Laboratory in Diagnosis and Monitoring of Systemic Inflammatory Response Syndrome or Sepsis

Aral, Hale

doi:10.15197/sabad.2.5.02

Cited by 1 publication

(1 citation statement)

References 61 publications

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“…However, its concentrations also increase during the infection, anorexia, high fever and increased protein catabolism [36] . In addition to these, systemic inflammation that develops in the infections, disturb kidney perfusion and impair its filtration capability, resulting with increase in blood urea and creatinine [37] . In this study, serum urea and creatinine levels were also increased and it was thought that this might be caused by an increase in protein catabolism or impaired renal function due to systemic inflammation.…”

Section: Discussionmentioning

confidence: 99%

Poksvirüs İle Doğal Enfekte Koyunlarda, Bazı Akut Faz Proteinler, Biyokimyasal Parametreler ve Oksidatif Stresin Belirlenmesi

Bozukluhan¹,

Merhan²,

Gokce³

et al. 2018

Kafkas Univ Vet Fak Derg

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The aim of the present study was to determine oxidative stress and acute phase response in naturally infected sheep with poxvirus. For this purpose, 20 poxvirus infected and 10 clinically healthy sheep were used in the study. In these animals, alkaline phosphatase (ALP), aspartate aminotransferase (AST) activity, haptoglobin, ceruloplasmin, urea, creatinine, albumin, iron (Fe), malondialdehyde (MDA) and reduced glutathione (GSH) concentrations were determined. The present study determined that the concentrations of haptoglobin, ceruloplasmin, urea, creatinine, MDA and ALP, AST activity were significantly increased, and albumin, Fe and GSH concentrations were significantly decreased in the sheeppox virus infected group compared to the control group. Results of this study indicated that oxidative stress and acute phase response develop in sheep infected with poxvirus. Keywords: Acute phase proteins, Biochemical parameters, Sheeppox Poksvirüs İle Doğal Enfekte Koyunlarda, Bazı Akut Faz Proteinler, Biyokimyasal Parametreler ve Oksidatif Stresin Belirlenmesi ÖzÇalışma poksvirüs ile doğal enfekte koyunlarda, oksidatif stres ve akut faz cevabı belirlemek amacıyla yapıldı. Çalışmada 20 adet çiçek hastalığı ile enfekte ve 10 adet klinik olarak sağlıklı koyun kullanıldı. Hayvanlarda alkalen fosfataz (ALP), aspartat aminotransferaz (AST) aktivitesi, haptoglobin, seruloplazmin, üre, kreatinin, albümin, demir (Fe), malondialdehit (MDA) ve redükte glutatyon (GSH) konsantrasyonları belirlendi. Çalışmada, poksvirus ile enfekte koyunlar ile kontrol grubundaki hayvanlar karşılaştırıldığında haptoglobin, seruloplazmin, üre, kreatinin, MDA değerleri ile ALP ve AST aktivitelerinin yükseldiği, albümin, Fe ve GSH konsantrasyonunun ise kontrol grubuna göre düştüğü belirlendi. Bu çalışmada poksvirus ile enfekte koyunlarda akut faz yanıtın oluştuğu ve oksidatif stresin geliştiği kanısına varıldı.

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Section: Discussionmentioning

confidence: 99%