La3+/Sr2+ Dual-Substituted Hydroxyapatite Nanoparticles as Bone Substitutes: Synthesis, Characterization, In Vitro Bioactivity and Cytocompatibility

Sundarabharathi, Lakshmanaperumal; Chinnaswamy, Mahendran; Ponnamma, Deepalekshmi; Parangusan, Hemalatha; Al‐Maadeed, Mariam Al Ali

doi:10.1166/jnn.2020.18577

Cited by 10 publications

(2 citation statements)

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“…There is no divergence of human normal physiological functions even in injured bone by replacing artificial bone implant techniques. The bone implant is reflecting the need for treatment for the normal functioning of joints and also ensures the treatment superiority [7][8][9]. Now, numerous biomaterials are developed for bone renovation applications such as bioceramics, biometals, and biopolymers [10].…”

Section: Introductionmentioning

confidence: 99%

[Retracted] AZ63/Ti/Zr Nanocomposite for Bone‐Related Biomedical Applications

Sathish¹,

Saravanan²,

Shreepad

et al. 2023

BioMed Research International

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Considering the unique properties of magnesium and its alloy, it has a vast demand in biomedical applications, particularly the implant material in tissue engineering due to its biodegradability. But the fixing spares must hold such implants till the end of the biodegradation of implant material. The composite technology will offer the added benefits of altering the material properties to match the requirements of the desired applications. Hence, this experimental investigation is aimed at developing a composite material for manufacturing fixing spares like a screw for implants in biomedical applications. The matrix of AZ63 magnesium alloy is reinforced with nanoparticles of zirconium (Zr) and titanium (Ti) through the stir casting-type synthesis method. The samples were prepared with equal contributions of zirconium (Zr) and titanium (Ti) nanoparticles in the total reinforcement percentage (3%, 6%, 9%, and 12%). The corrosive and tribological studies were done. In the corrosive study, the process parameters like NaCl concentration, pH value, and exposure time were varied at three levels. In the wear study, the applied Load, speed of sliding, and the distance of the slide were considered at four levels. Taguchi analysis was employed in this investigation to optimize the reinforcement and independent factors to minimize the wear and corrosive losses. The minimum wear rate was achieved in the 12% reinforced sample with the input factor levels of 60 N of load on the pin, 1 m/s of disc speed at a sliding distance was 1500 m, and the 12% reinforce samples also recorded a minimum corrosive rate of 0.0076 mm/year at the operating environment of 5% NaCl-concentrated solution with the pH value of 9 for 24 hrs of exposure. The prediction model was developed based on the experimental results.

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Section: Introductionmentioning

confidence: 99%

[Retracted] AZ63/Ti/Zr Nanocomposite for Bone‐Related Biomedical Applications

Sathish¹,

Saravanan²,

Shreepad

et al. 2023

BioMed Research International

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“…This is explained by the rapid heat up of the particles after irradiation, reaching a solution temperature of 50.9 °C that can denature the proteins from the bacterial membrane [ 36 ]. As better activity against S. aureus and P. aeruginosa has been reported for La 3+ /Sr 2+ HAp NPs [ 138 ], further studies could be performed to incorporate the co-doped NPs into the same or other systems for PPT.…”

Section: Biomedical Applications Of Lanthanides-substituted Hapmentioning

confidence: 99%

Lanthanides-Substituted Hydroxyapatite for Biomedical Applications

Lama-Odría

Valle

Puiggalı́

2023

IJMS

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Lately, there has been an increasing demand for materials that could improve tissue regenerative therapies and provide antimicrobial effects. Similarly, there is a growing need to develop or modify biomaterials for the diagnosis and treatment of different pathologies. In this scenario, hydroxyapatite (HAp) appears as a bioceramic with extended functionalities. Nevertheless, there are certain disadvantages related to the mechanical properties and lack of antimicrobial capacity. To circumvent them, the doping of HAp with a variety of cationic ions is emerging as a good alterative due to the different biological roles of each ion. Among many elements, lanthanides are understudied despite their great potential in the biomedical field. For this reason, the present review focuses on the biological benefits of lanthanides and how their incorporation into HAp can alter its morphology and physical properties. A comprehensive section of the applications of lanthanides-substituted HAp nanoparticles (HAp NPs) is presented to unveil the potential biomedical uses of these systems. Finally, the need to study the tolerable and non-toxic percentages of substitution with these elements is highlighted.

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