La prueba de la marcha de 6 minutos como factor pronóstico y de capacidad de ejercicio en pacientes con silicosis

Pérez, José Jesús Blanco; Montiel, Victoria Arnalich; Salgado‐Barreira, Ángel; Moure, María Angel Alvarez; Díaz, Adriana Carolina Caldera; Dominguez, Luz Cerdeira; Bello, M. Elena Gonzalez; Villar, Alberto Fernández; Barcala, Francisco Javier González

doi:10.1016/j.arbres.2018.07.004

Cited by 13 publications

(7 citation statements)

References 26 publications

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“… 31 Therefore, it can easily measure the percentage of oxygen in blood by a non- invasive way. The six-minute walk test is safe and reflects the daily living activities more than other tests 32 , 33 Patients were permitted to walk on a flat surface without bearing any weight for six minutes unassisted 34 , 35 so by measuring pulse oximetry andthe six-minute walk test the patient’s functional status can be accurately assessed.…”

Section: Discussionmentioning

confidence: 99%

Effect of Oral Methyl Prednisolone on Different Radiological Patterns of Hypersensitivity Pneumonitis

Tony¹,

Soliman²,

Salem³

2021

JAA

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Background Hypersensitivity pneumonitis (HP) is an immune-mediated disorder that causes inflammation of interstitial lung, bronchioles, and alveoli. Although corticosteroids have been used as first line treatment for HP for many years, it does not provide satisfactory results in all patients. The aim of this study is to compare the effect of oral methylprednisolone on different radiological patterns of HP to identify the most adequate candidates for corticosteroids. Patients and Methods Fifty-three patients with confirmed diagnosis of HP were divided into two groups according to their radiological patterns based on high resolution computed tomography (HRCT) findings. The first group included 21 patients with fibrotic HP (fHP), the second group included 32 patients without fibrosis; non-fibrotic HP patients (nfHP). The second group is divided into 3 subgroups: mosaic, attenuation, centrilobular nodules and finally, ground-glass opacities. All patients were administered methylprednisolone by dose 0.5mg/kg/day for eight consecutive weeks. HRCT was performed at the beginning of the study. Spirometry, six-minute walk and oximetry were performed periodically to assess the patients’ progress. Results Upon finalizing the treatment process, a significant improvement was noticed in FEV1 ( p < 0.001), FVC ( p <0.001), six-minute walk test ( p =0.001) and oximetry ( p <0.05) in nfHP compared to the fHP patients. However, there was a significant improvement in ( p <0.01), FVC ( p <0.01), oximetry ( p <0.01) and six-minute walk test ( p <0.01) in fibrotic patients after receiving the treatment. There was no significant difference in the response of FEV1 ( p =0.82), FVC ( p =0.15), six-minute walk test ( p =0.36) and oximetry ( p =0.27) among the subgroups of nfHP patients. Conclusion It was accordingly concluded that corticosteroid treatment is more effective in treatment of nfHP than fHP patients but still has effect on fibrotic patients. There is no significant difference in the response to corticosteroids among nfHP patients’ subgroups.

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Section: Discussionmentioning

confidence: 99%

Effect of Oral Methyl Prednisolone on Different Radiological Patterns of Hypersensitivity Pneumonitis

Tony¹,

Soliman²,

Salem³

2021

JAA

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“…3,4 Importantly, the distance walked in the 6MWT is strongly associated with prognosis in chronic cardiovascular and respiratory conditions. [5][6][7][8][9][10][11][12] Data on the clinical correlations and prognostic implications of the 6MWT in patients with rheumatoid arthritis (RA) are scarce. To the best of our knowledge, to date, no study has evaluated the factors independently associated with the 6MWT distance in patients with RA nor the prognostic implications of the distance walked.…”

Section: Introductionmentioning

confidence: 99%

6-Minute Walking Test in Rheumatoid Arthritis: Clinical Associations and Prognostic Implications

Ferreira¹,

Saraiva²,

Fonseca³

et al. 2021

Preprint

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Background The clinical associations and prognostic implications of the 6-minute walk test (6MWT) distance in patients with rheumatoid arthritis (RA) is yet to be explored. Aims To identify the clinical features and prognostic implications associated with the 6MWT in patients with RA. Methods Cohort study including 387 RA patients who underwent 6MWT. Regression models (linear and logistic) were built to identify independent predictors of shorter 6MWT distance. Cox proportional models were used to study the association of 6MWT distance with cardiovascular outcomes. Results Patients were subdivided according to 6MWT tertiles: 126 patients walked > 405m, 129 walked 345-405m, and 132 walked < 345m. Older age (> 55 year), elevated waist circumference, NT-pro BNP > 125pg/mL, anemia, C-reactive protein ≥ 3mg/dL, and troponin T ≥ 14pg/mL were independent predictors of walking shorter distances. Patients walking less than 345m had higher risk of a subsequent cardiovascular hospitalisation or cardiovascular death compared with patients walking 345m or more (adjusted HR: 2.98, 95%CI: 1.37–6.51, p = 0.006). Conclusions Older age, abdominal obesity, anemia, cardiac dysfunction, and inflammation were associated with walking shorter distances in patients with RA. Walking less than 345m in the 6MWT was associated with a poor cardiovascular prognosis. The 6MWT is simple, reproducible and inexpensive, easily performed in routine practice, and provides important information regarding the patients´ status and outcomes, enabling the monitorization of the therapeutic optimization of the various domains of the RA.

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“…Exposure to crystalline silica dust occurs in many industries. The occurrence of silicosis results from an imbalance between the penetration of particles and the means of bronchopulmonary purification, as well as the toxicity of silica and the means of repair [1][2][3]. The pathophysiology of this pneumoconiosis involves two phases: a phase of alveolitis after capturing the mineral particles by the alveolar macrophage and a later phase of fibrosis.…”

Section: Introductionmentioning

confidence: 99%

“…In 2012, 166 patients were reported. [3] .In the United States, the annual incidence is reported to be between 36,500 and 37,300 cases, with nearly 2,700 deaths over a decade. [1] In the UK, approximately 600,000 workers were exposed to crystalline silica from 1990 to 1993, about 100 cases were reported each year between 1996 and 2009, and deaths from silicosis decreased from 28 in 1993 to 10 in 2008 [4][5].…”

Section: Introductionmentioning

confidence: 99%

“…[1] In the UK, approximately 600,000 workers were exposed to crystalline silica from 1990 to 1993, about 100 cases were reported each year between 1996 and 2009, and deaths from silicosis decreased from 28 in 1993 to 10 in 2008 [4][5]. China has the most significant number of silicosis patients, with over 500,000 cases recorded between 1991 and 1995, 6,000 new cases, and over 24,000 deaths reported each year [1,3]. Morocco also counts many patients affected by silicosis, especially in Jerada city, where this disease is considered a priority and presents a significant public health issue.…”

Section: Introductionmentioning

confidence: 99%

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The Correlation between Functional Parameters (6-Minute Walk Test) and Life Quality of Silicosis Patients: Case Study in the Jerada City in Morocco

Andaloussi¹,

Senhaji²,

Germain

et al. 2021

Integr J Med Sci

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Introduction: Silicosis is pneumoconiosis secondary to the inhalation of mineral dust containing silica. It represents a real public health problem in the city of Jerada.Purposes: To assess the functional parameters of silicosis patients (based on the 6-minute walk test (6MWT)) and their impact on our patients' quality of life (Saint George's respiratory questionnaire (SGRQ) and hospital anxiety and depression scale (HAD)).Materials and methodology: This is a cross-sectional study of 147 patients with silicosis, designed to collect their socio-demographic data, to assess their respiratory function (6MWT) and their quality of life (SGRQ).Findings: The average age of our patients was 64.08 +/- 6.46 years [46 -81]. At 6MWT, the mean distance walked by our patients is 326.8 +/-168.47 m (30 - 835) or 59% of the predicted distance, with a median of 360m. The mean total Saint George score (SGT) was 68.02 +/- 19.54%. The means of the other Saint George scores were: symptoms (SGS): 45.95 +/- 23.66%, activities (SGA): 79.58 +/- 19.8%, and impact (SGI): 68, Results: The average age of our patients was 64.08 +/- 6.46 years [46 -81]. At 6MWT, the mean distance walked by our patients is 326.8 +/-168.47 m (30 - 835) or 59% of the predicted distance, with a median of 360m. The mean total Saint George score (SGT) was 68.02 +/- 19.54%. The means of the other Saint George scores were: symptoms (SGS): 45.95 +/- 23.66%, activities (SGA): 79.58 +/- 19.8%, and impact (SGI): 68.32 +/- 22.33%. We found a statistically significant relationship between dyspnea, quality of life, anxiety and walking distance.Conclusion: The study demonstrated that silicosis is a pulmonary disease which causes significant functional limitation and deterioration of life quality.

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La prueba de la marcha de 6 minutos como factor pronóstico y de capacidad de ejercicio en pacientes con silicosis

Cited by 13 publications

References 26 publications

Effect of Oral Methyl Prednisolone on Different Radiological Patterns of Hypersensitivity Pneumonitis

Effect of Oral Methyl Prednisolone on Different Radiological Patterns of Hypersensitivity Pneumonitis

6-Minute Walking Test in Rheumatoid Arthritis: Clinical Associations and Prognostic Implications

The Correlation between Functional Parameters (6-Minute Walk Test) and Life Quality of Silicosis Patients: Case Study in the Jerada City in Morocco

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