Lack of association between carotid intima-media thickness and apolipoprotein (a) isoforms in a sample of Spanish general population

Calmarza, Pilar; Trejo, José María; Lapresta, Carlos; López, Pilar

doi:10.1016/j.jjcc.2013.01.006

Cited by 11 publications

(12 citation statements)

References 37 publications

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“…Although the low-molecular-weight apo(a) phenotype is known to be associated with cardiovascular disease, several previous studies also found no association between KIV-2 repeat numbers and atherosclerosis. 37,38 A population-wide prospective study showed that low-molecular-weight apo(a) phenotypes were associated with advanced carotid atherosclerosis, but not with early carotid atherosclerosis. 10 So, it might be that KIV-2 repeat numbers affect especially plaque composition in patients with severe carotid atherosclerosis.…”

Section: Discussionmentioning

confidence: 99%

Lipoprotein(a) levels and atherosclerotic plaque characteristics in the carotid artery: The Plaque at RISK (PARISK) study

et al. 2021

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Section: Discussionmentioning

confidence: 99%

Lipoprotein(a) levels and atherosclerotic plaque characteristics in the carotid artery: The Plaque at RISK (PARISK) study

et al. 2021

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“… 22 An opposing report stated that CIMT was not associated with ApoA isoforms. 23 Furthermore, plasma ApoB levels were not an independent predictive indicator associated with ultrasonographic phenotypes of carotid atherosclerosis in patients with diabetes mellitus. 24 Our study showed that serum TC, TG, ApoA1, and ApoB levels were higher in alcohol-consuming subjects with increased CIMT; hence, increased CIMT was associated with age, BMI, TC, TG, ApoA1, and ApoB in subjects who consume alcohol.…”

Section: Discussionmentioning

confidence: 90%

Risk Factors Associated With Increased Carotid Intima-Media Thickness in a Male Population With Chronic Alcohol Consumption

Liu

et al. 2016

Medicine

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Previous studies have reported a relationship between alcohol consumption and carotid intima-media thickness (CIMT). However, the exact associations between different severities of CIMT and dyslipidemia, dyslipoproteinemia, inflammatory immune markers, and oxidative markers associated with chronic alcohol consumption remain unknown.The aim of this study was to explore whether there are associations between different severities of CIMT and dyslipidemia, dyslipoproteinemia, inflammatory immune markers, and oxidative markers associated with chronic alcohol consumption.We enrolled 173 males with chronic alcohol consumption and categorized them into 2 groups: 104 chronic alcohol consumers with normal CIMT (group A) and 69 chronic alcohol consumers with increased CIMT (group B).Nonparametric statistics showed that age, body mass index (BMI), and serum TC, TG, Apo A1, and ApoB levels were significantly higher in group B than in group A (P = 0.002, 0.019, 0.021, 0.023, 0.001, and 0.001, respectively). Additionally, tumor necrosis factor alpha (TNFα) and HSP70 serum levels were significantly lower in group B than in group A (P = 0.023 and 0.017, respectively). A binary logistic regression analysis showed that age (OR: 1.077, 95% CI: 1.024–1.13, P = 0.004), ApoB (OR: 6.828, 95% CI: 1.506–30.956, P = 0.013), and TNF-α (OR: 0.999, 95% CI: 0.998–1.00) were independent risk factors associated with CIMT.The present study demonstrated that age, ApoB, and TNFα are independent risk factors associated with CIMT. Thus, older subjects with increased serum ApoB levels are more likely to present with increased CIMT, suggesting that age and ApoB promote such thickening and that TNFα downregulation might play a protective role against the progression of subclinical atherosclerosis in subjects with chronic alcohol consumption.

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“…While Kotani and Sakane 35 have found an inverse association in the Japanese population, no relationship between that thickness and Lp(a) levels has been found in Spaniards by Calmarza et al 36 . …”

Section: Lp(a) Pathophysiologymentioning

confidence: 87%

Lipoprotein (a): Structure, Pathophysiology and Clinical Implications

Maranhão¹,

Carvalho²,

Strunz³

et al. 2014

Arquivos Brasileiros De Cardiologia

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The chemical structure of lipoprotein (a) is similar to that of LDL, from which it differs due to the presence of apolipoprotein (a) bound to apo B100 via one disulfide bridge. Lipoprotein (a) is synthesized in the liver and its plasma concentration, which can be determined by use of monoclonal antibody-based methods, ranges from < 1 mg to > 1,000 mg/dL. Lipoprotein (a) levels over 20-30 mg/dL are associated with a two-fold risk of developing coronary artery disease. Usually, black subjects have higher lipoprotein (a) levels that, differently from Caucasians and Orientals, are not related to coronary artery disease. However, the risk of black subjects must be considered. Sex and age have little influence on lipoprotein (a) levels. Lipoprotein (a) homology with plasminogen might lead to interference with the fibrinolytic cascade, accounting for an atherogenic mechanism of that lipoprotein. Nevertheless, direct deposition of lipoprotein (a) on arterial wall is also a possible mechanism, lipoprotein (a) being more prone to oxidation than LDL. Most prospective studies have confirmed lipoprotein (a) as a predisposing factor to atherosclerosis. Statin treatment does not lower lipoprotein (a) levels, differently from niacin and ezetimibe, which tend to reduce lipoprotein (a), although confirmation of ezetimibe effects is pending. The reduction in lipoprotein (a) concentrations has not been demonstrated to reduce the risk for coronary artery disease. Whenever higher lipoprotein (a) concentrations are found, and in the absence of more effective and well-tolerated drugs, a more strict and vigorous control of the other coronary artery disease risk factors should be sought.

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Lack of association between carotid intima-media thickness and apolipoprotein (a) isoforms in a sample of Spanish general population

Abstract: In this sample of the general Spanish population, no association was found between apolipoprotein (a) isoforms and carotid artery intima-media thickness.

Cited by 11 publications

References 37 publications

Lipoprotein(a) levels and atherosclerotic plaque characteristics in the carotid artery: The Plaque at RISK (PARISK) study

Lipoprotein(a) levels and atherosclerotic plaque characteristics in the carotid artery: The Plaque at RISK (PARISK) study

Risk Factors Associated With Increased Carotid Intima-Media Thickness in a Male Population With Chronic Alcohol Consumption

Lipoprotein (a): Structure, Pathophysiology and Clinical Implications

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