La Section Totale de la Moelle Dorsale

Lhermitte, Jean

doi:10.1097/00005053-192201000-00047

Cited by 14 publications

(8 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Such stimulation at the upper lumbar cord level (near L1–L2) was found to trigger stepping-like movements in completely SCI patients lying in a bed. These observations, combined with those from earlier reports (often anecdotal ones) of spontaneous rhythmic movements in the legs of patients with chronic SCI (Holmes, 1915; Lhermitte, 1919; Kuhn, 1950; Bussel et al, 1988, 1992), provide altogether compelling evidence for the existence of a CPG for locomotion in humans.…”

Section: Cpg For Locomotion In Humanssupporting

confidence: 54%

Central Pattern Generator for Locomotion: Anatomical, Physiological, and Pathophysiological Considerations

Guertin¹

2013

Front. Neur.

178

142

View full text Add to dashboard Cite

This article provides a perspective on major innovations over the past century in research on the spinal cord and, specifically, on specialized spinal circuits involved in the control of rhythmic locomotor pattern generation and modulation. Pioneers such as Charles Sherrington and Thomas Graham Brown have conducted experiments in the early twentieth century that changed our views of the neural control of locomotion. Their seminal work supported subsequently by several decades of evidence has led to the conclusion that walking, flying, and swimming are largely controlled by a network of spinal neurons generally referred to as the central pattern generator (CPG) for locomotion. It has been subsequently demonstrated across all vertebrate species examined, from lampreys to humans, that this CPG is capable, under some conditions, to self-produce, even in absence of descending or peripheral inputs, basic rhythmic, and coordinated locomotor movements. Recent evidence suggests, in turn, that plasticity changes of some CPG elements may contribute to the development of specific pathophysiological conditions associated with impaired locomotion or spontaneous locomotor-like movements. This article constitutes a comprehensive review summarizing key findings on the CPG as well as on its potential role in Restless Leg Syndrome, Periodic Leg Movement, and Alternating Leg Muscle Activation. Special attention will be paid to the role of the CPG in a recently identified, and uniquely different neurological disorder, called the Uner Tan Syndrome.

show abstract

Section: Cpg For Locomotion In Humanssupporting

confidence: 54%

Central Pattern Generator for Locomotion: Anatomical, Physiological, and Pathophysiological Considerations

Guertin¹

2013

Front. Neur.

178

142

View full text Add to dashboard Cite

show abstract

“…Early descriptions of rhythmic involuntary movements gener ated by the spinal cord lacking supraspinal input, date back from the work of Lhermite (1919) [57] and Kuhn (1950) [58]. The latter author even claimed that a patient with completely transected spinal cord could produce 'self-propagating' stepping movements at times.…”

Section: 12 Rhythmic Movements and Contractions In Sc I Patientsmentioning

confidence: 99%

Neural control of locomotion; Part 1: The central pattern generator from cats to humans

1998

View full text Add to dashboard Cite

In the last years it has become possible to regain some locomotor activity in patients suffering from an incomplete spinal cord injury (SCI) through intense training on a treadmill. The ideas behind this approach owe much to insights derived from animal studies. Many studies showed that cats with complete spinal cord transection can recover locomotor function. These observations were at the basis of the concept of the central pattern generator (CPG) located at spinal level. The evidence for such a spinal CPG in cats and primates (including man) is reviewed in part 1, with special emphasis on some very recent developments which support the view that there is a human spinal CPG for locomotion.

show abstract

“…Traumatic lesions o f the spinal cord as the cause of spinal myoclonus were described by Lhermitte (1919) and later on by Patrikios (1938). Sigwald et al (1955) reported about a 52-year-old woman who suffered from rhyth mical myoclonus in the neck, the shoulder girdle, and the arms following a trauma of the spinal cord.…”

Section: Discussionmentioning

confidence: 99%

Spinal Myoclonus

Nohl¹,

Doose²,

Gross-Selbeck³

et al. 1978

Eur Neurol

View full text Add to dashboard Cite

A 5-year-old boy is reported with spinal myoclonus caused by cervical astrocytoma due to neurofibromatosis. The essential clinical and electromyographical signs of spinal myoclonus are the following: (1) Continuous rhythmical appearance in muscles innervated by the affected segments of the spinal cord. (2) Synchronous myoclonus in muscles innervated by the same spinal segments of one body side, asynchronous myoclonus in muscles of different segments as well as in contralateral muscles of the same segments. (3) Usually stable frequency, which may increase to a manifold under the influence of different stimuli. (4) Accentuation of the myoclonus under mental distress, disappearance during deeper sleep. The pathophysiological basis of spinal myoclonus might be a disinhibition in the area of the spinal formatio reticularis. Supraspinal stimuli can influence the myoclonus.

show abstract

La Section Totale de la Moelle Dorsale

Cited by 14 publications

References 0 publications

Central Pattern Generator for Locomotion: Anatomical, Physiological, and Pathophysiological Considerations

Central Pattern Generator for Locomotion: Anatomical, Physiological, and Pathophysiological Considerations

Neural control of locomotion; Part 1: The central pattern generator from cats to humans

Spinal Myoclonus

Contact Info

Product

Resources

About