La fermeture dorsale chez la drosophile. Un modèle génétique de la cicatrisation?

Agnès, François; Noselli, Stéphane

doi:10.1016/s0764-4469(99)80012-2

Cited by 14 publications

(3 citation statements)

References 62 publications

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“…2-B2). These cells are commonly referred to as “medial edge” cells [22], [44], which represent a subpopulation of PE cells that play a crucial role in thorax closure during metamorphosis [21], [22], [31], [45]. Interestingly, α4•PP2A complexes appear to play a major role in the control of cell spreading, migration, and cytoskeletal architecture, presumably via their ability to modulate the activity of the small G-protein Rac [13].…”

Section: Discussionmentioning

confidence: 99%

“…DPP is a morphogen that forms a concentration gradient across imaginal discs, that is essential for cell proliferation and tissue development [30]. Disruption of JNK or DPP signaling usually leads to abnormal patterning and development of the wing disc and consequential thorax and wing defects in the adult fly [29], [31]. A common phenotype seen in JNK and DPP Drosophila mutants is a thorax cleft, but these two pathways play different roles in the maintenance, migration, and fusion of the epithelial sheets [22].…”

Section: Introductionmentioning

confidence: 99%

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Essential Roles of the Tap42-Regulated Protein Phosphatase 2A (PP2A) Family in Wing Imaginal Disc Development of Drosophila melanogaster

et al. 2012

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Protein ser/thr phosphatase 2A family members (PP2A, PP4, and PP6) are implicated in the control of numerous biological processes, but our understanding of the in vivo function and regulation of these enzymes is limited. In this study, we investigated the role of Tap42, a common regulatory subunit for all three PP2A family members, in the development of Drosophila melanogaster wing imaginal discs. RNAi-mediated silencing of Tap42 using the binary Gal4/UAS system and two disc drivers, pnr- and ap-Gal4, not only decreased survival rates but also hampered the development of wing discs, resulting in a remarkable thorax cleft and defective wings in adults. Silencing of Tap42 also altered multiple signaling pathways (HH, JNK and DPP) and triggered apoptosis in wing imaginal discs. The Tap42RNAi-induced defects were the direct result of loss of regulation of Drosophila PP2A family members (MTS, PP4, and PPV), as enforced expression of wild type Tap42, but not a phosphatase binding defective Tap42 mutant, rescued fly survivorship and defects. The experimental platform described herein identifies crucial roles for Tap42•phosphatase complexes in governing imaginal disc and fly development.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Essential Roles of the Tap42-Regulated Protein Phosphatase 2A (PP2A) Family in Wing Imaginal Disc Development of Drosophila melanogaster

et al. 2012

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“…1E and 4D). Scores of mutations lead to failures in dorsal closure (1)(2)(3). This model promises to quantify their phenotypes and elucidate the molecular basis of morphogenesis.…”

mentioning

confidence: 99%

Forces for Morphogenesis Investigated with Laser Microsurgery and Quantitative Modeling

Hutson

Tokutake

Chang

et al. 2003

Science

475

632

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We investigated the forces that connect the genetic program of development to morphogenesis in Drosophila. We focused on dorsal closure, a powerful model system for development and wound healing. We found that the bulk of progress toward closure is driven by contractility in supracellular "purse strings" and in the amnioserosa, whereas adhesion-mediated zipping coordinates the forces produced by the purse strings and is essential only for the end stages. We applied quantitative modeling to show that these forces, generated in distinct cells, are coordinated in space and synchronized in time. Modeling of wild-type and mutant phenotypes is predictive; although closure in myospheroid mutants ultimately fails when the cell sheets rip themselves apart, our analysis indicates that beta(PS) integrin has an earlier, important role in zipping.

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Drosophila as a model of wound healing and tissue regeneration in vertebrates

Belacortu

Paricio

2011

Developmental Dynamics

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Understanding the molecular basis of wound healing and regeneration in vertebrates is one of the main challenges in biology and medicine. This understanding will lead to medical advances allowing accelerated tissue repair after wounding, rebuilding new tissues/organs and restoring homeostasis. Drosophila has emerged as a valuable model for studying these processes because the genetic networks and cytoskeletal machinery involved in epithelial movements occurring during embryonic dorsal closure, larval imaginal disc fusion/regeneration, and epithelial repair are similar to those acting during wound healing and regeneration in vertebrates. Recent studies have also focused on the use of Drosophila adult stem cells to maintain tissue homeostasis. Here, we review how Drosophila has contributed to our understanding of these processes, primarily through live-imaging and genetic tools that are impractical in mammals. Furthermore, we highlight future research areas where this insect may provide novel insights and potential therapeutic strategies for wound healing and regeneration. Developmental Dynamics 240:2379-2404,

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La fermeture dorsale chez la drosophile. Un modèle génétique de la cicatrisation?

Cited by 14 publications

References 62 publications

Essential Roles of the Tap42-Regulated Protein Phosphatase 2A (PP2A) Family in Wing Imaginal Disc Development of Drosophila melanogaster

Essential Roles of the Tap42-Regulated Protein Phosphatase 2A (PP2A) Family in Wing Imaginal Disc Development of Drosophila melanogaster

Forces for Morphogenesis Investigated with Laser Microsurgery and Quantitative Modeling

Drosophila as a model of wound healing and tissue regeneration in vertebrates

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