Laboratory investigations in uveitis: current practice and future directions

Majumder, Parthopratim Dutta; Palkar, Amit H; Annamalai, Radha; Biswas, Jyotirmay

doi:10.1016/j.jcjo.2018.02.003

Cited by 4 publications

(2 citation statements)

References 34 publications

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“…Hence, there is a need for eliciting a detailed history and performing a meticulous clinical evaluation, of both the eyes as well as other organs of the body. A tailored approach to laboratory investigations based on meticulous history and comprehensive ocular evaluation has been considered the gold standard for the successful management of uveitis [6] . The choice of investigations should be based on clinical clues, available standard guidelines, and strength of evidence so as to prevent additional financial burden to the patient as well as reduce the risks associated with obtaining a false positive result.…”

Section: Introductionmentioning

confidence: 99%

First contact investigations and compliance to treatment in patients with uveitis

Patil,

Venkatesh,

Banerjee

et al. 2023

Int J Ophthalmol

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AIM: To ascertain the pattern of investigations at first contact in uveitic patients and evaluate compliance to treatment. METHODS: An observational study comprised of 201 uveitic patients presenting for the first time to our centre from January 2019 to June 2020. Detailed information regarding systemic investigations undertaken by specialists at the time of first contact and the cost of these investigations were reviewed on the first visit to our centre. Compliance with the treatment was determined and reasons behind non-compliance were evaluated on the first follow-up in patients who had no improvement in clinical signs and symptoms. RESULTS: The mean age of the study group was 35.35±14.1y and gender composition was 59.7% males and 40.3% females. Anterior uveitis was observed in 45.3% of patients, intermediate uveitis in 31.8% of patients, posterior uveitis in 14.9% of patients and panuveitis in 8.0% of patients. Association with a systemic disease was evident in 17.9% of patients. When compared with standard guidelines and uveitis patterns, systemic investigations were identified to be relevant only in 38.3% of patients. Non-compliance to treatment was documented in 22.4% of patients. Common reasons for non-compliance were inadequate counselling by the treating physician about treatment in 26.7% of patients and a busy schedule at work/school in 22.2% of patients. CONCLUSION: Significant number of investigations performed at first contact is found to be contrary to standard guidelines and are not contributory to the care. About a quarter of patients in this study are found to be non-compliant with the treatment. Compliance is more challenging to achieve in school-going children and working adults. The availability of comprehensive, periodically updated, evidence-based guidelines on the role of investigations and the use of trained counsellors may help to channelize proper evaluation and improve compliance to treatment, respectively, in patients with uveitis.

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Section: Introductionmentioning

confidence: 99%

First contact investigations and compliance to treatment in patients with uveitis

Patil,

Venkatesh,

Banerjee

et al. 2023

Int J Ophthalmol

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“…A detailed uveitis oriented history, along with a thorough and complete ophthalmic examination Review 1 Professor and Director, Department of Uveitis and Ocular Pathology, 2 Observer, Department of Uvea, Sankara Nethralaya, Chennai, India.…”

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confidence: 99%

Uuveitis – search for the cause

Biswas

Nallagula

2021

J. Coll. Ophthal. SL

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Etiological diagnosis of uveitis remains a challenge in spite of all the advancement in the knowledge of uveitis. It's often a challenging task on the part of the clinician to decide which laboratory test needs to be performed. Lack of tailored approach to laboratory investigation can become huge economic burden on the patients. Investigation of uveitis is an important component in diagnosis and management of uveitis. This includes a thorough review of the patient's previous medical records and accurate assessment of the disease at each clinic visit. A complete review of the patient's medical records provides important information for planning new therapeutic approaches and guards against repeating therapies that were unsatisfactory in the past. It is required to identify specific uveitic entities like toxoplasma retinichoroiditis, to obtain diagnostic and prognostic information and to take therapeutic decision. For example in HLA-B27 positive anterior uveitis, uveitis would be recurrent and can present with fibrin and hypopyon.

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