La sensibilité des œufs de la drosophile (Drosophila melanogaster, Meig) á l'action létale des rayons ultraviolets

Ghelelovitch, S

doi:10.1016/0027-5107(68)90085-7

Cited by 6 publications

(3 citation statements)

References 19 publications

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“…This suggests that to the left of dp there is a tumour enhancer of tu-48a expression in the original tumour stock, or a tumour suppressor in the all chromosome. The data imply that tu-48a is located between pr (54-4) and px (100-5), which is not consistent with the earlier mapping of this mutant (Ghelelovitch, 1958). The reason for this disparity is not apparent.…”

Section: Results (I) Allelism Of Melanotic Tumour Genescontrasting

confidence: 79%

“…Recently Grell used three marker genes and mapped tu bw at 80-5 (Lindsley & Grell, 1968). The tu-48a gene has been mapped at 29-5 on the second chromosome (Ghelelovitch, 1958). The tu-W and tu-g genes have not been mapped, though the evidence (Wilson, et al 1955) suggests that tumorigenesis in the tu-W strain may be due to the presence of two secondchromosome tumour mutants.…”

Section: Results (I) Allelism Of Melanotic Tumour Genesmentioning

confidence: 99%

“…Melanotic tumour genes show incomplete penetrance and variable expressivity, and many strains also carry enhancing or suppressing modifier genes (Herskowitz & Burdette, 1951;Wilson, King & Lowry, 1955;Glass, 1957;Ghelelovitch, 1958;Burdette, 1959;Burnet & Sang, 1964;Barigozzi, 1968). Consequently, conventional techniques of localization and analysis have to be modified.…”

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confidence: 99%

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The genetics of some second chromosome melanotic tumour mutants ofDrosophila melanogaster

Sparrow

1974

Genet. Res.

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SummaryThe genetic relationships of the available second chromosome melanotic tumour mutants in Drosophila melanogaster have been investigated. Complementation tests demonstrate the existence of new alleles of the tu bw locus and show that tu-W and tu-g are alleles. The data suggest that there is a minimum of three major gene loci on the second chromosome involved in tumorigenesis. A number of modifier genes were found which affect the penetrance of the major tumour genes analysed. These and the problems they cause in mapping the low penetrant tumour genes are discussed. It has not been possible to map tu-48a, tu- W and tu-g accurately, due largely to the presence of modifier genes. It appears that the genetic basis for melanotic tumour formation is complex.

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Section: Results (I) Allelism Of Melanotic Tumour Genescontrasting

confidence: 79%

Section: Results (I) Allelism Of Melanotic Tumour Genesmentioning

confidence: 99%

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confidence: 99%

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