between Endothelin-1 Gene Variants and Myocardial Infarction

Palacín, María; Rodrı́guez-Pascual, Fernando; Reguero, Julián R.; Rodríguez, Isabel; Avanzas, Pablo; Lozano, Íñigo; Morı́s, César; Álvarez, Victoria; Cannata‐Andía, Jorge B.; Lamas, Santiago; García-Castro, Mónica; Coto, Eliécer

doi:10.5551/jat.no1149

Cited by 13 publications

(10 citation statements)

References 42 publications

(34 reference statements)

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“…but inconsistent with another study that reported association between the T‐allele and CAD development . It appears that the relationship between this polymorphism and AMI is more significant among hypertensive and hypercholesterolemic patients . In our study cholesterol levels in AMI patients were not significantly different from the controls.…”

Section: Discussioncontrasting

confidence: 99%

“…These results are consistent with Palacin et al 7 but inconsistent with another study that reported association between the T-allele and CAD development. 5 It appears that the relationship between this polymorphism and AMI is more significant among hypertensive and hypercholesterolemic patients.…”

Section: Discussionsupporting

confidence: 70%

“…These results are consistent with Palacin et al . but inconsistent with another study that reported association between the T‐allele and CAD development .…”

Section: Discussionsupporting

confidence: 63%

“…EDN K198N is single nucleotide G‐to‐T polymorphism in endothelin gene causing Lys‐to‐Asn substitution . Some studies have reported an association between T allele and development of coronary artery disease (CAD) while a recent study reported a lack of association …”

Section: Introductionmentioning

confidence: 99%

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Assessment of the link between endothelin K198n Snp, endothelin concentration and acute myocardial infarction in Egyptians

Rahman

Abou-Aisha

Maksoud

2016

Clin Exp Pharma Physio

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The aim of the current study was to assess the link between EDN K198N SNP, ET-1 serum concentration and acute myocardial infarction (AMI) in Egyptians. The study cohort consisted of 84 patients at AMI onset and 84 age-matched healthy controls. Endothelin genotypes and concentrations were determined by sequencing and ELISA, respectively. Genotype distribution was not significantly different between AMI patients and controls (P=.8341). The mean serum ET-1 concentration of patients (13.83±0.7 pg/mL) was significantly higher than controls (7.26±0.2 pg/mL) (P<.0001). ET-1 serum concentrations did not vary significantly among various EDN genotypes in patients (P=.378) and controls (P=.6164). Hence, we conclude that EDN K198N genotypes were not related to either ET-1 concentration or incidence of early-onset AMI in Egyptians. But, AMI patients had higher ET-1 concentrations than controls.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionsupporting

confidence: 70%

“…These results are consistent with Palacin et al . but inconsistent with another study that reported association between the T‐allele and CAD development .…”

Section: Discussionsupporting

confidence: 63%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Assessment of the link between endothelin K198n Snp, endothelin concentration and acute myocardial infarction in Egyptians

Rahman

Abou-Aisha

Maksoud

2016

Clin Exp Pharma Physio

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“…demonstrated a lack of association between ET-1 gene variant and myocardial infarction. [13] High ET-1 level in both the patients who had or not an episode of myocardial infarction in our patients suggests that some other endothelium modulating factor is contributing to this fact. A similar finding was also observed among the patients who were either suffering or not from hypertension.…”

Section: Discussionmentioning

confidence: 71%

Does sleep quality affects the immediate clinical outcome in patients undergoing coronary artery bypass grafting: A clinico-biochemical correlation

et al. 2017

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Objective:Poor sleep quality is emerging as high prevalence among the patients suffering from cardiometabolic disturbances. The vascular polypeptide endothelin 1 (ET-1) is involved in many of the health disorders. However, its potential involvement in patients having poor sleep quality along with cardiovascular problem is limited. The present study was formulated to conduct a prospective analysis of the relationship between ET-1 and in hospital outcome in sleep disorder patients undergoing routine coronary artery bypass grafting (CABG).Methods:A total of 156 patients were enrolled and divided into two groups based on the Pittsburg Sleep Quality Index (PSQI) of ≤5 (Group I, n = 101) or >5 (Group II, n = 55). Blood sample was collected before anesthesia induction (ET-1a) and at 48 h (ET-1b) to analyze the plasma ET-1 and blood sugar level. The patients were monitored for any intraoperative adverse events and postoperative complications during their hospital stay.Results:Both groups were comparable in relation to age, sex, incidence of smoking and alcohol consumption. The distribution of comorbid conditions was also similar in both groups. The ET-1 level was higher in Group II than Group I before anesthesia induction as well as 48 h postoperatively (4.5 ± 1.75 vs. 10.61 ± 9.3, P = 0.001; 2.08 ± 1.3 vs. 8.3 ± 9.86, P = 0.0001, respectively). The Group II patients had a longer duration of mechanical ventilation (14.6 ± 12.05 vs. 10.1 ± 8.19, P = 0.001), Intensive Care Unit stay (2.08 ± 0.95 vs. 2.7 ± 1.45, P = 0016) and hospital stay (5.98 ± 1.73 vs. 7.8 ± 3.66, P = 0.0001, respectively). The high number of patients from Group II required inotrope and intra-aortic balloon pump support while compared with Group I (P ≤ 0.05 in each). The overall postoperative complication rate was significantly higher among patients with PSQI of >5 (Group II) except the rate of infection and neurological complications which was similar among both group of patients. The postoperative in hospital mortality was nil in Group I and 3.6% in Group II (P = 0.05). There was a strong relationship between PSQI and ET-1 at both the time points.Conclusion:Poor sleep quality associated with a higher incidence of adverse perioperative events in patients undergoing elective CABG. There exists a potential link between poor sleep quality and ET-1 in these groups of patients.

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Genetic variant in the 5ʹ untranslated region of endothelin1 (EDN1) gene in children with primary nephrotic syndrome

Yahia

Hammad

El‐Gilany

et al. 2021

J Biochem & Molecular Tox

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Endothelin-1 plays a crucial role in the pathophysiology of nephrotic syndrome (NS) in children. The primary purpose of this study is to evaluate the contribution of the EDN1 (3A/4A; rs1800997) variant to the risk of nephrotic syndrome. This study involves 200 participants (100 healthy controls, 50 steroid-sensitive nephrotic syndromes [SSNS] patients, and 50 steroid-resistant nephrotic syndromes [SRNS]

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Lack of Association between Endothelin-1 Gene Variants and Myocardial Infarction

Cited by 13 publications

References 42 publications

Assessment of the link between endothelin K198n Snp, endothelin concentration and acute myocardial infarction in Egyptians

Assessment of the link between endothelin K198n Snp, endothelin concentration and acute myocardial infarction in Egyptians

Does sleep quality affects the immediate clinical outcome in patients undergoing coronary artery bypass grafting: A clinico-biochemical correlation

Genetic variant in the 5ʹ untranslated region of endothelin1 (EDN1) gene in children with primary nephrotic syndrome

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