L’haptoglobine chez les enfants atteints de paludisme grave a <i>Plasmodium falciparum</i> de 0 à 15 ans : Relations avec l’âge, la parasitémie et le taux d’hémoglobine

Abstract

L'haptoglobine chez les enfants atteints de paludisme grave a Plasmodium falciparum : Relations avec l'âge, la parasitemie et le taux d'hémoglobine. 6426 ABSTRACT :Haptoglobin in children with severe falciparum malaria, aged from 0 to 15 years old: Relationships according to age, parasitemia and hemoglobin rate.Objectives: This study was assaying haptoglobin in children aged 0-15 years with severe Plasmodium falciparum malaria and the relationship between this protein of inflammation according to age, parasitemia and hemoglobin rate. Methodology and results: It was a prospective study in 70 children with severe Plasmodium falciparum malaria aged between 0 and 15 years recruited in the services of Pediatric Hospitals and University (CHU) of Cocody and Yopougon (Abidjan). COBAS INTEGRA 400 turbidimetric test was used for the measurement of Haptoglobin in human serum. Anti-Haptoglobin antibodies when mixed with samples containing Haptoglobin, formed insoluble complexes. These complexes caused an absorbance change, dependent upon the Haptoglobin concentration of the patient sample that could be quantified by comparison from a calibrator of know Haptoglobin concentration. The results showed that during severe falciparum malaria, most of children (69.44 to 88.2%) had hypohaptoglobinemia. The average rate of Haptoglobin was lower in children 0-5 years, reflecting a higher hemolysis. The average rate of this protein was proportional to age and mean hemoglobin, but inversely proportional to the mean parasite. Conclusion and application of results: This study showed that in children with severe Plasmodium falciparum malaria, there was relationship between Haptoglobin levels and age, parasitemia and hemoglobin rate. In developing countries where malaria anemia causes death of many children every year, Haptoglobin could be an excellent marker for medical aftercare of inflammatory diseases and intravascular hemolysis remission in pediatric practice.

Exploring the heterogeneity of human exposure to malaria vectors in an urban setting, Bouaké, Côte d’Ivoire, using an immuno-epidemiological biomarker

“…In Côte d’Ivoire, malaria transmission is stable throughout the country and presents peaks during the rainy season [ 22 ]. This study was conducted in three neighbourhoods of Bouaké: Kennedy (KEN), N’gattakro (NGA) and Dar-es-Salam (DAR).…”