La démence sénile en France : une estimation de la charge actuelle et projection des tendances futures.

Ritchie, Karen; Robine, Jérémy

doi:10.4267/10608/2685

Cited by 7 publications

(2 citation statements)

References 7 publications

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“…Les mécanismes pathogéniques de la maladie d'Alzheimer s'éclairent de toutes parts. Dans les formes familiales de cette démence dont la prévalence dans la population âgée est si élevée qu'elle pose un grave problème de santé publique [1], on savait que les mutations dans le gène de la préséniline 1 (PS1) favorisaient l'accumulation du peptide β amyloïde mais on n'avait pas la preuve qu'elles intervenaient dans le routage de la protéine APP (m/s n°1, vol. 13, p. 106).…”

Section: Du Nouveau Dans La Maladie D'alzheimerunclassified

Du nouveau dans la maladie d'Alzheimer.

Gilgenkrantz¹

1998

Med Sci (Paris)

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Section: Du Nouveau Dans La Maladie D'alzheimerunclassified

Du nouveau dans la maladie d'Alzheimer.

Gilgenkrantz¹

1998

Med Sci (Paris)

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“…In a Swedish study, 77% of patients with moderate to severe dementia were inpatients (Fratiglioni, 1996). According to Ritchie and Robine (1994), 30–40% of AD patients at all stages are inpatients. Conversely, when looking at inpatients, one finds that the proportion of severely demented patients is quite high, even though it differs according to type of institution and country.…”

Section: Introductionmentioning

confidence: 99%

Clinical features and assessment of severe dementia. A review¹

Boller

Verny

Hugonot‐Diener

et al. 2002

Euro J of Neurology

110

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Sound understanding of the dementia syndrome requires adequate acquaintance with its entire spectrum, from the lightest to the most advanced stages. Most studies of dementia deal with light to moderate stages of the condition, while relatively little attention has been paid to its most severe stages. This review presents a clinical description of patients with severe dementia and of the tests currently available to evaluate their cognitive, behavioural, and functional status. Available instruments such as the Hierarchic Dementia Scale or the Severe Impairment Battery now allow quantification of the cognitive and behavioural status of patients with severe dementia. Experience with severe dementia shows that, far from being in a "vegetative state", as is commonly thought, late-stage patients are in fact quite different from one another and in most cases continue to have an interaction with their environment. This ability to better define the characteristics of patients with severe dementia provides the basis for correlations between clinical data and data derived from neuroimaging, neurochemistry, or neuropathology. It also sets the stage for possible therapeutic trials involving these patients.

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