Label-free optical resonant sensors for biochemical applications

Ciminelli, Caterina; Dell’Olio, Francesco; Campanella, Carlo Edoardo; Armenise, Mario Nicola

doi:10.1016/j.pquantelec.2013.02.001

Cited by 181 publications

(112 citation statements)

References 270 publications

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“…More recently, after the substantial development in telecommunications, organic materials based resonators have received intensive attention in metrology and sensing environmental applications, biology, medical and healthcare diagnostics, food quality control and security. Such photonics sensors relying on resonators have become the subject of comprehensive research with sizeable developments of enhanced sensing platforms devoted to the label-free detection of a wide variety of chemical and biochemical [14][15][16][17][18], biological agents and biomedical materials [19][20][21][22][23][24][25][26][27][28].…”

Section: Introductionmentioning

confidence: 99%

Polymer resonators sensors for detection of sphingolipid gel/fluid phase transition and melting temperature measurement

Víe

Lhermite

et al. 2017

Sensors and Actuators A: Physical

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This work describes a low-cost biophotonic sensor shaped by way of cheap processes as hybrid silicon/silica/polymer resonators able to detect biological molecule gel/fluid phase transition as lipids at very low concentration (sphingomyelin). The photonic structure is composed of specific amplified deep UV photoresist-polymer waveguides coupled by a sub-wavelength gap with racetrack microresonators allowing a low temperature-dependent operation ranging from 16 to 42 °C. The temperature dependent wavelength shift and the thermo-optic coefficient characterizing the quantified resonances and opto-geometric properties of the device have been evaluated, highlighting an enough low thermal features of the whole system for such application. With an appropriate vesicle lipid deposition process specific in biology associated to an apt experimental bio-thermo-photonic protocol (made of serial optical resonance spectra acquisitions with statistical treatments), the dynamic evolution of the sphingomyelin lipid phase transition was assessed: then, the ability to detect their own gel/fluid transition phase and melting temperature has been demonstrated with a mass product factor 10 7 lower than that of more conventional methods. The equilibrium of the regime of the resonators was highlighted as being broken by the dynamic of the sphingomyelin and its own phase transition prior relevant detection.

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Section: Introductionmentioning

confidence: 99%

Polymer resonators sensors for detection of sphingolipid gel/fluid phase transition and melting temperature measurement

Víe

Lhermite

et al. 2017

Sensors and Actuators A: Physical

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“…Especially integrated-optical (IO) sensors are more and more commercialized (e.g., Genalyte, Optisense, PLCD, Farfield Sensors) [5], mainly because of their high intrinsic sensitivity [6] in combination with the possibilities they offer for integration in optofluidic devices [7]. Many different types of IO sensors have been described in the literature such as grating coupler devices, silicon wires, photonic crystals, waveguide interferometers and microring resonators (MRRs) [6,8,9]. Application of these sensors offers important advantages such as the prospect of label-free detection, the possibility of real-time measurement (bio-specific interaction analysis), immunity to electromagnetic interference, and the high potential for integration with other (micro) components.…”

Section: Introductionmentioning

confidence: 99%

Performance of Arrayed Microring Resonator Sensors with the TriPleX Platform

GAJ¹,

RG²

2016

J Biosens Bioelectron

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Integrated-optical (bio) chemical sensors are more and more commercialized, mainly because of their high intrinsic sensitivity in combination with the possibilities they offer for integration in optofluidic devices. The microring resonator (MRR), for example, is a very feasible structure to be used as microarray sensor element for multiplex biosensing. Fabrication of MRRs has been described in the case of the TriPleX platform employing well-defined stacks of stoichiometric Si 3 N 4 and SiO 2 material. This platform allows for a wide variety of applications, due to its intrinsic low loss and its transparency for the VIS/NIR wavelength range. In the present paper, we describe the recent achievements in the characterization of arrays of these MRRs regarding temperature sensitivity, refractive index sensitivity and protein immobilization performance. Furthermore, the use of a reference channel/reference MRR is demonstrated in order to show the advantage of compensation of unintended change in temperature or sample composition. The refractive index sensitivity was determined to be 104 nm/RIU and the limit of detection was about 2 × 10 -6 RIU. MRRs appeared to behave very comparable (expressed as the coefficient of (intra-array) variation (CV)) regarding the response to temperature (CV≈0.3%) as well as refractive index (CV<0.1%). Furthermore, it is shown that protein immobilization onto the different MRRs of the same arrays can be realized in a comparable way (CV<3%). A good comparability (i.e., a low variation) in these aspects allows for the use of internal referencing in order to compensate for unintended change in temperature or refractive index and also helps to attain a high assay precision in the ultimate biosensing application. Ongoing research is focused on the integration of more functionality on chip and further miniaturization in order to allow for fabrication of complex, though affordable, sensor devices.

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“…This can be avoided in the case of using integrated optical sensors. Integrated optical sensors are very attractive due to their advantages of high sensitivity, ultra-wide bandwidth, low detection limit, compactness, and immunity to electromagnetic interference [2,3].…”

Section: Introductionmentioning

confidence: 99%

“…This leads to a large footprint area and low sensitivity. For example, recent results showed that the sensitivities of 108 nm/RIU [2,12] and 200 nm/RIU [13] for glucose and ethanol detection using single microring resonator can be achieved. In addition, by using microfluidics with grating, ethanol sensor with a sensitivity of 50 nm/RIU can be obtained [14].…”

Section: Introductionmentioning

confidence: 99%

Two-channel highly sensitive sensors based on 4 × 4 multimode interference couplers

Thanh

2017

Photonic Sens

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Abstract:We propose a new kind of microring resonators (MRR) based on 4 × 4 multimode interference (MMI) couplers for multichannel and highly sensitive chemical and biological sensors. The proposed sensor structure has advantages of compactness and high sensitivity compared with the reported sensing structures. By using the transfer matrix method (TMM) and numerical simulations, the designs of the sensor based on silicon waveguides are optimized and demonstrated in detail. We apply our structure to detect glucose and ethanol concentrations simultaneously. A high sensitivity of 9000 nm/RIU, detection limit of 2 × 10 -4 for glucose sensing and sensitivity of 6000 nm/RIU, detection limit of 1.3 × 10 -5 for ethanol sensing are achieved.

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Label-free optical resonant sensors for biochemical applications

Cited by 181 publications

References 270 publications

Polymer resonators sensors for detection of sphingolipid gel/fluid phase transition and melting temperature measurement

Polymer resonators sensors for detection of sphingolipid gel/fluid phase transition and melting temperature measurement

Performance of Arrayed Microring Resonator Sensors with the TriPleX Platform

Two-channel highly sensitive sensors based on 4 × 4 multimode interference couplers

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