Lack of Association between Cytotoxic T-Lymphocyte Antigen-4 −318C/T Polymorphism and Cancer Risk: A Meta-Analysis of Case-Control Studies

Xia, Wei; Shi, Rong; Wen-ling, Zheng; Ma, Wenxue

doi:10.7785/tcrt.2012.500350

Cited by 2 publications

(1 citation statement)

References 48 publications

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“…Previous studies on the biological effects of miR-32 have mainly concentrated on tumors, viral replication and androgen regulation, which demonstrated that upon miR-32 overexpression, growth of the androgen-dependent prostate cancer cell line LNCaP was promoted. miR-32 has also been found to reduce apoptosis by directly regulating the expression of the BTG2 gene (55). Upregulation of miR-32 has been reported to inhibit the expression of apoptosis-inducing protein phosphoinositide-3-kinase interacting protein 1 and regulate the Ser/Thr protein kinase mitogen-activated protein kinase kinase, thus serving an important role in a variety of different signal transduction pathways (56).…”

Section: Discussionmentioning

confidence: 99%

Bone marrow stromal cells‑derived exosomes target DAB2IP to induce microglial cell autophagy, a new strategy for neural stem cell transplantation in brain injury

et al. 2020

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Bone marrow stromal cells (MSCs) are a useful source of stem cells for the treatment of various brain injury diseases due to their abundant supply and fewer ethical problems compared with transplant treatment. However, the clinical application of MSCs is limited due to allograft rejection and immunosuppression in the process of MSCs transplantation. According to previous studies, microglial cell autophagy occurs following co-culture with MSCs. In the present study, exosomes were obtained from MSCs and subsequently characterized using transmission electron microscopy, atomic force microscopy and dynamic light scattering particle size analysis. The type of microRNAs (miRs) found in the exosomes was then analyzed via gene chip. The results demonstrated that microglial cell autophagy could be induced by exosomes. This mechanism was therefore investigated further via reverse transcription-quantitative PCR, western blotting and luciferase assays. These results demonstrated that exosomes from MSCs could induce microglial cell autophagy through the miR-32-mediated regulation of disabled homolog 2-interacting protein, thus providing a theoretical basis for the clinical application of miRs in MSCs.

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Section: Discussionmentioning

confidence: 99%

Bone marrow stromal cells‑derived exosomes target DAB2IP to induce microglial cell autophagy, a new strategy for neural stem cell transplantation in brain injury

et al. 2020

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The association between cytotoxic T lymphocyte-associated antigen-4 and cervical cancer

Liu

Sun

et al. 2013

Tumor Biol.

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Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) gene polymorphisms have been associated with many autoimmune diseases and malignancy susceptibility, but the relationship between CTLA-4 and cervical cancer is still controversial. Hence, a meta-analysis of the published studies for the CTLA-4 gene polymorphisms and the risk of cervical cancer was performed to evaluate the association between them. Odds ratios (ORs) and 95% confidence intervals (CIs) for the codominant, dominant, and recessive genetic models were assessed. The fixed or random effect pooled measure was selected on the basis of the heterogeneity test among studies. The heterogeneity among studies was evaluated using the I (2). Eight studies with 2,835 cases and 2,560 controls were included. In seven studies for the CTLA-4 +49A/G polymorphism, a significant association was showed between the A allele and the increased risk of cervical cancer in the codominant (OR 1.16, 95% CI 1.05-1.29), dominant (OR 1.18, 95% CI 1.03-1.36), and recessive (OR 1.24, 95% CI 1.05-1.56) models. In five studies for the CTLA-4 -318C/T polymorphism, the meta-analysis showed a significant association of the C allele with the reduced risk of cervical cancer in the codominant (OR 0.79, 95% CI 0.66-0.94) and recessive (OR 0.76, 95% CI 0.63-0.93) models. This meta-analysis suggested that +49A/G and -318C/T polymorphisms of the CTLA-4 gene were significantly associated with the risk of cervical cancer. However, further studies are required to draw a solid conclusion on the relation between the CTLA-4 polymorphism and the risk of cervical cancer.

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Lack of Association between Cytotoxic T-Lymphocyte Antigen-4 −318C/T Polymorphism and Cancer Risk: A Meta-Analysis of Case-Control Studies

Cited by 2 publications

References 48 publications

Bone marrow stromal cells‑derived exosomes target DAB2IP to induce microglial cell autophagy, a new strategy for neural stem cell transplantation in brain injury

Bone marrow stromal cells‑derived exosomes target DAB2IP to induce microglial cell autophagy, a new strategy for neural stem cell transplantation in brain injury

The association between cytotoxic T lymphocyte-associated antigen-4 and cervical cancer

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