Laboratory-based versus qualitative assessment of α-defensin in periprosthetic hip and knee infections: a systematic review and meta-analysis

Balato, Giovanni; Matteo, Vincenzo de; Ascione, Tiziana; Donato, Sigismondo Luca Di; Franco, Cristiano De; Smeraglia, Francesco; Baldini, Andrea; Mariconda, Massimo

doi:10.1007/s00402-019-03232-5

Cited by 36 publications

(27 citation statements)

References 42 publications

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“…Interestingly, the most popular diagnostic test applied in recent years was synovial fluid alpha-defensin, which also had the highest sensitivity. Accordingly, pooled results supported the higher sensitivity of the synovial fluid alpha-defensin immunoassay compared to the lateral flow test[14][15][16][17]. Preoperative tests with the lowest sensitivities were synovial fluid gram staining (GS), synovial fluid procalcitonin (PCT), serum white blood cells (WBCs), serum PCT, which were all found to have a sensitivity of less than 60%.…”

mentioning

confidence: 72%

“…48 (69). The month with the highest number of publications received was May (13), closely followed by March (11), and June (10), whereas the day with the highest number of publications received was Wednesday (24), pursued by Friday (16), and Tuesday (14). Most papers were accepted during February (12), October (11), and August (10),…”

Section: First Authormentioning

confidence: 99%

“…From 40 diagnosis-related meta-analyses, 72 tests were related to preoperative examination, followed by intraoperative methods (12), and test prior to reimplantation (14). Synovial fluid alphadefensin had highest pooled sensitivities in the list of preoperative examinations, pursued by serum IL-6 and bone scintigraphy.…”

Section: Diagnosis Of Pjimentioning

confidence: 99%

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Meta-analysis in periprosthetic joint infection: a global bibliometric analysis

Thies

et al. 2020

Preprint

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Background: Periprosthetic joint infection (PJI) is the most serious complication of joint replacement surgery. Further comorbidities include bedsore, deep vein thrombosis, reinfection, or even death. An increasing number of researchers are focusing on this challenging complication. The aim of the present study was to estimate global PJI research based on bibliometrics from meta-analysis studies. Methods: A database search was performed in PubMed, Scopus, and Web of Science. Relevant studies were assessed using the bibliometric analysis. Results: A total of 117 articles were included. The most relevant literature on PJI was found on Scopus. China made the highest contributions to global research, followed by the United States and the United Kingdom. The institution with the most contributions from the University of Bristol. The journal with the highest number of publications was The Journal of Arthroplasty, whereas the Journal of Clinical Medicine had the shortest acceptance time. The day of the week with the greatest number of received and accepted manuscripts was Wednesday. Furthermore, the top three frequently used databases were Embase, MEDLINE, and Cochrane. The most frequent number of authors in meta-analysis studies was four. Most studies focused on the periprosthetic hip and knee. The alpha-defensin diagnostic test, preventive measures on antibiotics use, and risk factors of intra-articular steroid injections were the most popular topic in recent years. Conclusion: Based on the results of the present study, we found that there was no single database covered all relevant articles, the optimal method for bibliometric analysis is a combination of databases. The most popular research topics on PJI focused on alpha-defensin, antibiotic use, risk factors of intra-articular steroid injections, and the location of prosthetic hip and knee infection. Alpha-defensin appears to be a reliable tool for the diagnosis of PJI.

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mentioning

confidence: 72%

Section: First Authormentioning

confidence: 99%

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Meta-analysis in periprosthetic joint infection: a global bibliometric analysis

Thies

et al. 2020

Preprint

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“…Embase was the most described database (101), followed by MEDLINE (80), and Cochrane (74; Table 9). Three databases were most frequently searched (40), followed by four (22), and five (16). The most combined database group was Cochrane Library + Embase + MEDLINE/PubMed (10), followed by Embase + MEDLINE (6), and Cochrane Library + Embase + MEDLINE + Web of Science (5).…”

Section: Database and Softwarementioning

confidence: 99%

Meta-analysis in periprosthetic joint infection: a global bibliometric analysis

Ojeda-Thies

et al. 2020

J Orthop Surg Res

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Background: Periprosthetic joint infection (PJI) is the most serious complication of joint replacement surgery. Further comorbidities include bedsore, deep vein thrombosis, reinfection, or even death. An increasing number of researchers are focusing on this challenging complication. The aim of the present study was to estimate global PJI research based on bibliometrics from meta-analysis studies. Methods: A database search was performed in PubMed, Scopus, and Web of Science. Relevant studies were assessed using the bibliometric analysis. Results: A total of 117 articles were included. The most relevant literature on PJI was found on Scopus. China made the highest contributions to global research, followed by the USA and the UK. The institution with the most contributions was the University of Bristol. The journal with the highest number of publications was The Journal of Arthroplasty, whereas the Journal of Clinical Medicine had the shortest acceptance time. Furthermore, the top three frequently used databases were Embase, MEDLINE, and Cochrane. The most frequent number of authors in metaanalysis studies was four. Most studies focused on the periprosthetic hip and knee. The alpha-defensin diagnostic test, preventive measures on antibiotics use, and risk factors of intra-articular steroid injections were the most popular topic in recent years. Conclusion: Based on the results of the present study, we found that there was no single database that covered all relevant articles; the optimal method for bibliometric analysis is a combination of databases. The most popular research topics on PJI focused on alpha-defensin, antibiotic use, risk factors of intra-articular steroid injections, and the location of prosthetic hip and knee infection.

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“…Most prominently antimicrobial peptides released by epithelial and other parenchymal cells exhibit the ability to destroy bacteria [44]. Ongoing efforts in experimental medicine are directed to use the antimicrobial capacity of peptides like defensins to treat specific infectious diseases [3]. The defense armory of parenchymal cells includes in addition phagocytosis of microbes and degradation by specific release of proteolytic enzymes or reactive oxygen species [12].…”

Section: Outlook: Resistance and Tolerance Responses Beyond The Immunmentioning

confidence: 99%