La(III) complex involving the O,N-donor environment of quinazoline-4(3H)-one Schiff’s base and their antimicrobial attributes against methicillin-resistant Staphylococcus aureus (MRSA)
“…Rare earth metal complexes of Schiff base ligands have been examined owing to their structural diversities, remarkable coordination behavior and broad biological applications [1][2][3][4] . Lanthanides showed remarkable differences in coordination numbers and more flexible coordination geometry when compared to transition metals.…”
In our efforts to propose, Praseodymium (III) metal complex derived from 5-Bromo-2-hydroxybenzyl-2-furyl methyl for the biological efficacy. The structure of the synthesized imine and complex has been characterized by UV, IR, Mass, 1 H and 13 C NMR. The ligand and the metal complex carried for their anti-microbial tendency to control the disease-causing pathogens such as Escherichia coli, Klebsiella pneumonia, Salmonella typhimurium, Acinetobacter baumannii, Pseudomonas aeruginosa and Staphylococcus aureus. The derived metal complex exhibited better result and is additional effective bactericides than the ligand.
“…Rare earth metal complexes of Schiff base ligands have been examined owing to their structural diversities, remarkable coordination behavior and broad biological applications [1][2][3][4] . Lanthanides showed remarkable differences in coordination numbers and more flexible coordination geometry when compared to transition metals.…”
In our efforts to propose, Praseodymium (III) metal complex derived from 5-Bromo-2-hydroxybenzyl-2-furyl methyl for the biological efficacy. The structure of the synthesized imine and complex has been characterized by UV, IR, Mass, 1 H and 13 C NMR. The ligand and the metal complex carried for their anti-microbial tendency to control the disease-causing pathogens such as Escherichia coli, Klebsiella pneumonia, Salmonella typhimurium, Acinetobacter baumannii, Pseudomonas aeruginosa and Staphylococcus aureus. The derived metal complex exhibited better result and is additional effective bactericides than the ligand.
“…La(III) in its stable +3 oxidation state mimics biological ions such as Ca 2+ and K + and hence can be highly beneficial in synthesizing chemical nucleases. [11] La(III) complexes have been used as probes in immunoassays and as MRI agents, [12][13][14] anticancer agents, [15][16][17][18][19] binding agents towards DNA, RNA, proteins and as chemical nucleases, [20][21][22][23][24] antimicrobial agents [25][26][27][28][29][30] as well as antioxidant agents. [31][32] In this view, herein we report the synthesis and characterization of mononuclear as well as hetero-binuclear complexes containing lanthanum(III), copper(II) or nickel(II) ion bridged by versatile ligand N,N′-bis(2-pyridylmethyl)oxamide and ancillary ligand 1,10-phenanthroline which is a classical DNA intercalator.…”
In the present study, hetero-binuclear La(III) complexes were newly synthesized using well known bridging ligand N,N′-bis(2-pyridylmethyl)oxamide (2PMO, 1) and “complexes as ligands” [Cu(2PMO)] (2) and [Ni(2PMO)] (3). The newly synthesized mononuclear (4) as well as hetero-binuclear complexes (5 and 6) were characterized by analytical and spectroscopic techniques. The newly synthesized complexes were tested for their binding ability towards CT-DNA and chemical nuclease property towards SC pUC 19 DNA. The complexes were tested for antibacterial activities against Gram negative bacteria (E. coli and K. pneumonia) and Gram positive bacteria (B. subtilis and S. aureus), antioxidant activities by DPPH radical scavenging and ferrous-ion chelation methods and cytotoxicity against MCF-7 cell lines by MTT assay. The structure-activity relationship revealed that the newly synthesized hetero-binuclear complexes show potent DNA binding and chemical nuclease activities, antibacterial, antioxidant and cytotoxic activities.
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