Laboratory Criteria of the Cure of Typhoid Carriers

Abstract

MOST reports on the cure of typhoid carriers by cholecystectomy give the impression that only three-quarters of the operations, or less, succeed in eliminating the focus of the bacilli,1 2, 3 although some report better results.4

Development and evaluation of an enzyme-linked immunosorbent assay for serum Vi antibodies for detection of chronic Salmonella typhi carriers

“…The PHA was performed for each subject in each group by previously described methods (6). A titer of .160 was considered to be indicative of the S. typhi carrier state.…”

“…These procedures are not amenable to largescale screening (6, 7, 10). In addition, because chronic biliary carriers are often intermittent or light fecal S. typhi excreters, multiple bacteriological examinations are usually required to make a reliable diagnosis (3,6,10). For these reasons, serological screening for the carrier state of S. typhi in areas of typhoid endemicity is preferable.…”