Lack of allergenic cross‐reactivity between storage mites and Dermatophagoides pteronyssinus

Abstract

Summary The allergenic cross‐reactivity between storage mites (Lepidoglyphus destructor, Glycyphagus domesticus, Tyrophagus putrescentiae and Acarus siro) and the house dust mite Dermatophagoides pteronyssinus was studied with the radio‐allergo‐sorbent test (RAST) and the RAST inhibition technique. RAST‐positive sera were obtained from fifty‐three farmers who were positive to at least one of the four storage mites. Sera from twelve of these farmers, eight of whom were also positive to D. pteronyssinus, were investigated with the RAST inhibition technique. No significant correlations were found between IgE‐antibody levels to any single storage mite and D. pteronyssinus. There was no correlation between the RAST results to A. siro and G. domesticus, whereas a significant correlation was found between L. destructor, G. domesticus and T. putrescentiae. The RAST inhibition studies confirmed the greater allergenic similarity between L. destructor, G, domesticus and T. putrescentiae than between A. siro and the other three storage mites. The results of our studies support the hypothesis that each of the storage mites and D. pteronyssinus possess their own unique allergen or allergens. Furthermore, L. destructor, G. domesticus and T. putrescentiae seem to be allergenically more closely related to each other than to A. siro.

Demonstration of Allergen Components in the Storage Mite <i>Lepidoglyphus destructor</i> by an Immunoblotting Technique

“…We have recently reported a finding of lack of al lergenic cross-reactivity between storage mites and the house dust mite D.pteronyssinus as studied by RAST inhibition [18]. We found no significant aller genic cross-reactivity between the house dust mite and the four storage mites L. destructor.…”

“…We studied the allergenic cross-reactivity between storage mites and the house dust mite D. pteronyssinus by radioallergosorbent test (RAST) inhibition [18]. The four storage mites L. destructor, T. putrescentiae, Glycyphagus domesticus and Acarus siro seemed to share some common or related allergens, but there was no significant allergenic cross-reactivity between the four storage mites and D. pteronyssinus.…”

Prevalence of <i>Tyrophagus putrescentiae</i> Hypersensitivity in Subjects over 70 Years of Age in a Veterans’ Nursing Home in Taiwan

“…It has been suggested that Tp and Dp possess their own unique allergens [22]. It is conceivable that the allergens in Tp might be different from those in Dp.…”

Allergen cross‐reactivity between house‐dust mites and other invertebrates

“…Most reports con®rm that HDM extracts inhibit storage-mite-speci®c IgE-binding (A. siro, T. putrescentiae, L. destructor) and vice versa (61, 62, 66, 67, 74±77); one study even found no cross-reactivity (73). HDM seem to cross-react more strongly to A. siro and T. putrescentiae than to L. destructor (61).…”