2010
DOI: 10.1093/humupd/dmq014
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Laboratory and embryological aspects of hCG-primed in vitro maturation cycles for patients with polycystic ovaries

Abstract: The data from the meta-analyses suggests that the effect on clinical outcome of gonadotrophin priming of IVM still needs to be studied. In order to improve the IVM programs, it is essential to define not only the clinical aspects but also the laboratory and embryological aspects.

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Cited by 98 publications
(98 citation statements)
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“…Many factors affecting in vitro maturation rate have been reported. It has been demonstrated that priming of ovarian immature oocytes with follicle-stimulating hormone or human chorionic gonadotrophin prior to immature oocyte retrieval improves oocyte maturation rates and embryo quality as well as pregnancy rates in infertile women with polycystic ovaries or polycystic ovary syndrome [20,21]. The size of the follicles may also be important for the subsequent embryonic development, while the developmental competence of oocytes derived from the small antral follicles is not adversely affected by the presence of a dominant follicle [22].…”
Section: Discussionmentioning
confidence: 99%
“…Many factors affecting in vitro maturation rate have been reported. It has been demonstrated that priming of ovarian immature oocytes with follicle-stimulating hormone or human chorionic gonadotrophin prior to immature oocyte retrieval improves oocyte maturation rates and embryo quality as well as pregnancy rates in infertile women with polycystic ovaries or polycystic ovary syndrome [20,21]. The size of the follicles may also be important for the subsequent embryonic development, while the developmental competence of oocytes derived from the small antral follicles is not adversely affected by the presence of a dominant follicle [22].…”
Section: Discussionmentioning
confidence: 99%
“…The nuclear maturity of the collected oocytes was assessed under the dissecting microscope with high magnification (x80) using the spreading method [12]. If no germinal vesicle (GV) was observed in the oocyte cytoplasm, the cumulus masses were removed with hyaluronidase and mechanical pipetting was carried out after the oocyte retrieval was completed.…”
Section: In Vitro Maturationmentioning
confidence: 99%
“…Several studies have reported pregnancies after IVM in PCOS with unstimulated cycles, also in cycles with FSH and hCG priming [2][3][4][5]. We believe that this is the first case report in which FSH priming was delayed until 13 th day of the cycle, when endometrial thickness reached 7 mm by endogenous estrogen.…”
Section: Discussionmentioning
confidence: 78%
“…In recent years, many improvements have been made in clinical and laboratory aspects of IVM treatment which have resulted in better pregnancy outcomes [4]. It was shown that pretreatment with FSH in the early days of folliculogenesis phase may increase the number of retrieved immature oocytes and/or maturation potential [5,6].…”
Section: Introductionmentioning
confidence: 99%
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