Fertilization, embryo development, and clinical outcome of immature oocytes obtained from natural cycle in vitro fertilization

Son, Weon‐Young; Chung, Jin‐Tae; Das, Mausumi; Buckett, William; Demirtaş, Ezgi; Holzer, Hananel

doi:10.1007/s10815-012-9889-5

Cited by 12 publications

(12 citation statements)

References 18 publications

(27 reference statements)

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“…Previous studies have demonstrated the influence of oocyte maturation on the rate of blastocyst formation. Immature oocytes, in addition to having a lower fertilization rate and lower blastocyst formation rate, have higher implantation failure and abortion rates (Kedem et al, 2018;Son et al, 2013;Zhao et al, 2009;Shu et al, 2007). De Vos et al (1999) and Alcoba et al (2015) did not evaluate the rate of blastocyst formation in their studies; they evaluated the cleavage rate in D2 and D3, and found that the cleavage rates were similar between embryos from MII oocytes and those from MI-MII oocytes, demonstrating that in vitro-matured oocytes also have the ability to generate good-quality embryos.…”

Section: Discussionmentioning

confidence: 99%

The usefulness of metaphase I oocytes in women who undergo controlled ovarian hyperstimulation for intracytoplasmic sperm injection

Bilibio

Lorenzzoni

Meireles

et al. 2020

JBRA Assisted Reproduction

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Objective: The aim of this study was to evaluate the fertilization and blastocyst formation rates of oocytes in metaphase I (MI) obtained from women who underwent controlled ovarian hyperstimulation (COH) for intracytoplasmic injection. Methods: A prospective cohort study that included women from whom at least 1 MI and 1 MII oocyte were obtained after COH was performed. We collected 1,907 oocytes from 164 women (1291 MII, 352 MI and 258 prophase I or atretic). After oocyte classification, the MII and MI oocytes were incubated for 4 hours. Results: After 4 hours, the rescue maturation rate was 57.2%; 205 MI oocytes matured to MII oocytes in vitro (rescued MI-MII group), and 153 remained in MI (arrested MI group). The normal fertilization rates were directly associated with oocyte maturation, with rates of 79.1%, 60.2%, and 31.9% in MII, MI-MII and MI oocytes, respectively (p<0.001). Group arrested MI had an odds ratio (OR) of 7.6 (CI 5.2-11.2, p<0.001) for abnormal fertilization compared with Group MII. The blastocyst formation rate was directly associated with oocyte maturation, at 36.4% for MII, 11.4% for MI-MII and 0.6% for MI. Conclusion: Oocytes collected at the MI stage after OCH that did not mature to MII after rescue maturation had a blastocyst formation rate of only 0.6%, while those in MII and MI-MII had rates of 36.4% and 11.4%, respectively. However, we found a pregnancy with the birth of a healthy baby from a blastocyst formed after intracytoplasmic sperm injection (ICSI) of an MI oocyte.

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Section: Discussionmentioning

confidence: 99%

The usefulness of metaphase I oocytes in women who undergo controlled ovarian hyperstimulation for intracytoplasmic sperm injection

Bilibio

Lorenzzoni

Meireles

et al. 2020

JBRA Assisted Reproduction

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“…Os resultados obtidos revelaram uma taxa de gravidez evolutiva por ciclo iniciado de 6,7%, por TE 25,0% e por doente 20,0%, o que está de acordo com o descrito na literatura. 2,27 Trata-se de um grupo de mulheres com respostas desfavoráveis em tratamentos prévios, cuja única alternativa seria a doação de ovócitos. A técnica de PMA mais utilizada neste trabalho foi a ICSI, o que está de acordo com a literatura, que refere que no contexto de protocolos de estimulação ovárica mínima associados a um número baixo de ovócitos, a ICSI está associada a maiores taxas de fecundação.…”

Section: Discussionunclassified

“…Alves MC, et al Procriação medicamente assistida em ciclo natural, Acta Med Port 2019 Jan;32(1): [25][26][27][28][29] e analisados com recurso à estatística descritiva…”

Section: Methodsunclassified

Procriação Medicamente Assistida em Ciclo Natural: Avaliação dos Resultados de um Departamento de Medicina da Reprodução

Alves¹,

Marques

Leite

et al. 2019

Acta Med Port

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Introduction: Medically assisted reproduction in natural cycle has been investigated, especially in women with poor response to conventional ovarian stimulation, with endometrial receptivity improvement, lower cost and possibility of successive cycles. The disadvantages are: lower profitability per treatment cycle and higher cancellation rate. The aim of this study was to determine the rate of clinical pregnancy in infertile women subjected to medically assisted reproduction in natural cycle.Material and Methods: Retrospective study of 149 medically assisted reproduction without ovarian stimulation of 50 infertile women, between January/2011 and October/2014.Results: The mean age of women undergoing medically assisted reproduction in natural cycle was 36.1 years. Approximately half (46.0%) of the cycles were performed in poor responders. On the day of ovulation trigger, the mean diameter of the follicle was 17.5 mm. Twenty-three cycles (15.4%) were canceled prior to ovulation trigger. In 8 cycles (5.3%), ovulation occurred between ovulation trigger and oocyte retrieval. In the majority of cycles (n = 118; 79.2%) oocyte retrieval was executed, a medically assisted reproduction technique was performed in 71 (47.6%), mostly intracytoplasmic injection. The overall fertilization rate was 77.5%. In 40 cycles (26.8%) there was embryo transfer. The implantation rate and the clinical pregnancy rate by embryo transfer was 35.0% and 25.0%, respectively. Most pregnancies occurred in poor responders, according to Bologna criteria.Discussion: Although the pregnancy rate per cycle started was 6.7%, the rate of clinical pregnancy per embryo transfer is quite satisfactory, being a group of women with unfavorable responses in previous treatments. The relatively high rates of cycle cancellation are mitigated by the greater simplicity and lower cost of these cycles.Conclusion: The results obtained in this study demonstrate that Medically Assisted Reproduction in natural cycle may be an alternative treatment for ovarian stimulation in patients with poor prognosis, whose only alternative would be oocyte donation.

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“…Natural progesterone plays a role in oocyte maturity and embryo development [ 16 ]. Although immature oocytes can be normally fertilized, the developmental capability of the resultant embryo is reduced, compared to embryos resulting from mature oocytes [ 17 ]. Also, synthetic progestins create a poor environment for the development of the implanted embryo by suppressing endometrial maturation.…”

Section: Discussionmentioning

confidence: 99%

Occurrence of anembryonic pregnancy with use of levonorgestrel subdermal implant (JADELLE®): a case report

Moutchia-Suh

Mouemba

Ngwasiri³

2018

J Med Case Reports

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BackgroundProgestin-only subdermal implants are one of the most effective contraceptive methods. Anembryonic pregnancy is not reported as a possible outcome in cases of contraceptive failure of these products. We present a rare case of anembryonic pregnancy occurring in a woman with levonorgestrel-releasing implant (JADELLE®).Case presentationA 31-year-old Cameroonian (black African) housewife with a JADELLE® implant for 13 months, consulted at our hospital for a 1-month history of pelvic pain, prolonged menstrual bleeding, and spotting. She had a last normal menstrual period 8 weeks 1 day prior to presentation. On examination, there was suprapubic tenderness and blood trickling from her cervix. Despite a negative qualitative urine pregnancy test, an empty intrauterine gestational sac with mean sac diameter of 28 mm was visualized on pelvic ultrasound. Dilation and curettage with suction was done and she had complete relief from symptoms.ConclusionThis case report highlights the possibility of anembryonic pregnancy occurring in women using the levonorgestrel-releasing subdermal implant (JADELLE®).

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Fertilization, embryo development, and clinical outcome of immature oocytes obtained from natural cycle in vitro fertilization

Cited by 12 publications

References 18 publications

The usefulness of metaphase I oocytes in women who undergo controlled ovarian hyperstimulation for intracytoplasmic sperm injection

The usefulness of metaphase I oocytes in women who undergo controlled ovarian hyperstimulation for intracytoplasmic sperm injection

Procriação Medicamente Assistida em Ciclo Natural: Avaliação dos Resultados de um Departamento de Medicina da Reprodução

Occurrence of anembryonic pregnancy with use of levonorgestrel subdermal implant (JADELLE®): a case report

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