L1 Is Associated With Favorable Outcome in Neuroblastomas in Contrast to Adult Tumors

Wachowiak, Robin; Fiegel, Henning C.; Kaifi, Jussuf T.; Quaas, Alexander; Krickhahn, Annika; Schurr, Paulus; Erttmann, R.; Schachner, Melitta; Kluth, Dietrich; Sauter, Guido; Izbicki, Jakob R.

doi:10.1245/s10434-007-9608-0

Cited by 24 publications

(24 citation statements)

References 21 publications

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“…In correlation to existing clinical data of the children we observed that L1 expression was associated with favorable outcome [15]. Interestingly L1 (CD 171) is also a member of the immunoglobulin superfamily with similarities of the molecular structure [16].…”

Section: Discussionsupporting

confidence: 76%

Universal expression of cell adhesion molecule NCAM in neuroblastoma in contrast to L1: implications for different roles in tumor biology of neuroblastoma?

et al. 2008

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In contrast to L1, which was found to predict favorable outcome, NCAM is universally expressed in neuroblastoma. Therefore NCAM represents a marker for neuroblastomas irrespectively of their stages whereas L1 as an indicator for developing neuronal cells seems to identify more mature stages of this tumor. The high grade of NCAM expression might present a prerequisite for establishment of antibody-based therapies.

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Section: Discussionsupporting

confidence: 76%

Universal expression of cell adhesion molecule NCAM in neuroblastoma in contrast to L1: implications for different roles in tumor biology of neuroblastoma?

et al. 2008

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“…As reported for other adhesion molecules (for example L1CAM) [35,36], the biological function of ALCAM depends on the tumor type. This ambiguity is very clear in the oppositional effect of ALCAM in neuroendocrine tumors and adenocarcinoma of the pancreas.…”

Section: Discussionmentioning

confidence: 63%

ALCAM (CD166) Expression as Novel Prognostic Biomarker for Pancreatic Neuroendocrine Tumor Patients

Tachezy

Zander

Marx

et al. 2011

Journal of Surgical Research

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“…High L1CAM expression has been observed in various types of cancer and is associated with tumor invasion and unfavorable prognosis in carcinomas of the ovaries, endometrium, stomach, and breast (31). In contrast, expression of L1CAM correlates with favorable outcome in pediatric neuroblastoma, embryologically related to pheochromocytoma by its common derivation from the sympathoadrenal system (32). Immunohistochemical staining for L1CAM of 27 cases of adrenal and extra-adrenal pheochromocytoma and 140 human NETs of various origins showed high expression of the protein selectively in chromaffin cell-derived NETs.…”

Section: Discussionmentioning

confidence: 99%

Pheochromocytoma in rats with multiple endocrine neoplasia (MENX) shares gene expression patterns with human pheochromocytoma

Molatore

Liyanarachchi

Irmler³

et al. 2010

Proc. Natl. Acad. Sci. U.S.A.

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Pheochromocytomas are rare neoplasias of neural crest origin arising from chromaffin cells of the adrenal medulla and sympathetic ganglia (extra-adrenal pheochromocytoma). Pheochromocytoma that develop in rats homozygous for a loss-of-function mutation in p27Kip1 (MENX syndrome) show a clear progression from hyperplasia to tumor, offering the possibility to gain insight into tumor pathobiology. We compared the gene-expression signatures of both adrenomedullary hyperplasia and pheochromocytoma with normal rat adrenal medulla. Hyperplasia and tumor show very similar transcriptome profiles, indicating early determination of the tumorigenic signature. Overrepresentation of developmentally regulated neural genes was a feature of the rat lesions. Quantitative RT-PCR validated the up-regulation of 11 genes, including some involved in neural development: Cdkn2a, Cdkn2c, Neurod1, Gal, Bmp7, and Phox2a. Overexpression of these genes precedes histological changes in affected adrenal glands. Their presence at early stages of tumorigenesis indicates they are not acquired during progression and may be a result of the lack of functional p27Kip1. Adrenal and extra-adrenal pheochromocytoma development clearly follows diverged molecular pathways in MENX rats. To correlate these findings to human pheochromocytoma, we studied nine genes overexpressed in the rat lesions in 46 sporadic and familial human pheochromocytomas. The expression of GAL, DGKH, BMP7, PHOX2A, L1CAM, TCTE1, EBF3, SOX4, and HASH1 was up-regulated, although with different frequencies. Immunohistochemical staining detected high L1CAM expression selectively in 27 human pheochromocytomas but not in 140 nonchromaffin neuroendocrine tumors. These studies reveal clues to the molecular pathways involved in rat and human pheochromocytoma and identify previously unexplored biomarkers for clinical use. Cdkn1b | rat model | transcriptome analysis | progenitor signature

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L1 Is Associated With Favorable Outcome in Neuroblastomas in Contrast to Adult Tumors

Cited by 24 publications

References 21 publications

Universal expression of cell adhesion molecule NCAM in neuroblastoma in contrast to L1: implications for different roles in tumor biology of neuroblastoma?

Universal expression of cell adhesion molecule NCAM in neuroblastoma in contrast to L1: implications for different roles in tumor biology of neuroblastoma?

ALCAM (CD166) Expression as Novel Prognostic Biomarker for Pancreatic Neuroendocrine Tumor Patients

Pheochromocytoma in rats with multiple endocrine neoplasia (MENX) shares gene expression patterns with human pheochromocytoma

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