Laboratory aids to diagnosis—enzymes

Schwartz, Morton K.

doi:10.1002/1097-0142(197601)37:1+<542::aid-cncr2820370719>3.0.co;2-g

Cited by 58 publications

(7 citation statements)

References 33 publications

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“…The molecule stimulates directly the ability of tumor cells to produce lung metastatic nodules [47,48]. Clinically AMF/PGI expression examined by IHC [33][34][35] as well as enzymatic activity in serum [49] has been shown to be associated well with metastatic progression in malignant tumors. It is interesting that hypoxia-induced metastasis is dependent on AMF/PHI activity in pancreatic carcinoma [46].…”

Section: Discussionmentioning

confidence: 99%

Prognostic significance of 18F-FDG uptake in primary osteosarcoma after but not before chemotherapy: a possible association with autocrine motility factor/phosphoglucose isomerase expression

Sato

Yanagawa

Dobashi³

et al. 2008

Clin Exp Metastasis

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Response to neoadjuvant chemotherapy is a significant prognostic factor for osteosarcoma (OS). 18-F-fluorodeoxy-D: -glucose (FDG) positron emission tomography (PET) is a noninvasive imaging modality that correlates with histological grading in musculoskeletal sarcomas. To determine the prognostic value of FDG PET in patients receiving chemotherapy, 13 patients were evaluated by FDG-PET, and followed for more than 4 years. FDG PET standardized uptake values before (SUV1) and after (SUV2) chemotherapy were analyzed and correlated with the expression of metastasis-related glycolytic enzyme, autocrine motility factor (AMF)/phosphoglucose isomerase (PGI) by immunohistochemical examination in surgically excised tumors. Although mean SUV1 for OS patients with metastatic lesions were similar to those in the completely disease-free (CDF) group (6.5 vs. 6.6, respectively, P = 0.975), mean SUV2 for OS with metastatic lesions were significantly higher than those in the CDF group (5.1 vs. 2.5, respectively, P = 0.0445). Interestingly, immunohistochemical analysis using anti-AMF/PGI antibody revealed that SUV2 correlated significantly with the AMF/PGI staining titers (P = 0.0303), while no correlation between SUV1 and the AMF/PGI staining titers existed (P = 0.964). The present study suggests that FDG PET after chemotherapy may provide information for AMF/PGI-related metastatic potentiality of residual tumors located out side of the area surgically resected afterward, and then lead to a useful prediction of the patients' prognosis.

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Section: Discussionmentioning

confidence: 99%

Prognostic significance of 18F-FDG uptake in primary osteosarcoma after but not before chemotherapy: a possible association with autocrine motility factor/phosphoglucose isomerase expression

Sato

Yanagawa

Dobashi³

et al. 2008

Clin Exp Metastasis

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“…However, this test alone has certain limitations, since CEA may not be elevated in primary tumours, especially Dukes A and B lesions, or when there is a minimal residual tumour load remaining after resection of the primary tumour. The probable site of the metastases is not indicated by the level of CEA, although this omission can be overcome, at least in part, by the synchronous measurement of serum enzymes that reflect disturbances of hepatic function (Cooper et al, 1975;Munjal et al, 1976;Schwartz, 1976) but these tests do not become positive until there is a considerable tumour load, as judged by inspection of the liver at laparotomy (Cooper et al, 1976a). In a search for other biochemical tests that might be used to form an array for the monitoring of colorectal cancer, our attention has turned to the a globulins.…”

mentioning

confidence: 99%

Acute-phase reactant protein profiles: an aid to monitoring large bowel cancer by CEA and serum enzymes

Ward¹,

Cooper²,

Turner³

et al. 1977

Br J Cancer

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Summary.-The profiles of 4 acute-phase reactant proteins (APRPs) (haptoglobin (HPT)-, a, antitrypsin (AAT), al acid glycoprotein (AGP) and prealbumin (PALB)) have been studied during the evolution of bowel cancer. Serial measurements of these APRPs can add to the information obtained from measurements of the level of CEA and hepatic enzymes during the monitoring of postoperative patients. There is considerable stability in the profile in a given individual in health. Rises of AAT and AGP are associated with metastases. High levels of HPT may suggest involvement of the bowel wall by recurrent cancer. PALB levels tend to reflect the nutritional status. A discriminant function based on the log CEA, AAT and AGP preoperative blood levels can considerably improve on the predictive value attained using CEA levels alone.

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“…In addition to the serum PAP there are several other tests that have been used in an attempt to aid in the clinical evaluation and staging of patients with prostatic cancer. Serum alkaline phosphatase frequently is elevated markedly in patients with osteoblastic metastases [57]. The bone isoenzyme of serum alkaline phosphatase appears to be more specific, particularly in the presence of liver disease.…”

Section: Other Tumor Markersmentioning

confidence: 97%

Overview of past and current philosophy of prostatic cancer

1980

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Carcinoma of the prostate is the second most common cancer in men, yet no significant change in overall survival has occurred since the original description of the results of castration by Huggins and Hodges. Many important questions about the disease remain unanswered. The cause of prostatic cancer is unknown, and few specific environmental or viral agents have been linked with the tumor. Increased recognition of the importance of frequent digitial rectal examination has resulted in more tumors being diagnosed in early stages. Developments in sonography suggest that it may be useful in detecting the presence of prostatic cancer and whether extraprostatic extension has occurred. Recent inprovements in the sensitivity of prostatic acid phosphatase assays have been made, but their use as a screening tool remains limited. In patients with clinical stage B lesions that are microscopically confined to the prostate, treatment by radical prostatectomy appears to confer greatest survival. The exact role of radiotherapy remains to be defined. However, when the tumor extends beyond the prostate and is localized to the pelvis, external beam ro interstitial radiation is appropriate. Pelvic lymphadenectomy has significant morbidity, but less invasive methods of pelvic nodal evaluation are less accurate. Lymphadenectomy has not been shown to have any therapeutic effect. Whether hormonal therapy improves survival needs further investigation, and efforts must continue to develop means of predicting hormonal responsiveness. Those patients unlikely to respond to hormonal therapy should be treated with early chemotherapy.

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Laboratory aids to diagnosis—enzymes

Cited by 58 publications

References 33 publications

Prognostic significance of 18F-FDG uptake in primary osteosarcoma after but not before chemotherapy: a possible association with autocrine motility factor/phosphoglucose isomerase expression

Prognostic significance of 18F-FDG uptake in primary osteosarcoma after but not before chemotherapy: a possible association with autocrine motility factor/phosphoglucose isomerase expression

Acute-phase reactant protein profiles: an aid to monitoring large bowel cancer by CEA and serum enzymes

Overview of past and current philosophy of prostatic cancer

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