Lab-on-a-chip technologies for food safety, processing, and packaging applications: a review

Sridhar, Adithya; Kapoor, Ashish; Kumar, Ponnusamy Senthil; Ponnuchamy, Muthamilselvi; Balasubramanian, Sivasamy; Vo, Dai‐Viet N.

doi:10.1007/s10311-021-01342-4

Cited by 28 publications

(8 citation statements)

References 180 publications

(173 reference statements)

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“…Moreover, the established methods using glass substrates would also enable glass-to-polydimethylsiloxane (PDMS) bonding suitable for the implementation of microfluidic chips. [53,54] On the other side, the presented self-assembly of the spider silk protein and modified variants thereof enable employing mild aqueous conditions. The formation of corresponding fibrillar networks has been shown to leave unchanged tertiary structures of fused protein modifications or secondary structures of coupled nucleic acids.…”

Section: Discussionmentioning

confidence: 99%

Dual Patterning of Self‐Assembling Spider Silk Protein Nanofibrillar Networks

Lamberger

Kocourková

Minařík

et al. 2022

Adv Materials Inter

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well as cell-cell and cell-ligand interactions. [10,11] Due to their reduced size and compact construction, these require fewer resources for their production, reducing their costs, whilst also minimizing the amount of analyte. This enables a much higher throughput of samples and their readouts than with more conventional macroscopic methods. [10,12] Photolithography represents a commonly used approach for microstructuring, whereby substrates are covered by a photosensitive resin, onto which illumination with a specific pattern imparts spatially defined soluble/insoluble areas, thus enabling selective deprotection of the surface and subsequent modifications at microscales. [10,13] Nonetheless, such microstructuring is often limited to the usage of covalently coupled synthetic polymers, due to the relatively harsh conditions involved in the photoresist processing.Milder methods have been developed, such as polymer grafting using photocatalyzed coupling reactions, [14,15] but 3D structuring and additional functionalization of the networks require ever more complex polymers increasing associated synthesis costs. The polymerization of dopamine could also be used to generate a pattern with high fidelity, which can be further modified, [16,17] but the spectrum of reactions that can be employed, is limited to the dopamine moiety, requiring elaborate chemistry if desiring to spatiotemporally implement several different functions.An approach to multilayering different functional substrates is presented by self-assembling protein films, which adhere to the prior layer using non-covalent interactions. [18] Such approaches are more versatile in the functionality and modification alternatives, but the introduction of specific functions on different spots of the substrate is often problematic. The non-covalent bonding, which predominates among the film layers, must also be resilient to breaking, limiting the variety of available interactions dependent on the application conditions, and impeding the development of a generally applicable system.A strong non-covalent bonding interaction is found in silks, where the intrinsically random coil domains self-assemble into β-sheet-rich formations, whereby they are stabilized in a network of the same proteins. [19] The difference in solubility and the inducible nature of the conversion could be used for micropatterning. [20][21][22][23][24] Yet, a method, which provides the duality of being able to introduce high fidelity, high-resolution micropattern with a plethora of possible functionalization Self-assembly of a recombinant spider silk protein into nanofibrillar networks in combination with photolithography is used to produce diversely functionalized micropattern. Amino-modified substrates coated with a positive tone photoresist are processed into 1 µm deep arbitrarily shaped microwells, at the bottom of which spider silk proteins are covalently coupled to the deprotected aminated surface. The protein layer serves to seed the self-assembly of nanofibrils from the same protein in the ...

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Section: Discussionmentioning

confidence: 99%

Dual Patterning of Self‐Assembling Spider Silk Protein Nanofibrillar Networks

Lamberger

Kocourková

Minařík

et al. 2022

Adv Materials Inter

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“…The wordlist food safety and food analysis formed the theme food technology, and Cluster III (blue color) consists of 115 published articles. Additionally, the wordlist of genetic engineering formed the theme of Cluster IV (yellow color), comprised of 100 published items; and, lastly, pathology formed the theme of Cluster V (purple color), comprised of 115 published items [ 154 ].…”

Section: Mir Established Lab-on-a-chipmentioning

confidence: 99%

Advanced Waveguide Based LOC Biosensors: A Minireview

Kanjwal¹,

Ghaferi²

2022

Sensors

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This mini review features contemporary advances in mid-infrared (MIR) thin-film waveguide technology and on-chip photonics, promoting high-performance biosensing platforms. Supported by recent developments in MIR thin-film waveguides, it is expected that label-free assimilated MIR sensing platforms will soon supplement the current sensing technologies for biomedical diagnostics. The state-of-the-art shows that various types of waveguide material can be utilized for waveguide spectroscopic measurements in MIR. However, there are challenges to integrating these waveguide platforms with microfluidic/Lab-on-a-Chip (LOC) devices, due to poor light–material interactions. Graphene and its analogs have found many applications in microfluidic-based LOC devices, to address to this issue. Graphene-based materials possess a high conductivity, a large surface-to-volume ratio, a smaller and tunable bandgap, and allow easier sample loading; which is essential for acquiring precise electrochemical information. This work discusses advanced waveguide materials, their advantages, and disease diagnostics with MIR thin-film based waveguides. The incorporation of graphene into waveguides improves the light–graphene interaction, and photonic devices greatly benefit from graphene’s strong field-controlled optical response.

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“…The creation and uptake of portable, easy-to-use, analysis tools is democratizing science, enabling expensive, often inaccessible, laboratory-based testing to be performed with slashed costs, improved convenience, and with less required operator knowledge 1 . Among options such as paper-based diagnostics 2 , wearable sensors 3 , and other lab-on-a-chip devices 4 , smartphone-based platforms are intriguing due to the ubiquity of phone ownership worldwide, including in remote and resource-limited areas. Their already in-built electronics and computational capabilities also offer the potential for more objective, quantitative measurements and comparisons than may be possible with other systems such as, for example, common paper-based test strips.…”

Section: Introductionmentioning

confidence: 99%

Quantitative, high-sensitivity measurement of liquid analytes using a smartphone compass

Ferris,

Zabow

2024

Nat Commun

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Smartphone ubiquity has led to rapid developments in portable diagnostics. While successful, such platforms are predominantly optics-based, using the smartphone camera as the sensing interface. By contrast, magnetics-based modalities exploiting the smartphone compass (magnetometer) remain unexplored, despite inherent advantages in optically opaque, scattering or auto-fluorescing samples. Here we report smartphone analyte sensing utilizing the built-in magnetometer for signal transduction via analyte-responsive magnetic-hydrogel composites. As these hydrogels dilate in response to targeted stimuli, they displace attached magnetic material relative to the phone’s magnetometer. Using a bilayer hydrogel geometry to amplify this motion allows for sensitive, optics-free, quantitative liquid-based analyte measurements that require neither any electronics nor power beyond that contained within the smartphone itself. We demonstrate this concept with glucose-specific and pH-responsive hydrogels, including glucose detection down to single-digit micromolar concentrations with potential for extension to nanomolar sensitivities. The platform is adaptable to numerous measurands, opening a path towards portable, inexpensive sensing of multiple analytes or biomarkers of interest.

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Lab-on-a-chip technologies for food safety, processing, and packaging applications: a review

Cited by 28 publications

References 180 publications

Dual Patterning of Self‐Assembling Spider Silk Protein Nanofibrillar Networks

Dual Patterning of Self‐Assembling Spider Silk Protein Nanofibrillar Networks

Advanced Waveguide Based LOC Biosensors: A Minireview

Quantitative, high-sensitivity measurement of liquid analytes using a smartphone compass

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