Laboratory Methods and Management of Patients with Heparin-Induced Thrombocytopenia

Abstract

The clinical effects of heparin are meritorious and heparin remains the anticoagulant of choice for most clinical needs. However, as with any drug, adverse effects exist. Heparin-induced thrombocytopenia (HIT) is an important adverse effect of heparin associated with amputation and death due to thrombosis. Although the diagnosis and treatment of HIT can be difficult and complex, it is critical that patients with HIT be identified as soon as possible to initiate early treatment to avoid thrombosis.

Heparin-Induced Thrombocytopenia

“…These are platelet function tests (serotonin release and platelet aggregation assays) and immunoassays that detect antibodies to the PF4-heparin complex. 61 –64 Each test has particular performance characteristics and provides unique information, so that appropriate use and knowledgeable interpretation of the test results are important. 64 –67 Platelet function assays that use washed platelets have a better sensitivity than plasma-based assays, but false negative results can still be obtained.…”

Erratum

“…61 –64 Each test has particular performance characteristics and provides unique information, so that appropriate use and knowledgeable interpretation of the test results are important. 64 –67 Platelet function assays that use washed platelets have a better sensitivity than plasma-based assays, but false negative results can still be obtained. Immunoassays have a high rate of positive results that are not always associated with clinical HIT in the patient.…”