La cuisine des hommes

Bidaud, Éric

doi:10.3917/lautr.020.0293

Cited by 1 publication

(1 citation statement)

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“…These channels consist of different subunits, although it is the α1 subunit that forms the calcium selective pore (Ertel et al, 2000;Cain and Snutch, 2011). The genes that encode the α1 include CACNA1S, CACNA1C, CACNA1D and CACNA1F for L-types; CACNA1A, CACNA1B and CACNA1E for P/Q-, N-and R-type; and CACNA1G, CACNA1H and CACNA1I for T-types (Bidaud et al, 2006).…”

Section: Voltage-gated Calcium Permeable Ion Channelsmentioning

confidence: 99%

Calcium influx pathways in breast cancer: opportunities for pharmacological intervention

Azimi

Roberts‐Thomson

Monteith

2014

British J Pharmacology

131

114

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Ca2+ influx through Ca 2+ permeable ion channels is a key trigger and regulator of a diverse set of cellular events, such as neurotransmitter release and muscle contraction. Ca 2+ influx is also a regulator of processes relevant to cancer, including cellular proliferation and migration. This review focuses on calcium influx in breast cancer cells as well as the potential for pharmacological modulators of specific Ca 2+ influx channels to represent future agents for breast cancer therapy. Altered expression of specific calcium permeable ion channels is present in some breast cancers. In some cases, such changes can be related to breast cancer subtype and even prognosis. In vitro and in vivo models have now helped identify specific Ca 2+ channels that play important roles in the proliferation and invasiveness of breast cancer cells. However, some aspects of our understanding of Ca 2+ influx in breast cancer still require further study. These include identifying the mechanisms responsible for altered expression and the most effective therapeutic strategy to target breast cancer cells through specific Ca 2+ channels. The role of Ca 2+ influx in processes beyond breast cancer cell proliferation and migration should become the focus of studies in the next decade. [Ca 2+ ]CYT, cytoplasmic-free calcium; A-804598, N-cyano-N″-[(1S)-1-phenylethyl]-N'-5-quinolinyl-guanidine; EC, endothelial cells; EMT, epithelial to mesenchymal transition; ER + , oestrogen positive; ERα, oestrogen receptor α; ErbB2 (also known as HER2), human EGF receptor 2; IP3, inositol Abbreviations

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Section: Voltage-gated Calcium Permeable Ion Channelsmentioning

confidence: 99%