L0028 Intermittent hypoxia and sleep restriction: motor, cognition and neurochemical alterations in rats

Perry, Juliana C.; D’Almeida, Vânia; Lima, Maria Adriely Cunha; Godoi, Francisco R.L.; Vital, Maria A.B.F.; Oliveira, Maria G.; Tufik, Sérgio

doi:10.1016/s1389-9457(07)70396-9

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“…However, sleep apnea is characterised by a collapse of upper airway breathing associated to sleep fragmentation. Recently, our group developed a rodent model that evaluated the effects of CIH associated with sleep restriction and provided important new insights in this field (Perry et al, 2007(Perry et al, , 2008. Thus, we attempt to determine the effects of CIH associated with sleep restriction on heart rate, blood pressure, sympathetic nerve activity and its consequences in the plasma renin-angiotensin system (RAS) in rats.…”

Section: Introductionmentioning

confidence: 99%

Differential sympathetic activation induced by intermittent hypoxia and sleep loss in rats: Action of angiotensin (1–7)

Perry

Bergamaschi

Campos

et al. 2011

Autonomic Neuroscience

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The present study attempted to evaluate the effects of chronic intermittent hypoxia (CIH) associated with sleep restriction in hemodynamic parameters and the plasma renin-angiotensin system. Wistar-Hannover rats were submitted to isolated CIH exposure (1000-1600 h), sleep restriction (1600-1000 h), defined as 18-h paradoxical sleep deprivation followed by 6-h sleep permission period and CIH associated to sleep restriction for 21 days. The CIH and sleep restriction group showed a preferential increase in renal sympathetic nervous system (rSNA) associated with a reduction in plasma angiotensin (1-7) concentrations. However, CIH-sleep restriction rats did not modify rSNA and showed a higher angiotensin (1-7) concentration when compared to isolated CIH and sleep restriction. These results suggest that CIH and sleep restriction impaired the cardiovascular system, and its association to sleep loss can modify these effects by partially restoring circulating angiotensin (1-7).

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Section: Introductionmentioning

confidence: 99%