Laboratory Diagnosis of Asian Influenza

Jensen, Keith E.; Hogan, Ralph B.

doi:10.2307/4590063

Cited by 12 publications

(5 citation statements)

References 5 publications

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“…Thus with the pure substrains there is a positive correlation between sensitivity to antibodies and sensitivity to normal serum inhibitors. A similar correlation between sensitivity to serum inhibitors and sensitivity to specific antibodies has been found by many workers with strains of influenza A2 virus (4)(5)(6)(7)(8)20).…”

Section: Interactions Of Substrains and Strains With Antibody Andsupporting

confidence: 82%

Studies of Two Kinds of Virus Particles Which Comprise Influenza A2 Virus Strains

Choppin

Tamm

1960

The Journal of Experimental Medicine

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Two kinds of virus particles have been found in varying proportions in influenza A2 strains isolated during the 1957 pandemic. Pure populations of the different particles were obtained, and these substrains were genetically stable on serial passage in the chick embryo. The two virus particles differ markedly in several biological properties though they are antigenically similar. One kind of particle, designated "+," is relatively sensitive to specific antibody, is highly sensitive to inhibition by serum inhibitors and urinary mucoprotein, fails to elute or elutes very slowly from human erythrocytes, and is capable of agglutinating erythrocytes treated extensively with V. cholerae filtrate. The other particle, designated "-," is relatively insensitive to antibodies and urinary mucoprotein, completely insensitive to serum inhibitors, elutes rapidly from erythrocytes, and can agglutinate erythrocytes treated extensively with V. cholerae filtrate. Both "+" and "-" particles destroy virus receptors on urinary mucoprotein. The relative proportions of these two particles determine the characteristics of parent strains in reactions with specific antibody, mucoprotein inhibitors, and erythrocytes. The "+" and "-" particles with several easily identifiable markers are well suited for genetic studies.

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Section: Interactions Of Substrains and Strains With Antibody Andsupporting

confidence: 82%

Studies of Two Kinds of Virus Particles Which Comprise Influenza A2 Virus Strains

Choppin

Tamm

1960

The Journal of Experimental Medicine

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“…The present study supports the finding of Jensen and Hogan that multiple serologic methods are necessary for the maximum diagnosis of cases of influenza (17). Despite the use of three methods, significant antibody response was not demonstrated in nine patients who developed clinical illness indistinguishable from the serologically confirmed influenza of others.…”

Section: Bacteriologic Studiessupporting

confidence: 77%

Studies on Influenza in the Pandemic of 1957-1958. I. An Epidemiologic, Clinical and Serologic Investigation of an Intrahospital Epidemic, With a Note on Vaccination Efficacy*

Blumenfeld¹,

Kilbourne²,

Louria³

et al. 1959

J. Clin. Invest.

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“…El diagnóstico de la enfermedad se ejecutó mediante pruebas serológicas de laboratorio. La identificación de anticuerpos contra el antígeno viral del subtipo H2N2 a partir de suero de personas afectadas se realizó con la técnica de fijación del complemento (FC) y la prueba de inhibición de la hemaglutinación (HAI) con el uso de tripsina y periodato de potasio para la inactivación de inhibidores específicos 19,20 . Los estudios y la experiencia de campo demostraron que la FC presentó mayor sensibilidad, sin embargo, existieron casos en los que se requirieron de las dos técnicas para un diagnóstico confirmatorio 20 .…”

Section: Epidemias Y Pandemias Importantes a Partir De 1950unclassified

Herramientas biotecnológicas en el diagnóstico, prevención y tratamiento frente a pandemias

Molina

Arias

2021

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Las pandemias son consideradas como un problema emergente de salud pública a nivel mundial, las cuales además de caracterizarse por tasas altas de morbilidad y mortalidad, ocasionan conflictos en los aspectos sociales, económicos y políticos. Las herramientas biotecnológicas, por su parte, han ido evolucionando conforme al avance tecnológico-científico, lo que ha permitido optimizar métodos de diagnóstico con alta sensibilidad y especificidad, además de mejorar el desarrollo de productos biológicos para la prevención y terapia de enfermedades. El objetivo de esta revisión es identificar la actualización de las herramientas biotecnológicas en el diagnóstico, tratamiento terapéutico y profiláctico frente a los patógenos causantes de las enfermedades pandémicas a lo largo de la historia, mediante la recopilación de información científica. Con este estudio se logró establecer que las herramientas y productos de origen biotecnológico han constituido un papel fundamental en el control de pandemias a través de la innovación constante que ha permitido alcanzar resultados eficientes tanto en diagnóstico como en el tratamiento.

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Laboratory Diagnosis of Asian Influenza

Cited by 12 publications

References 5 publications

Studies of Two Kinds of Virus Particles Which Comprise Influenza A2 Virus Strains

Studies of Two Kinds of Virus Particles Which Comprise Influenza A2 Virus Strains

Studies on Influenza in the Pandemic of 1957-1958. I. An Epidemiologic, Clinical and Serologic Investigation of an Intrahospital Epidemic, With a Note on Vaccination Efficacy*

Herramientas biotecnológicas en el diagnóstico, prevención y tratamiento frente a pandemias

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