La survie en hémodialyse chronique au Cameroun

Fouda, Hermine; Ashuntantang, Gloria; Kaze, François Folefack; Halle, Marie-Patrice

doi:10.11604/pamj.2017.26.97.9658

Cited by 15 publications

(12 citation statements)

References 11 publications

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“…Heart failure was associated with high interdialytic weight gain (IDWG) [ 26 ] and hyperkalemia was frequent in HD patients before the second HD session [ 27 ]. Also, mortality of patients on maintenance HD in Cameroon is high ranging from 26.6% to 57.58% with some of the principal causes being uremia and catheter-related sepsis [ 28 , 29 ]. Despite the importance of adherence to dialysis regimen, data are inexistent in our setting.…”

Section: Introductionmentioning

confidence: 99%

Non-adherence to hemodialysis regimens among patients on maintenance hemodialysis in sub-Saharan Africa: an example from Cameroon

et al. 2020

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Background Non-adherence (NA) to hemodialysis regimens is one of the contributors to the high morbidity and mortality observed in patients with end-stage kidney disease (ESKD). We aimed to determine the prevalence and predictors of NA to hemodialysis (HD) regimens among patients on maintenance HD in Cameroon. Methods A cross-sectional study in two HD centers in Cameroon was conducted from January to February 2016. Consenting patients on HD for ≥3 months were included. NA to fluid restriction was defined as a mean interdialytic weight gain (IDWG) in the past month >5.7% of the dry weight, NA to dietary restriction as a pre dialysis serum phosphorus >5.5 mg/dl in a patient on phosphate binders and who is well-nourished, and NA to HD sessions as skipping at least one session in the past month. The study was approved by the institutional ethics board. Results A total of 170 (112 males) participants with a median age of 49 years (range 14–79) were included. The median dialysis vintage was 35 months (range 3–180 months). The prevalence of NA was 15.3% to fluid restriction, 26.9% to dietary restriction, and 21.2% to dialysis sessions. Age ≤49 years ( p = .006, OR: 5.07, 95% CI: 1.59–16.20) and unmarried status ( p = .041, OR: 2.63, 95% CI: 1.04–6.66) were independently associated with NA to fluid restrictions. No factor was associated with NA to dietary restrictions and HD sessions. Conclusions NA to HD regimens is common amongst patients in Cameroon. Younger age and being unmarried were the predictors of NA to fluid restriction.

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Section: Introductionmentioning

confidence: 99%

Non-adherence to hemodialysis regimens among patients on maintenance hemodialysis in sub-Saharan Africa: an example from Cameroon

et al. 2020

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“…In Cameroon, about 8 to 10.8% of the haemodialysis population is HIV positive [ 20 , 21 ]. Outcomes of patients on maintenance haemodialysis in Cameroon remain very poor [ 22 , 23 ]. The impact of HIV positivity on patient outcomes on maintenance haemodialysis is unknown.…”

Section: Introductionmentioning

confidence: 99%

Survival of HIV infected patients on maintenance hemodialysis in Cameroon: a comparative study

et al. 2018

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BackgroundThere are conflicting reports on the impact of HIV in the era of combined antiretroviral (c-ART) on survival of patient with ESKD. We aimed to compare the one-year survival of HIV positive patients to that of their HIV negative counterparts with ESKD on maintenance haemodialysis in Cameroon.MethodsThis was a retrospective cohort study conducted in the haemodialysis units of the Douala and Yaoundé General Hospitals. All HIV positive patients treated by maintenance haemodialysis between January 2007 and March 2015 were included. A comparative group of HIV negative patients with ESKD were matched for age, sex, co morbidities, year of dialysis initiation and haemodialysis unit. Relevant data at the time of haemodialysis initiation and during the first year of haemodialysis was noted. Survival was analysed using the Kaplan Meier and Cox regression hazard ratio estimator. A p value < 0.05 was considered statistically significant.ResultsA total of 57 patients with HIV and 57 without HIV were included. Mean age was 46.25 ± 11.41 years, and 52.6% were females in both groups. HIV nephropathy (50.9%) was the main presumed aetiology of ESKD in the HIV group, while chronic glomerulonephritis (33.3%) and diabetes (21.1%) were the main aetiologies in the HIV negative group. At initiation of dialysis, the median CD4 count was 212 cell/mm3 (IQR; 138–455) and 77.2% were receiving c-ART. The proportion of patients who initiated dialysis with a temporary venous catheter was similar in both groups (p = 0.06). After one year on haemodialysis, survival rate was lower in the HIV positive group compared to the HIV negative group (61.4%/78.9%, HR: 2.05; 95% CI: 1.03–4.08; p = 0.042).Kaplan Meier survival curve was in direction of a lower survival in HIV positive group (p = 0.052).ConclusionThe one year survival of HIV positive patients on maintenance haemodialysis in Cameroon seems to be lower compared to their HIV negative counterparts.

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“…In 2010, out of the 2.6 million people projected worldwide who accessed renal replacement therapy (RRT), only about 7% were from low-income and lower-middle income countries [ 3 , 4 ]. In Cameroon, the morbidity and mortality of CKD is high, especially amongst patients on haemodialysis [ 5 – 7 ]. Emphasis should therefore be on prevention, early detection and managing factors of progression of CKD, in order to curb incidence of ESRD, while improving access to RRT in SSA [ 3 , 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Determinants of hyperuricemia in non-dialysed chronic kidney disease patients in three hospitals in Cameroon

et al. 2018

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BackgroundChronic kidney disease (CKD) poses a substantial health burden in sub-Saharan Africa, with risk factors ranging from communicable to non-communicable diseases. Hyperuricemia has been recently identified as a factor of progression of CKD. Identifying factors associated with hyperuricemia in CKD patients would help determine interventions to reduce CKD mortality, particularly in resources limited countries. We sought to determine the prevalence and factors associated with hyperuricemia in non-dialysed CKD adult patients in Cameroon.MethodsThis was a cross-sectional study of non-dialysed CKD patients, conducted in 3 referral nephrology units in Cameroon. Relevant clinical and laboratory data were collected using interviewer-administered questionnaires. Serum uric acid, spot urine protein and spot urine creatinine were assessed. Associations between variables were assessed using multivariate analysis. Level of statistical significance was set at α < 0.05.ResultsA sample of 103 participants was included. Mean age of study participants was 55.78 ± 12.58 years, and 59.3% were men. Sixty-nine (67%) had hyperuricemia. Patient’s age (OR: 1.08, 95% CI: 1.03–1.13), estimated glomerular filtration rate (OR: 0.94, 95% CI: 0.90–0.98), spot urine protein-creatinine ratio (OR: 1.83, 95% CI: 1.07–3.12), no hypertension (OR: 0.09, 95% CI: 0.02–0.46), urate lowering therapy (OR: 4.99, 95% CI: 1.54–16.16), loop diuretics (OR: 3.39, 95% CI: 1.01–11.42), obesity (OR: 6.12, 95% CI: 1.15–32.55) and no anaemia (OR: 0.04, 95% CI: 0.00–0.29) were independently significantly associated with hyperuricemia.ConclusionsIn this sample of non-dialysed CKD patients in Cameroon, about 7 out of 10 had hyperuricemia. Hyperuricemia was independently associated with patient’s age, estimated glomerular filtration rate, spot urine protein-creatinine ratio, hypertension, urate lowering therapy, loop diuretics, obesity and anaemia. More studies are required to establish causal relationships between these associations.

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La survie en hémodialyse chronique au Cameroun

Cited by 15 publications

References 11 publications

Non-adherence to hemodialysis regimens among patients on maintenance hemodialysis in sub-Saharan Africa: an example from Cameroon

Non-adherence to hemodialysis regimens among patients on maintenance hemodialysis in sub-Saharan Africa: an example from Cameroon

Survival of HIV infected patients on maintenance hemodialysis in Cameroon: a comparative study

Determinants of hyperuricemia in non-dialysed chronic kidney disease patients in three hospitals in Cameroon

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