Label-free and highly selective MOFs-based dopamine detection in urine of Parkinson’s patients

Xie, Wenyue; Yin, Yanying; Gu, Ruoheng; Xu, Jingyue; Su, Xing; Wang, Yan; Liu, Ruina; Liu, Xiaozhi; Huang, Jianyong

doi:10.1016/j.cej.2022.136371

Cited by 24 publications

(10 citation statements)

References 54 publications

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“…As a result, trace DA concentrations were successfully detected from actual urine samples from three healthy volunteers despite 100-fold dilution (Table S4). The tested values are calculated to be 1224, 1714, and 1584 nM based on the established linear relationship (Figure f), and these testing results are within the normal DA levels (424–2612 nM/24 h) of healthy individuals . Afterward, the detection accuracy for this fluorescence method was also verified by the standard addition method, and satisfactory recovery values from 94.0 to 100.4% have been obtained (Table S4).…”

Section: Resultsmentioning

confidence: 99%

“…The tested values are calculated to be 1224, 1714, and 1584 nM based on the established linear relationship (Figure 4f), and these testing results are within the normal DA levels (424−2612 nM/24 h) of healthy individuals. 11 Afterward, the detection accuracy for this fluorescence method was also verified by the standard addition method, and satisfactory recovery values from 94.0 to 100.4% have been obtained (Table S4). In addition, artificial urine samples have also been prepared and spiked with different concentrations of DA in order to simulate the urinary DA secretion of varying individuals.…”

Section: ■ Introductionmentioning

confidence: 99%

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Tailoring Efficient Fluorogenic Tactic for Ultrasensitive Detection of Dopamine in Urine and Rat Brain through Real-Time and In Situ Formation of High-Performance Fluorophore

Xu,

He,

Luo

et al. 2023

Anal. Chem.

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Owing to the predominance of dopamine (DA) in controlling mental health, planning an innovative method for DA detection with simplicity and high efficacy is conducive to the assessment of neurological disorders. Herein, an efficient fluorogenic tactic has been elaborated for ultrasensitive detection of DA with remarkably enhanced turn-on response. Utilizing a twisted intramolecular charge-transfer (TICT)-suppressing strategy, a highly emissive azocine derivative 11-hydroxy-2,3,6,7,11,12,13,14-octahydro-1H,5H,10H-11,14a-methanoazocino[5′,4′:4,5]furo[2,3-f]pyrido[3,2,1-ij]quinolin-10-one (J-Aza) is generated via a one-step reaction between DA and 8-hydroxyjulolidine. It is marvelous that J-Aza not only possesses ideal fluorescence quantum yield (ΦF) as high as 0.956 but also exhibits bathochromic shifted fluorescence (green emissive) and stronger anti-photobleaching capacity superior to traditional azocine-derived 1,2,3,4-tetrahydro-5H-4,11a-methanobenzofuro[2,3-d]azocin-5-one (Aza) with moderate ΦF, blue fluorescence, and poor photostability. By confining the TICT process, the detection limit to DA can be reduced to 80 pM, which is competitive in contrast to previously reported fluorescence methods. Encouraged by the instant response (within 90 s), wide linear range (0.1–500 nM), great selectivity, and excellent sensitivity, this fluorogenic method has been used for the real-time measurement of DA contents in practical urine samples with satisfactory results. Furthermore, the cerebral DA level in the reserpine-induced depression rat model has also been evaluated by our designed method, demonstrating its potent analytical applicability in the biosensing field.

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Section: Resultsmentioning

confidence: 99%

Section: ■ Introductionmentioning

confidence: 99%

Tailoring Efficient Fluorogenic Tactic for Ultrasensitive Detection of Dopamine in Urine and Rat Brain through Real-Time and In Situ Formation of High-Performance Fluorophore

Xu,

He,

Luo

et al. 2023

Anal. Chem.

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“…Significantly lower levels of DA content are found in the urine of people with PD than that of healthy people (424-2612 nmol/24 h). [100] Nevertheless, DA detection in real clinical samples is still challenging. Hence, the design and fabrication of biosensors with improved sensitivity and high selectivity to quantify ultralow levels of DA are vital in diagnosis of PD.…”

Section: Mofs In Biosensing Of Parkinson's Diseasementioning

confidence: 99%

Metal–Organic Frameworks‐Based Nanoplatforms for the Theranostic Applications of Neurological Diseases

Niu

Zhao

et al. 2023

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Neurological diseases are the foremost cause of disability and the second leading cause of death worldwide. Owing to the special microenvironment of neural tissues and biological characteristics of neural cells, a considerable number of neurological disorders are currently incurable. In the past few years, the development of nanoplatforms based on metal–organic frameworks (MOFs) has broadened opportunities for offering sensitive diagnosis/monitoring and effective therapy of neurology‐related diseases. In this article, the obstacles for neurotherapeutics, including delayed diagnosis and misdiagnosis, the existence of blood brain barrier (BBB), off‐target treatment, irrepressible inflammatory storm/oxidative stress, and irreversible nerve cell death are summarized. Correspondingly, MOFs‐based diagnostic/monitoring strategies such as neuroimaging and biosensors (electrochemistry, fluorometry, colorimetry, electrochemiluminescence, etc.) and MOFs‐based therapeutic strategies including higher BBB permeability, targeting specific lesion sites, attenuation of neuroinflammation/oxidative stress as well as regeneration of nerve cells, are extensively highlighted for the management of neurological diseases. Finally, the challenges of the present research from perspective of clinical translation are discussed, hoping to facilitate interdisciplinary studies at the intersections between MOFs‐based nanoplatforms and neurotheranostics.

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“…Nanofluids are thought to provide significant benefits over traditional heat transfer fluids. The thermal characteristics of host fluids can be considerably enhanced by a very small amount of guest nanoparticles when they are evenly dispersed and suspended in base fluids [18]. Several researchers have suggested different physical ideas, and procedures, and created new models for enhancing the transport features in an attempt to understand unexpected discoveries and so get beyond the constraints of classical models.…”

Section: Proceedings Of the 8 Th International Exchange And Innovatio...mentioning

confidence: 99%

Heat Transfer Analysis of Al_2O_3 Nanoparticles

Ali¹,

Afzal²,

Javaid³

et al. 2022

Proceedings of International Exchange and Innovation Conference on Engineering &Amp; Sciences (IEICES)

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The capability of temperature variation is essential for cooling industrial operations like transportation such as car and heavy vehicle radiators, electronics devices, petroleum industrial systems, etc. Different methods and fluids are used in the cooling process in industrial systems. The basic fluids are based on temperature, thermal stability, and the effectiveness of heat transmission. Thermal characteristics improve when nanoparticles are added to the basic fluid. Using Al2O3 nanofluid the heat transfer and variation in the temperature at the entrance side and outlet side of the microchannel pipe were studied. Through ANSYS Fluent, a well-defined method for utilizing Al2O3 nanofluids to investigate the impact of various performance optimization factors of nanofluids was performed. The temperature of the nanofluids at the inlet and outlet is found 300 K and 313.7 K, respectively during the simulation. The pressure drops from the inlet side to the outlet side as well a result that raising the temperature, heat coefficient, thermal conductivity, and viscosity of the base fluids when Al2O3 nanoparticles are added.

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Label-free and highly selective MOFs-based dopamine detection in urine of Parkinson’s patients

Cited by 24 publications

References 54 publications

Tailoring Efficient Fluorogenic Tactic for Ultrasensitive Detection of Dopamine in Urine and Rat Brain through Real-Time and In Situ Formation of High-Performance Fluorophore

Tailoring Efficient Fluorogenic Tactic for Ultrasensitive Detection of Dopamine in Urine and Rat Brain through Real-Time and In Situ Formation of High-Performance Fluorophore

Metal–Organic Frameworks‐Based Nanoplatforms for the Theranostic Applications of Neurological Diseases

Heat Transfer Analysis of Al_2O_3 Nanoparticles

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