L’hémolyse : une cause d’erreur dans l’interprétation de l’hémoglobine glycosylée

Debard, Anne-Lise; Charmion, S.; Ameur, S. Ben; Gaultier, J.-B.; Cathébras, P.

doi:10.1016/j.revmed.2008.10.010

Cited by 8 publications

(3 citation statements)

References 6 publications

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“…Similar to prior reports of RDW predicting CVD events independent of inflammation (hsCRP) [12] and renal function [12], we found RDW to predict higher HbA1c levels independent of these factors. We found that the association between RDW and HbA1c existed independent of covariates like BT, treatment of anemia, deficiency of iron, and serum levels of LDH and total bilirubin, all of which can indicate a spurious increase in HbA1c levels and can also indicate anisocytosis [4,5]. Furthermore, RDW predicted HbA1c independent of cancer and thyroid and liver disease, which can additionally affect RDW values [13,14].…”

Section: Discussionmentioning

confidence: 99%

“…Large population-based studies have noted that HbA1c is associated with incident type 2 diabetes mellitus (DM) and cardiovascular disease (CVD) and all cause mortality in patients without a prior history of DM [1,2,3]. HbA1c levels increase with age, chronic subclinical inflammation, and possibly oxidative stress, and also in conditions that can adversely affect red blood cell survival, for example hemolytic anemia, blood transfusion (BT), chronic malaria, or major blood loss [1,4,5]. Recently, elevated red cell distribution width (RDW), a measure of anisocytosis, has gained importance as a marker of adverse cardiovascular outcomes and all cause mortality [6,7,8].…”

Section: Introductionmentioning

confidence: 99%

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The Association of Red Cell Distribution Width with Glycated Hemoglobin among Healthy Adults without Diabetes Mellitus

Veeranna¹,

Zalawadiya²,

Panaich³

et al. 2012

Cardiology

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Background: Red cell distribution width (RDW) and hemoglobin A1c (HbA1c) are both known to be predictive of future cardiovascular disease (CVD). Objective: We hypothesized that RDW would be associated with HbA1c in adults without diabetes independent of fasting blood glucose (FBG). Methods: This cross-sectional study included 15,343 nondiabetic adults, free of CVD, enrolled in NHANES 1999–2008. Adjusted means of RDW were calculated across HbA1c categories for the overall population. Multivariable regression analyses were performed analyzing the association between RDW and HbA1c for individuals with available data on FBG (n = 7,454). Results: RDW significantly correlated with HbA1c (r = 0.27, p < 0.001; n = 15,343), with a gradual increase in adjusted mean RDW across HbA1c categories (12.59% ± 0.02% in the group with HbA1c ≤4.8% vs. 12.92% ± 0.02% in the group with HbA1c >5.8%, p < 0.001 for trend). In regression analyses, RDW independently predicted HbA1c (β-coefficient 0.034, 95% CI 0.026–0.042, p < 0.001). Conclusion: RDW significantly predicts HbA1c independent of FBG in healthy nondiabetic adults, suggesting the possibility of chronic hyperglycemia mediating the association between RDW and CVD.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Association of Red Cell Distribution Width with Glycated Hemoglobin among Healthy Adults without Diabetes Mellitus

Veeranna¹,

Zalawadiya²,

Panaich³

et al. 2012

Cardiology

View full text Add to dashboard Cite

show abstract

“…As a rule, the patient’s erythrocytes are a mixture of transfused red cells from donors with a normal Hb composition, with Hb A of around 95%, and Hb F of 2–3%. Storage erythrocytes have functional and metabolic differences as well as a considerably shorter life span compared to healthy red cells 3,4,74,87–89. On the other hand, the results of a recent study showed that assessment of HbA1c prior to transfusion is a reliable index of the average glucose concentration for the period between transfusions ranging from 2–4 weeks and up to 40 days.…”

Section: Clinical Characteristics and Management Of Igt And Dm In Thamentioning

confidence: 99%

The Icet-a Recommendations for the Diagnosis and Management of Disturbances of Glucose Homeostasis in Thalassemia Major Patients

Sanctis¹

2016

Mediterr J Hematol Infect Dis

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Iron overload in patients with thalassemia major (TM) affects glucose regulation and is mediated by several mechanisms. The pathogenesis of glycaemic abnormalities in TM is complex and multifactorial. It has been predominantly attributed to a combination of reduced insulin secretory capacity and insulin resistance. The exact mechanisms responsible for progression from norm glycaemia to overt diabetes in these patients are still poorly understood but are attributed mainly to insulin deficiency resulting from the toxic effects of iron deposited in the pancreas and insulin resistance. A group of endocrinologists, haematologists and paediatricians, members of the International Network of Clinicians for Endocrinopathies in Thalassemia and Adolescence Medicine (ICET-A) convened to formulate recommendations for the diagnosis and management of abnormalities of glucose homeostasis in thalassemia major patients on the basis of available evidence from clinical and laboratory data and consensus practice. The results of their work and discussions are described in this article.

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Defining trimester-specific reference intervals for carbohydrate deficient transferrin in pregnant women

Göttgens,

Haverkate,

Langelaan

et al. 2024

Clinica Chimica Acta

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L’hémolyse : une cause d’erreur dans l’interprétation de l’hémoglobine glycosylée

Cited by 8 publications

References 6 publications

The Association of Red Cell Distribution Width with Glycated Hemoglobin among Healthy Adults without Diabetes Mellitus

The Association of Red Cell Distribution Width with Glycated Hemoglobin among Healthy Adults without Diabetes Mellitus

The Icet-a Recommendations for the Diagnosis and Management of Disturbances of Glucose Homeostasis in Thalassemia Major Patients

Defining trimester-specific reference intervals for carbohydrate deficient transferrin in pregnant women

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