L-tyrosine polymerization-based ultrasensitive multi-analyte enzymatic biosensor

Liu, Lanjunzi; Kang, Xiuzhi; Chen, Chao; Zhang, Heping; Chen, Chenpu; Xie, Qingji

doi:10.1016/j.talanta.2017.12.014

Cited by 10 publications

(9 citation statements)

References 47 publications

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“…The FT-IR spectra of Tyr, PTyr-tyrosinase, and PTyr-tyrosinase-GOx composites showed significant NH stretching vibrations (3490–3300 cm –1 ) of secondary amines, indicating the polymerization and newly formed benzoquinone CO bands also observed from 950 to 650 cm –1 . The scanning electron microscopy images of PTyr-modified electrodes through enzymatic oxidation showed a comparatively uniform electrode distribution as compared to electrodes fabricated through chemical oxidation . Similarly, an immunosensor was developed by the adsorption of PTyr of molecular weight 10–40 kDa on MWCNTs through electrochemical oxidation.…”

Section: Synthesis Strategies Of Tyrosine-derived Polymersmentioning

confidence: 98%

“…The scanning electron microscopy images of PTyrmodified electrodes through enzymatic oxidation showed a comparatively uniform electrode distribution as compared to electrodes fabricated through chemical oxidation. 121 Similarly, an immunosensor was developed by the adsorption of PTyr of molecular weight 10−40 kDa on MWCNTs through electrochemical oxidation. Prostate-specific antigen (PSA) peptide was conjugated using an EDC cross-linker, thereby enhancing the electrochemical signal of the electrode.…”

Section: Synthesis Of α-Aminomentioning

confidence: 99%

“…Also, it exhibited an excellent anti-interference ability in the presence of common interferences. 121 Egui ́laz et al reported GCE/SWCNT-PTyr electrodes and fabricated a nicotinamide adenine dinucleotide (NADH) and ethanol biosensor by immobilizing alcohol dehydrogenase (ADH) through Nafion (Naf) entrapment onto GCE/ SWCNT-PTyr. The SWCNT-PTyr dispersions were cast onto the GCE to develop GCE/SWCNT-PTyr to detect the NADH.…”

Section: Biosensorsmentioning

confidence: 99%

“…(ii) Illustration of PTyr-tyrosinase-GOx/Au electrode fabrication and its application toward the detection of phenolic/glucose and inhibitive detection of Cr(III)/Cr(VI). Reprinted with permission from ref . Copyright 2018 Elsevier.…”

Section: Biomedical Applications Of Tyrosine-derived Polymersmentioning

confidence: 99%

“…The PTyr-tyrosinase-GOx/Au electrode displayed higher sensitivity and lower LOD for glucose (0.22 μM) and Cr(VI) (5 × 10 –3 μM). Also, it exhibited an excellent anti-interference ability in the presence of common interferences …”

Section: Biomedical Applications Of Tyrosine-derived Polymersmentioning

confidence: 99%

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Tyrosine-Derived Polymers as Potential Biomaterials: Synthesis Strategies, Properties, and Applications

et al. 2023

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Peptide-based polymers are evolving as promising materials for various biomedical applications. Among peptidebased polymers, polytyrosine (PTyr)-based and L-tyrosine (Tyr)derived polymers are unique, due to their excellent biocompatibility, degradability, and functional as well as engineering properties. To date, different polymerization techniques (ringopening polymerization, enzymatic polymerization, condensation polymerization, solution-interfacial polymerization, and electropolymerization) have been used to synthesize various PTyr-based and Tyr-derived polymers. Even though the synthesis starts from Tyr, different synthesis routes yield different polymers (polypeptides, polyarylates, polyurethanes, polycarbonates, polyiminocarbonate, and polyphosphates) with unique functional characteristics, and these polymers have been successfully used for various biomedical applications in the past decades. This Review comprehensively describes the synthesis approaches, classification, and properties of various PTyr-based and Tyr-derived polymers employed in drug delivery, tissue engineering, and biosensing applications.

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Section: Synthesis Strategies Of Tyrosine-derived Polymersmentioning

confidence: 98%

Section: Synthesis Of α-Aminomentioning

confidence: 99%

Section: Biosensorsmentioning

confidence: 99%

Section: Biomedical Applications Of Tyrosine-derived Polymersmentioning

confidence: 99%

Section: Biomedical Applications Of Tyrosine-derived Polymersmentioning

confidence: 99%

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Tyrosine-Derived Polymers as Potential Biomaterials: Synthesis Strategies, Properties, and Applications

et al. 2023

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Discriminative detection of glucose and urea with a composite polymer nanofiber based matrix

Apetrei,

Guven,

Camurlu

2024

ChemistrySelect

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Detection and quantification of glucose and urea are fundamental in medical analysis, real‐time monitoring, and point of care analysis. However, such analyses generally require sophisticated instrumentation and specialized personnel. Furthermore, discriminative detection of multiple analytes is often necessary for treatment and diagnosis. To address this challenge, this study describes a proof‐of‐concept for discriminative sensitive amperometric detection of both analytes. This was achieved by the fabrication of a polymer‐MWCNTs composite nanofiber matrix upon which glucose oxidase (GOD) and urease were co‐immobilized to allow detection of the corresponding substrates (glucose and urea). The (PAN(−MWCNTs)/Urease‐GOD) biosensor showed good performance in: (i) glucose biosensing with sensitivity of 31±5 μAmM−2cm−2 within an extended linear range (0.1–5.0 mM) and a limit of detection of 3.7 μM, and (ii) urea detection at very low concentration (4–30 and 30–90 μM) with sensitivity up to 350±19 μAmM−2cm−2 and very low LOD (0.1 μM). The analogous mono‐enzyme platform for urea detection (PAN(−MWCNTs)/Urease) showed very similar performance as the bi‐enzyme sensor, suggesting little to no influence of co‐immobilization on Urease activity, thus confirming that the two catalytic processes are independent of each other. The biosensors exhibited high accuracy in the detection of both analytes (at normal and pathological levels) in human serum, thus proving that the biosensor described herein can have practical applications in healthcare and remote patient monitoring.

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Nanobiosensors for Detection of Phenolic Compounds

Achi

Bensana

Bouguettoucha

et al. 2020

Nanotechnology in the Life Sciences

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L-tyrosine polymerization-based ultrasensitive multi-analyte enzymatic biosensor

Cited by 10 publications

References 47 publications

Tyrosine-Derived Polymers as Potential Biomaterials: Synthesis Strategies, Properties, and Applications

Tyrosine-Derived Polymers as Potential Biomaterials: Synthesis Strategies, Properties, and Applications

Discriminative detection of glucose and urea with a composite polymer nanofiber based matrix

Nanobiosensors for Detection of Phenolic Compounds

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