Laboratory-based ROTEM® analysis: implementing pneumatic tube transport and real-time graphic transmission

Colucci, Giuseppe; Giabbani, Evelyne; Barizzi, Gabriella; Urwyler, Natalie; Alberio, Lorenzo

doi:10.1111/j.1751-553x.2011.01303.x

Cited by 22 publications

(20 citation statements)

References 8 publications

(13 reference statements)

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“…In addition, our results show a difference already between manual and standard " priority " mode and this difference slightly increases with acceleration and rotation forces. These results are discrepant but not contradictory to our previously published work (14) because the studies are conducted at two different institutions with different tube transport systems and different acceleration forces.…”

Section: Discussioncontrasting

confidence: 99%

“…This study reinforces the thesis, that comparison of manual and local pneumatic delivery should be performed to exclude relevant in vitro blood coagulation activation (14) . At each institution an evaluation of the transport system is necessary before samples are routinely transported with a pneumatic tube system.…”

Section: Discussionsupporting

confidence: 86%

“…To assure quality of analysis, blood coagulation activation by acceleration and deceleration along the trajectory in the pneumatic tube delivery system should be excluded. Comparison of manual and pneumatic delivery of blood samples should be performed to exclude pre-analytical infl uences (13,14) . The fi rst aim of the present study was to investigate the effect of transport on ROTEM ® parameters.…”

Section: Discussionmentioning

confidence: 99%

“…The reagents, stored at temperatures between 4 ° C and 8 ° C, were kept at room temperature for 10 min and shaken gently before pipetted. INTEM, EXTEM, FIBTEM and APTEM test were performed as described previously (14) . For each analysis standard ROTEM ® parameters, such as clotting time (CT, s), A5 (clot thickness after 5 min, mm), A10 (clot thickness after 10 min, mm), A15 (clot thickness after 15 min, mm), A30 (clot thickness after 30 min, mm), clot formation time (CFT, s), maximum clot fi rmness (MCF, mm), alpha ( α , angle) LI30 (lysis index after 30 min), LI45 (lysis index after 45 min), ML (maximal lysis) and AUC (area under the curve) were measured.…”

Section: Rotem ® Analysismentioning

confidence: 99%

“…Pre-analytical effects of pneumatic tube transport on coagulation parameters and platelet function have also been evaluated (10 -12) . Finally, each pneumatic transport system possesses a unique technical and structural pattern and should be tested for pre-analytical effects (13) , including effects with regard to ROTEM ® analysis (14) . Indeed the manufacturer of the ROTEM ® delta device advises against the transport of blood samples via pneumatic tube unless the infl uence of local mechanical transport system is investigated.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Effect of acceleration forces during transport through a pneumatic tube system on ROTEM® analysis

Amann

Zehntner²,

Marti³

et al. 2012

Clinical Chemistry and Laboratory Medicine

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Background: ROTEM ® is considered a helpful point-of-care device to monitor blood coagulation in emergency situations. Centrally performed analysis is desirable but rapid transport of blood samples is an important prerequisite. The effect of acceleration forces on sample transport through a pneumatic tube system on ROTEM ® should be tested at each institution to exclude a pre-analytical infl uence. The aims of the present work were: (i) to investigate the effect of pneumatic tube transport on ROTEM ® parameters; (ii) to compare blood sample transport via pneumatic tube vs. manual transportation; and (iii) to determine the effect of acceleration forces on ROTEM ® parameters. Methods: This is a single centre study with 20 healthy volunteers. Five whole blood samples were transferred to the central haematology laboratory by either normal transport or pneumatic delivery with different speed and acceleration forces. EXTEM, INTEM, FIBTEM and APTEM were analysed in parallel with two ROTEM ® devices and compared. Acceleration forces were measured during transport with two different instruments. Results: Increment of transport time, speed and distance resulted in an augmentation of acceleration forces and peaks. All results of the ROTEM ® analysis after manual transport or pneumatic delivery were within normal range. However, increase in acceleration forces resulted in minimally but statistically signifi cant changes in multiple ROTEM ® parameters. The higher the acceleration forces, the more ROTEM ® parameters are infl uenced. Conclusions: Acceleration forces during transport through a pneumatic tube system have an infl uence on ROTEM ® parameters. Prior to transfer blood samples via pneumatic tube system these infl uences should be tested to exclude clinically relevant blood coagulation activation in vitro.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Section: Rotem ® Analysismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Effect of acceleration forces during transport through a pneumatic tube system on ROTEM® analysis

Amann

Zehntner²,

Marti³

et al. 2012

Clinical Chemistry and Laboratory Medicine

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Electrochemical Biosensors Based on Micro‐fabricated Devices for Point‐of‐Care Testing: A Review

Zhang

Zhou

2021

Electroanalysis

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Point-of-care testing (POCT) is becoming a hot research topic that allows rapid, on-site, and non-professional measurements outside the central laboratory. The micro-fabricated devices prepared by various micromachining technologies have shown the advantages of low reagent consumption, high-throughput samples, and wearability. This review presents the recent progress of electrochemical biosensors based on various micro-fabri-cated devices for POCT and the corresponding electrochemical techniques. Signal amplification strategies based on enzyme and nanotechnology are also illustrated for the more sensitive POCT applications of these micro-fabricated devices. Consequently, the trends and challenges of electrochemical biosensors based on micro-fabricated devices in POCT diagnosis are discussed.

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Gerinnungsdiagnostik

Peetz¹,

Koscielny²,

Spannagl³

2017

POCT - Patientennahe Labordiagnostik

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Laboratory-based ROTEM® analysis: implementing pneumatic tube transport and real-time graphic transmission

Cited by 22 publications

References 8 publications

Effect of acceleration forces during transport through a pneumatic tube system on ROTEM® analysis

Effect of acceleration forces during transport through a pneumatic tube system on ROTEM® analysis

Electrochemical Biosensors Based on Micro‐fabricated Devices for Point‐of‐Care Testing: A Review

Gerinnungsdiagnostik

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