Spinal Myoclonus

Nohl, M.; Doose, H.; Gross-Selbeck, G.; Jensen, H.-P.

doi:10.1159/000114935

Cited by 13 publications

(5 citation statements)

References 10 publications

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“…1,19 Nevertheless, a spinal myoclonus influenced by sensory stimuli but disappearing during the sleep is described in children. 3 In our case, the absence of myoclonus during the sleep would suggest that the physiological inhibition on the motor function during the sleep was not damaged by the spinal tumor.…”

Section: Discussionmentioning

confidence: 54%

“…This hypothesis could also explain the persistence of the myoclonus after the tumor surgical excision, found in the present cases as well as by other authors. 3,4 Actually, the tumor growth might induce a permanent alteration of the central generator, thus making the tumor removal ineffective on the myoclonus outcome, independently from the extension of the surgical resection.…”

Section: Discussionmentioning

confidence: 99%

“…1 Spinal cord tumors represent an unusual cause of spinal myoclonus, being sporadically reported in adults and/or mainly before the computed tomography (CT) or magnetic resonance imaging (MRI) era. 2,3 In children, such an association is very uncommon and limited to thoracic astrocytomas. 4 We report on the ''exceptional'' case of a child harboring a cervical ganglioglioma presenting with segmental spinal myoclonus (SSM).…”

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confidence: 99%

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Segmental Spinal Myoclonus and Metastatic Cervical Ganglioglioma: An Unusual Association

et al. 2009

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Segmental spinal myoclonus rarely occurs in association with spinal cord tumor. Only 3 cases have been reported in children so far, mainly concerning astrocytomas of the thoracic spinal cord. We report on a 2-year-old boy suffering from segmental spinal myoclonus involving the upper limbs and harboring a cervical tumor. The clinical and electrophysiological features ruled out a myoclonus of different origin (cortical, subcortical, propriospinal) other than other types of movement disorders. Neuroimaging and histological examinations showed the exceptional presence of a ganglioglioma as the cause of the segmental spinal myoclonus. The clinical and electrophysiological characteristics as well as the possible etiopathogenesis and differential diagnosis are discussed on the basis of the pertinent literature to add some more information about the unusual association between spinal cord tumors and spinal myoclonus.

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Section: Discussionmentioning

confidence: 54%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Segmental Spinal Myoclonus and Metastatic Cervical Ganglioglioma: An Unusual Association

et al. 2009

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“…It is intriguing that pain was a preceding or accompanying symptom in our case as well as in the other cases with peripherally induced hyperkinesias (20)(21)(22)26,27). At present we know that at the beginning of such movement disorders tremor is a frequent symptom, at least in the cases with sympathetic reflex dystrophy (5).…”

Section: Discussionmentioning

confidence: 68%

Bilateral myoclonus of the trapezius muscles after distal lesion of an accessory nerve

et al. 1996

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Observations of rhythmic or semirhythmic myoclonus due to a peripheral nerve lesion are exceptional. We report on a patient with thorax trauma with multiple bilateral hematomas of the paravertebral musculature. Eight years later he developed rhythmic myoclonus of both trapezius muscles and thoracic pain. Infiltration of a paramedially located scar at the level of D5-6 with a local anesthetic agent led to an intermittent relief of the myoclonus as did anesthetic blockade of the left accessory nerve. Surgical excision of the scar, which contained multiple dystrophic axons on histological examination, cured the patient's symptoms as illustrated in a videotape. This indicates that peripheral afferents contributed to the myoclonus. Ephaptic transmission, ectopic excitation, or misdirected neuronal sprouting secondary to the trauma are possible peripheral mechanisms responsible for the movement disorder. Successful blockade of the left accessory nerve with bilateral relief of the symptoms suggests a secondary, more centrally located mechanism, e.g., in the brain stem, probably driven by an altered afferent input. It is concluded that rhythmic or semirhythmic and focal myoclonus need a careful workup to look for a peripheral cause because such a condition would be accessible for surgical treatment.

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“…Segmental myoclonus was described as being caused by spinal tumor, viral myelitis, ischemic myelopathy or trauma [1][2][3][4][5][6][7][8][9][10][11][12][13][14], Radiation myelopathy was not observed to be the cause of segmental myoclonus despite its high incidence of 2.9% [15][16][17][18]. The common symptoms of radiation myelopathy described in the literature are Lhermitte's sign, motor sensory and sphincter lesions combined in various clinical syndromes [15][16][17][18], A sim ilar observation of continuous wake-sleep segmental myoclonus selectively inhibited by REM sleep and veri fied polysomnographically (PSG) was not found in the literature consulted and for this reason it is presented here [19][20][21][22],…”

Section: Introductionmentioning

confidence: 99%

Postradiation Segmental Myoclonus Selectively Inhibited by REM Sleep (Sleep-Wake Myoclonus)

Askenasy

Brunet²,

Léger³

et al. 1988

Eur Neurol

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A 46-year-old male patient was irradiated following left orchiectomy for seminoma. Three months after radiation, segmental myoclonus appeared involving all skeletal muscle groups up to the level of D10, the area of radiation. Urodynamic testing showed the presence of segmental myoclonus in the urethral sphincter. An around-the-clock ‘continuous segmental myoclonus’ during sleep and wakefulness with a frequency of 1 c/s and an amplitude of 400 µV selectively inhibited by REM sleep was not found in the literature. This continuous segmental myoclonus caused by a radiation myelopathy at D10-D11 was followed up for 2 years. It was partially controlled by carbama-zepine.

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Spinal Myoclonus

Cited by 13 publications

References 10 publications

Segmental Spinal Myoclonus and Metastatic Cervical Ganglioglioma: An Unusual Association

Segmental Spinal Myoclonus and Metastatic Cervical Ganglioglioma: An Unusual Association

Bilateral myoclonus of the trapezius muscles after distal lesion of an accessory nerve

Postradiation Segmental Myoclonus Selectively Inhibited by REM Sleep (Sleep-Wake Myoclonus)

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