Label-free sensitive detection of influenza virus using PZT discs with a synthetic sialylglycopolymer receptor layer

Erofeev, Alexander; Gorelkin, Petr; Колесов, Д. В.; Kiselev, G. A.; Dubrovin, Evgeniy V.; Yaminsky, I.

doi:10.1098/rsos.190255

Cited by 22 publications

(16 citation statements)

References 44 publications

(74 reference statements)

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“…Results was analysed by monitoring resonance frequency shift of the disc radial mode with a detection limit of concentrations below 105 virus particles per millilitre. This study reported that Piezo transducers with sialylglycopolymer sensor layers have a long lifetime, a high sensitivity and the possibility of reproducible results [96].…”

Section: Piezoelectric Biosensormentioning

confidence: 92%

Detection methods for influenza A H1N1 virus with special reference to biosensors: a review

et al. 2020

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H1N1 (Swine flu) is caused by influenza A virus, which is a member of Orthomyxoviridae family. Transmission of H1N1 occurs from human to human through air or sometimes from pigs to humans. The influenza virus has different RNA segments, which can reassert to make new virus strain with the possibility to create an outbreak in unimmunized people. Gene reassortment is a process through which new strains are emerging in pigs, as it has specific receptors for both human influenza and avian influenza viruses. H1N1 binds specifically with an α-2,6 glycosidic bond, which is present in human respiratory tract cells as well as in pigs. Considering the fact of fast multiplication of viruses inside the living cells, rapid detection methods need an hour. Currently, WHO recommended methods for the detection of swine flu include real-time PCR in specific testing centres that take 3–4 h. More recently, a number of methods such as Antigen–Antibody or RT-LAMP and DNA biosensors have also been developed that are rapid and more sensitive. This review describes the various challenges in the diagnosis of H1N1, and merits and demerits of conventional vis-à-vis latest methods with special emphasis on biosensors.

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Section: Piezoelectric Biosensormentioning

confidence: 92%

Detection methods for influenza A H1N1 virus with special reference to biosensors: a review

et al. 2020

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“…This was the first detection at aM range (140 aM for H5N1 and 14 fM for H1N1) using an impedimetric glycan biosensor. A similar approach was used by Erofeev and Gorelkin [141 , 142] , a syalylglycopolymer constituted of an H5N3 glycoprotein modified-polyacrylamide. The striking difference is the detection methodologies.…”

Section: Viral Respiratory Biosensorsmentioning

confidence: 99%

Biosensors for the detection of respiratory viruses: A review

Cordeiro²,

et al. 2020

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Highlights A review containing the newest contributions of biosensors for respiratory viruses’ detection is presented. Influenza virus, coronavirus and respiratory syncytial virus were extensively analyzed. Tables containing biosensors information regarding the detection of the viruses are presented. Discussion based on the new trends and authors accomplishments are applied. SARS-CoV-2 biosensors already published were included and analyzed.

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“…A detection limit as low as 1 ng mL −1 was obtained for influenza A H1N1 HA antigen at room temperature. Erofeev et al [84] described label-free rapid detection of influenza A virus using Ag-coated lead zirconate titanate (PZT) piezoelectric disks of Surface acoustic wave (SAW) sensor for influenza A virus detection. a) Preparation of bioactive surfaces for SAW sensors; b) photograph of a SAW sensor mounted onto a fixture with low-loss microwave probes; c) photomicroscopy image of the microwave probes in contact with the electrodes; and d) phase change versus time for a SAW sensor exposed to H1N1 HA antigen solutions of various concentrations and phosphate-buffered saline (PBS).…”

Section: Influenza a Virus: Group Vmentioning

confidence: 99%

“…Erofeev et al. [ 84 ] described label‐free rapid detection of influenza A virus using Ag‐coated lead zirconate titanate (PZT) piezoelectric disks of 100 µm thickness. The disks, modified with synthetic sialylglycopolymers based on a polymer matrix, which biospecifically bind the haemagglutinin proteins on the influenza viruses, were inserted in a flowing virus suspension.…”

Section: Piezoelectric Biosensorsmentioning

confidence: 99%

A Review of Piezoelectric and Magnetostrictive Biosensor Materials for Detection of COVID‐19 and Other Viruses

et al. 2020

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fever with or without chills, chest tightness, dry cough, and shortness of breath, while developing patchy to diffuse infiltration of the lungs, as shown radiographically in Figure 1. Identifying and monitoring SARS-CoV-2 infection has become crucially important. A recent projection of the transmission dynamics of SARS-CoV-2 [2] showed that longitudinal serological studies are desperately needed to determine the extent and duration of immunity to SARS-CoV-2. Even in the event of apparent elimination, maintenance of SARS-CoV-2 surveillance is still needed because of a possible resurgence of contagion. In the past, notable viruses have emerged suddenly from obscurity or anonymity, provoking concern from the point of view of immunology regarding their sustained epidemic transmission in naive human populations. More than 70% of these infections have been zoonotic, entering either directly from wild animal reservoirs or indirectly via an intermediate domestic animal host. [3] Ebola virus, avian influenza, human immunodeficiency virus (HIV), and SARS are all examples of zoonoses that have emerged from wild animals, presenting an increasingly serious threat to human health and economies worldwide. Figure 2 shows the trend in the number of people infected with SARS-CoV-2. [4] The spread of the severe acute respiratory syndrome coronavirus has changed the lives of people around the world with a huge impact on economies and societies. The development of wearable sensors that can continuously monitor the environment for viruses may become an important research area. Here, the state of the art of research on biosensor materials for virus detection is reviewed. A general description of the principles for virus detection is included, along with a critique of the experimental work dedicated to various virus sensors, and a summary of their detection limitations. The piezoelectric sensors used for the detection of human papilloma, vaccinia, dengue, Ebola, influenza A, human immunodeficiency, and hepatitis B viruses are examined in the first section; then the second part deals with magnetostrictive sensors for the detection of bacterial spores, proteins, and classical swine fever. In addition, progress related to early detection of COVID-19 (coronavirus disease 2019) is discussed in the final section, where remaining challenges in the field are also identified. It is believed that this review will guide material researchers in their future work of developing smart biosensors, which can further improve detection sensitivity in monitoring currently known and future virus threats.

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Label-free sensitive detection of influenza virus using PZT discs with a synthetic sialylglycopolymer receptor layer

Cited by 22 publications

References 44 publications

Detection methods for influenza A H1N1 virus with special reference to biosensors: a review

Detection methods for influenza A H1N1 virus with special reference to biosensors: a review

Biosensors for the detection of respiratory viruses: A review

A Review of Piezoelectric and Magnetostrictive Biosensor Materials for Detection of COVID‐19 and Other Viruses

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