Label-free carbon quantum dots as photoluminescence probes for ultrasensitive detection of glucose

Qiao, Shi Zhang; Li, Haitao; Li, Hao; Liu, Juan; Kong, Weiqian; Hu, Qiaozhen; Huang, Hui; Yang, Liu

doi:10.1039/c5ra12829c

Cited by 13 publications

(3 citation statements)

References 34 publications

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“…It is well-known that glucose oxidase (GOX)-catalyzed glucose oxidation reactions can consume oxygen 36 – 38 (Fig. 1a ).…”

Section: Introductionmentioning

confidence: 99%

Enzymatic enhancing of triplet–triplet annihilation upconversion by breaking oxygen quenching for background-free biological sensing

Huang

et al. 2021

Nat Commun

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Triplet-triplet annihilation upconversion nanoparticles have attracted considerable interest due to their promises in organic chemistry, solar energy harvesting and several biological applications. However, triplet-triplet annihilation upconversion in aqueous solutions is challenging due to sensitivity to oxygen, hindering its biological applications under ambient atmosphere. Herein, we report a simple enzymatic strategy to overcome oxygen-induced triplet-triplet annihilation upconversion quenching. This strategy stems from a glucose oxidase catalyzed glucose oxidation reaction, which enables rapid oxygen depletion to turn on upconversion in the aqueous solution. Furthermore, self-standing upconversion biological sensors of such nanoparticles are developed to detect glucose and measure the activity of enzymes related to glucose metabolism in a highly specific, sensitive and background-free manner. This study not only overcomes the key roadblock for applications of triplet-triplet annihilation upconversion nanoparticles in aqueous solutions, it also establishes the proof-of-concept to develop triplet-triplet annihilation upconversion nanoparticles as background free self-standing biological sensors.

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“…It is well-known that glucose oxidase (GOX)-catalyzed glucose oxidation reactions can consume oxygen 36 – 38 (Fig. 1a ).…”

Section: Introductionmentioning

confidence: 99%

Enzymatic enhancing of triplet–triplet annihilation upconversion by breaking oxygen quenching for background-free biological sensing

Huang

et al. 2021

Nat Commun

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“…Electron‐transfer properties of CDs were used for glucose sensing, based on monochromatic fluorescence turn‐on/turn‐off mode. [ 84 ] Moreover, Cho and Park developed a ratiometric fluorescence glucose biosensor by combining two fluorescence fluorophores (CDs and rhodamine 6G) to induce color changes during glucose detection (Figure 8D ). [ 71 ] Fluorescence color change was realized by fluorescence quenching, due to bienzymatic reactions of glucose oxidase (GOx) and horseradish peroxidase (HRP) with glucose.…”

Section: Nanomaterials For Diabetes Diagnosismentioning

confidence: 99%

Emerging Theranostic Nanomaterials in Diabetes and Its Complications

Liu

Zeng

et al. 2021

Advanced Science

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Diabetes mellitus (DM) refers to a group of metabolic disorders that are characterized by hyperglycemia. Oral subcutaneously administered antidiabetic drugs such as insulin, glipalamide, and metformin can temporarily balance blood sugar levels, however, long‐term administration of these therapies is associated with undesirable side effects on the kidney and liver. In addition, due to overproduction of reactive oxygen species and hyperglycemia‐induced macrovascular system damage, diabetics have an increased risk of complications. Fortunately, recent advances in nanomaterials have provided new opportunities for diabetes therapy and diagnosis. This review provides a panoramic overview of the current nanomaterials for the detection of diabetic biomarkers and diabetes treatment. Apart from diabetic sensing mechanisms and antidiabetic activities, the applications of these bioengineered nanoparticles for preventing several diabetic complications are elucidated. This review provides an overall perspective in this field, including current challenges and future trends, which may be helpful in informing the development of novel nanomaterials with new functions and properties for diabetes diagnosis and therapy.

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“…Heteroatom‐doped carbon quantum dots offer versatile platforms for specific detection of the bioactive molecules. Glucose is widespread in animal body to provide energy source, and thus its detection based on B‐doped carbon quantum dots was established by combining the quenching effect of hydrogen peroxide and the enzymatic reaction of glucose oxidase ,. Covalent binding of boronic acid‐modified carbon quantum dots with glucose is another popular detection method for glucose .…”

Section: Chemosensing Based On Functional Carbon Quantum Dotsmentioning

confidence: 99%

Functional Carbon Quantum Dots: A Versatile Platform for Chemosensing and Biosensing

Feng

Qian

2017

The Chemical Record

131

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Carbon quantum dot has emerged as a new promising fluorescent nanomaterial due to its excellent optical properties, outstanding biocompatibility and accessible fabrication methods, and has shown huge application perspective in a variety of areas, especially in chemosensing and biosensing applications. In this personal account, we give a brief overview of carbon quantum dots from its origin and preparation methods, present some advance on fluorescence origin of carbon quantum dots, and focus on development of chemosensors and biosensors based on functional carbon quantum dots. Comprehensive advances on functional carbon quantum dots as a versatile platform for sensing from our group are included and summarized as well as some typical examples from the other groups. The biosensing applications of functional carbon quantum dots are highlighted from selective assays of enzyme activity to fluorescent identification of cancer cells and bacteria.

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Label-free carbon quantum dots as photoluminescence probes for ultrasensitive detection of glucose

Abstract: Carbon quantum dots were demonstrated to be easy-to-use photoluminescence probes for the detection of glucose with fluorescence enhancement.

Cited by 13 publications

References 34 publications

Enzymatic enhancing of triplet–triplet annihilation upconversion by breaking oxygen quenching for background-free biological sensing

Enzymatic enhancing of triplet–triplet annihilation upconversion by breaking oxygen quenching for background-free biological sensing

Emerging Theranostic Nanomaterials in Diabetes and Its Complications

Functional Carbon Quantum Dots: A Versatile Platform for Chemosensing and Biosensing

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