La Carcinine (β-alanyl-Histamine): Synthèse Rapide, Action Sur La Pression Sanguine Des Vertébrés

Abstract

1.-- Synthesis of carcinine was performed by direct condensation of beta-alanine with histamine (free base), in the presence of N-N'-dicyclocarbodiimide. The amine radical of beta-alanine was protected by the t-butoxycarbonyl radical. This fast and simple method yielded a perfectly pure crystalline product. 2.-- Carcinine had no influence upon heartbeat frequency nor on respiratory movements in rats. 3. -- Carcinine had a vasodepressive action upon Vertebrates. It was active at half the concentration of carnosine and at about a thousand times the concentration of histamine. It appeared that histamine lost a great extent of its activity when linked with beta-alanine.

Decomposition of carnosine and its methyl derivatives in aquatic animal meats during storage.

“…In the preliminary experiment, the big-eye tuna 16 days, and the change in the amount of anserine was determined. Although the meat turned putrid with the lapse of storage periods, there was no signi ficant change in the level of imidazole dipeptides (data not shown).…”