l-Thyroxine does not prevent immunemediated sensorineural hearing loss in autoimmune thyroid diseases

Rodríguez-Valiente, Antonio; Álvarez-Montero, Óscar; Górriz-Gil, Carmen; García-Berrocal, José Ramón

doi:10.1016/j.otorri.2018.06.001

Cited by 6 publications

(3 citation statements)

References 13 publications

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“…Meanwhile, A prospective observational study conducted by Almagor et al (28) in Israel indicated a high prevalence of hearing impairment among patients with congenital hypothyroidism, predominantly of the conductive type. Unlike the above study, however, more observed that sensorineural hearing loss was most common in congenital hypothyroidism, higher frequencies in particular (29)(30)(31)(32), and this phenomenon was not associated with THS and free T4 levels (33)(34)(35). There was also a contradictory conclusion, François et al (36) found no signi cant difference for the auditory thresholds at high frequencies between congenital hypothyroidism treated with L-thyroxine and control group, regardless of the cause of the thyroid failure or hormone level and the age at the start of treatment.…”

Section: Discussioncontrasting

confidence: 68%

Causal relationship between hypothyroidism and the risk of hearing loss: A bidirectional two-sample Mendelian randomization study

Zhu

Liu

2023

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Background Hypothyroidism's causal direction and the magnitude of its association with hearing loss is uncertain due to the limitations of observational studies. This study aims to investigate the relationship between hypothyroidism and hearing loss using bidirectional two-sample mendelian randomization (MR).Materials and Methods The genetic variants of 462,933 participants in the hypothyroidism study and 323,978 participants in the hearing loss study were used for bidirectional two-sample MR. Independent genetic variants that were significantly (P < 5×10− 8) associated with each exposure were considered as instruments. To test for sensitivity, Cochran's Q test, the MR-Egger intercept test, and leave-one-out analysis were applied apart from the multiplicative random effects-inverse variance weighted (MRE-IVW) approach used as the main MR analysis.Results The forward MR revealed a significant causal estimate for the genetically predicted hypothyroidism with the high risk of hearing loss [MRE-IVW: odds ratio (OR) = 1.092, P = 0.003]. However, the reverse MR analysis found no significant correlation between genetically predicted hearing loss and hypothyroidism (MRE-IVW: OR = 1.04, P = 0.113). Sensitivity analyses showed that the causal association estimations were stable and reliable.Conclusion In this MR study, we demonstrated hypothyroidism was causally associated with a high risk of hearing loss. However, there was no evidence to support the causality of hearing loss on hypothyroidism.

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Section: Discussioncontrasting

confidence: 68%

Causal relationship between hypothyroidism and the risk of hearing loss: A bidirectional two-sample Mendelian randomization study

Zhu

Liu

2023

Preprint

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“…Часто при АИТ у пациентов также наблюдается потеря слуха, которую связывают с вторичным иммуноопосредованным заболеванием внутреннего уха. Внутреннее ухо имеет схожие клеточные рецепторы с щитовидной железой, поэтому аутоантитела, продуцируемые организмом при АИТ, могут поражать и слух [13].…”

Section: аутоиммунные заболевания щитовидной железыunclassified

The role of regulatory T cells in autoimmune thyroiditis

et al. 2021

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Autoimmune thyroiditis is an organ-specific autoimmune disease caused by the activation of self-reactive CD4+ T cells. Regulatory T (Treg) cells are a population of T cells that play a central role in immunological tolerance by suppressing selfreactive cells. CD4+ Tregs are divided into thymic (tTreg) and peripheral (pTreg). tTregs perform their functions through cytokine-independent mechanisms, pTregs – through IL-10, TGF-β and IL-35. Tregs perform a protective function against AIT. Studies of Treg level in AIT show different results, in most cases Treg level is increased, and their function is impaired. Treg function in AIT is affected by many factors, such as the level of thyroglobulin, vitamin D etc. Apart from the Treg level itself, the Th17/Treg ratio is also crucial in AIT. Activation of Tregs and modification of the Th17/Treg ratio can be used in AIT treatment.

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“…In our study [ 5 ], we noted that Hashimoto’s thyroiditis was very commonly associated with patients suffering from AIHL; 13 (24.5%) out of 53 patients with AIHL had concomitant Hashimoto’s thyroiditis. It has been shown that, in Hashimoto’s thyroiditis, the number of T-regulatory (Treg) cells are reduced, and their function is defective, resulting in their limited downregulating effect against the ongoing autoimmune process and leading to extensive defects in the inner ear [ 16 ]. Close monitoring of hearing is recommended in the treatment of these patients with Hashimoto’s thyroiditis using a thorough audiometric test battery at least once a year.…”

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confidence: 99%