“…It is obvious that a label-free method for DNA hybridization detection would make the above steps obsolete, making the process simple, rapid and low cost. Many techniques have been developed for label-free DNA hybridization detection, including electrochemical detection (Xiao et al, 2007;Shiigi et al, 2005;Riccardi et al, 2008), impedance detection (Berdat et al, 2008), electrochemiluminescence detection (Wei et al, 2007), surface plasmon resonance method (Kim et al, 2007), and colorimetry (Li and Rothberg, 2004b). Though these methods avoid the labeling protocols, most of the detection systems still make use of solidphase interface DNA hybridization and are heterogeneous methods (Xiao et al, 2007;Shiigi et al, 2005;Fabris et al, 2007).…”